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Igh Complex/Cluster/Region Detail
Summary
  • Symbol
    Igh
  • Name
    immunoglobulin heavy chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96442
    NCBI Gene: 111507
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • PCR
  • RFLP
Human Diseases
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  • Diseases
    1 with Igh mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    107 phenotypes from 66 alleles in 40 genetic backgrounds
    102 phenotypes from multigenic genotypes
    415 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal B cell morphology and physiology.
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Molecular
Reagents
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  • All nucleic 11
    Genomic 2
    cDNA 2
    Primer pair 6
    Other 1
Other
Accession IDs
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MGD-MRK-11239
References
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  • Summaries
    All 547
    Diseases 6
    Phenotypes 415
  • Earliest
    J:284952 Bosma MJ, et al., Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice. J Exp Med.. 1974;139(3):512-27
  • Latest
    J:284593 Skokos D, et al., A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies. Sci Transl Med. 2020 Jan 8;12(525)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory