Rr91 Other Genome Feature Detail

Summary

• Symbol
  Rr91
• Name
  regulatory region 91
• Synonyms
  hs5, hs6, hs7

• Feature Type
  CTCF binding site
• IDs
  MGI:6833878
• Regulates expression of
  Igh (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr12:113185086-113188506 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• shortest span between but excluding primers: chr12:113185086-113188506

• Genetic Map
  Chromosome 12, Syntenic

Strain
Comparison

• SNPs within 2kb
  200 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:181838 Volpi SA, et al., Germline Deletion of Igh 3' Regulatory Region Elements hs 5, 6, 7 (hs5-7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus. J Immunol. 2012 Mar 15;188(6):2556-66
• Latest
  J:359652 Bruzeau C, et al., Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination. Nucleic Acids Res. 2024 Nov 11;52(20):12281-12294

Rr91 regulates expression of:

Feature	Feature Type	Location	Reference
Igh, immunoglobulin heavy chain complex	complex/cluster/region	Chr12:113222388-115973574 (-)	J:181838