About   Help   FAQ
Igh Complex/Cluster/Region Detail
Summary
  • Symbol
    Igh
  • Name
    immunoglobulin heavy chain complex
Location &
Maps
more
  • Sequence Map
    Chr12:113258768-116009954 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43670 from dbSNP Build 142
  • PCR
  • RFLP
Human Diseases
more
  • Diseases
    1 with Igh mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    107 phenotypes from 66 alleles in 40 genetic backgrounds
    95 phenotypes from multigenic genotypes
    380 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal B cell morphology and physiology.
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic 111507 NCBI Gene Model | MGI Sequence Detail 2751187 C57BL/6J ±  kb
For the selected sequence
Molecular
Reagents
less
  • All nucleic 11
    Genomic 2
    cDNA 2
    Primer pair 6
    Other 1
Other
Accession IDs
less
MGD-MRK-11239
References
more
  • Summaries
    All 511
    Diseases 6
    Phenotypes 380
  • Earliest
    J:5559 Taylor BA, et al., Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21;256(5519):644-6
  • Latest
    J:271592 Litzler LC, et al., PRMT5 is essential for B cell development and germinal center dynamics. Nat Commun. 2019 Jan 3;10(1):22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/16/2019
MGI 6.13
The Jackson Laboratory