About   Help   FAQ
Ighg2b Gene Detail
Summary
  • Symbol
    Ighg2b
  • Name
    immunoglobulin heavy constant gamma 2B
  • Synonyms
    gamma2b, IgG2b
Location &
Maps
more
  • Sequence Map
    Chr12:113267934-113271553 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.10 cM, cytoband C1-qter
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    23
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96445
 gene segment Chr12:113266585-113271553 (-)
129S1/SvImJ ENSMUSG00200027749
 gene segment Chr12:105048276-105053241 (-)
A/J ENSMUSG00195046203
 gene segment Chr12:107549726-107554696 (-)
AKR/J ENSMUSG00220037757
 gene segment Chr12:105479568-105484538 (-)
BALB/cJ ENSMUSG00180047738
 protein coding gene Chr12:106818213-106821827 (-)
BALB/cJ ENSMUSG00180051550
 gene segment Chr12:106816864-106821829 (-)
C3H/HeJ ENSMUSG00175043670
 gene segment Chr12:109401077-109406042 (-)
C3H/HeJ ENSMUSG00175033284
 protein coding gene Chr12:109402426-109406040 (-)
C57BL/6NJ ENSMUSG00215049766
 gene segment Chr12:106087589-106092557 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0000005
 gene segment Chr12:107755726-107757377 (-)
CAST/EiJ ENSTCUG00005042246
 gene segment Chr12:105719062-105724143 (-)
CBA/J ENSMUSG00210037992
 gene segment Chr12:106457521-106462486 (-)
CBA/J ENSMUSG00210030241
 protein coding gene Chr12:106458870-106462484 (-)
DBA/2J ENSMUSG00185025833
 protein coding gene Chr12:108275562-108279176 (-)
DBA/2J ENSMUSG00185031515
 gene segment Chr12:108274213-108279178 (-)
FVB/NJ ENSMUSG00205041305
 gene segment Chr12:105487184-105492154 (-)
JF1/MsJ ENSUMUG00000033527
 gene segment Chr12:113064065-113069033 (-)
LP/J ENSMUSG00230045105
 gene segment Chr12:115315617-115320585 (-)
NOD/ShiLtJ ENSMUSG00190028692
 gene segment Chr12:104898677-104903645 (-)
NZO/HlLtJ ENSMUSG00225041831
 protein coding gene Chr12:117059424-117063039 (-)
PWK/PhJ ENSLUMG00010048523
 gene segment Chr12:106522001-106527093 (-)
SPRET/EiJ ENSMSPG00010019546
 gene segment Chr12:108768127-108773102 (-)
WSB/EiJ ENSIUOG00005036510
 protein coding gene Chr12:105770905-105774525 (-)



Homology
more
  • Human Ortholog
    IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
  • Links
    NCBI Gene ID: 3500
    UniProt: P01857

  • Chr Location
    14q32.33; chr14:105736343-105743071 (-)  GRCh38
  • Human Ortholog
    IGHG2, immunoglobulin heavy constant gamma 2 (G2m marker)
  • Links
    NCBI Gene ID: 3501
    UniProt: P01859

  • Chr Location
    14q32.33; chr14:105639559-105644790 (-)  GRCh38
  • Human Ortholog
    IGHG3, immunoglobulin heavy constant gamma 3 (G3m marker)
  • Synonyms
    IgG3
  • Links
    NCBI Gene ID: 3502
    UniProt: P01860

  • Chr Location
    14q32.33; chr14:105764503-105771405 (-)  GRCh38
  • Human Ortholog
    IGHG4, immunoglobulin heavy constant gamma 4 (G4m marker)
  • Links
    NCBI Gene ID: 3503
    UniProt: P01861

  • Chr Location
    14q32.33; chr14:105620506-105626066 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    4
  • Endonuclease-mediated
    1
  • Spontaneous
    2
  • Transgenic
    1
  • Genomic Mutations
    1 involving Ighg2b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
  • All Sequences
    36
  • RefSeq
    1
  • UniProt
    3
Representative SequencesLengthStrain/SpeciesFlank
genomic 16016 NCBI Gene Model | MGI Sequence Detail 3620 C57BL/6J ±  kb
polypeptide P01867 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009184 immunoglobulin heavy constant gamma 2B
    (term hierarchy)
  • InterPro Domains
    IPR050380 Immune Recognition and Response Modulators
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
  • GlyGen
    P01867 4 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 52
    Genomic 36
    cDNA 12
    Other 4
Other
Accession IDs
less
MGD-MRK-11242
References
more
  • Summaries
    All 83
    Developmental Gene Expression 1
    Gene Ontology 23
    Phenotypes 7
  • Earliest
    J:12170 Herzenberg LA, et al., Genetics of antibodies. Annu Rev Genet. 1968;2:209-44
  • Latest
    J:377763 Brown JA, et al., Gut microbiota promotes immune tolerance at the maternal-fetal interface. Cell. 2026 Jan 8;189(1):196-214.e24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory