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Igfbp5 Gene Detail
Summary
  • Symbol
    Igfbp5
  • Name
    insulin-like growth factor binding protein 5
  • Synonyms
    IGFBP-5, IGFBP-5P
  • Feature Type
    protein coding gene
  • IDs
    MGI:96440
    NCBI Gene: 16011
  • Gene Overview
    MyGene.info: IGFBP5
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72858065-72874865 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96440
protein coding gene Chr1:72857932-72874884 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016137
protein coding gene Chr1:73398451-73416969 (-)
A/J MGP_AJ_G0016120
protein coding gene Chr1:70810044-70828159 (-)
AKR/J MGP_AKRJ_G0016077
protein coding gene Chr1:72808490-72825465 (-)
BALB/cJ MGP_BALBcJ_G0016075
protein coding gene Chr1:70892890-70909875 (-)
C3H/HeJ MGP_C3HHeJ_G0015906
protein coding gene Chr1:73117885-73136568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016528
protein coding gene Chr1:76239470-76256429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014249
protein coding gene Chr1:66467912-66484532 (-)
CAST/EiJ MGP_CASTEiJ_G0015490
protein coding gene Chr1:72410569-72427542 (-)
CBA/J MGP_CBAJ_G0015879
protein coding gene Chr1:78739377-78759799 (-)
DBA/2J MGP_DBA2J_G0015980
protein coding gene Chr1:70157363-70174728 (-)
FVB/NJ MGP_FVBNJ_G0015983
protein coding gene Chr1:69343075-69360009 (-)
LP/J MGP_LPJ_G0016052
protein coding gene Chr1:74457328-74474263 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016003
protein coding gene Chr1:82175716-82194646 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016575
protein coding gene Chr1:72831152-72848102 (-)
PWK/PhJ MGP_PWKPhJ_G0015277
protein coding gene Chr1:69609969-69627061 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015055
protein coding gene Chr1:72188047-72204946 (-)
WSB/EiJ MGP_WSBEiJ_G0015552
protein coding gene Chr1:72659127-72676094 (-)



Homology
more
  • Human Ortholog
    IGFBP5, insulin like growth factor binding protein 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGFBP5, insulin like growth factor binding protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IBP5
  • Links
    NCBI Gene ID: 3488
    neXtProt AC: NX_P24593
    UniProt: P24593

  • Chr Location
    2q35; chr2:216672105-216695549 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    12 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Igfbp5
  • Find Mice (IMSR)
Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16011 NCBI Gene Model | MGI Sequence Detail 16801 C57BL/6J ±  kb
transcript NM_010518 RefSeq | MGI Sequence Detail 5854 FVB/N  
polypeptide Q07079 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008951 insulin-like growth factor-binding protein 5
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR009168 Insulin-like growth factor binding protein
    IPR012213 Insulin-like growth factor binding protein 5
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
    IPR036857 Thyroglobulin type-1 superfamily
Molecular
Reagents
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  • All nucleic 943
    Genomic 4
    cDNA 934
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11237, MGI:2138187, MGI:2138571
References
more
  • Summaries
    All 133
    Developmental Gene Expression 66
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:270164 Guo M, et al., Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun. 2019 Jan 3;10(1):37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory