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Igh Complex/Cluster/Region Detail
Summary
  • Symbol
    Igh
  • Name
    immunoglobulin heavy chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96442
    NCBI Gene: 111507
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    25 experiments
Human Diseases
more
  • Diseases
    1 with Igh mouse models

Human Disease Mouse Models
       Leukemia, Chronic Lymphocytic; CLL   OMIM: 151400 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    107 phenotypes from 66 alleles in 40 genetic backgrounds
    95 phenotypes from multigenic genotypes
    322 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    119
  • Targeted
    89
  • Transgenic
    30
  • Genomic Mutations
    11 involving Igh
Mice homozygous for a knock-out allele exhibit abnormal B cell morphology and physiology.
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Polymorphisms
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  • PCR
  • RFLP
Molecular
Reagents
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  • All nucleic 11
    Genomic 2
    cDNA 2
    Primer pair 6
    Other 1
Other
Accession IDs
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MGD-MRK-11239
References
more
  • Summaries
    All 342
    Diseases 7
    Phenotypes 322
  • Earliest
    J:5559 Taylor BA, et al., Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21;256(5519):644-6
  • Latest
    J:233319 Domeier PP, et al., IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med. 2016 May 2;213(5):715-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory