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Igfbp5
Gene Detail
Symbol

Name
ID
Igfbp5
insulin-like growth factor binding protein 5
MGI:96440
Synonyms
IGFBP-5, IGFBP-5P
Feature Type
protein coding gene
Genetic Map
Chromosome 1
36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:72857932-72874884 bp, - strand
From VEGA annotation of GRCm38

  16953 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp5

Human
homologs
Human Homolog IGFBP5, insulin-like growth factor binding protein 5
NCBI Gene ID 3488
neXtProt AC  NX_P24593
Human Synonyms  IBP5
Human Chr (Location)  2q35; chr2:216672105-216695549 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls.
 
Interactions
Igfbp5 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to cAMP, cellular response to organic cyclic compound, ...
Component extracellular region, extracellular space, ...
Function fibronectin binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (238)    Tissues (144)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 199
Northern blot 19
RT-PCR 20
cDNA source data(928)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(941) Genomic(4) cDNA(932) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017306 (Evidence)
Ensembl Gene ModelENSMUSG00000026185 (Evidence)
Entrez Gene16011 (Evidence)
UniGene405761
DFCITC1572247, TC1602155, TC1613706, TC1649942, TC1712962
DoTSDT.101397514, DT.101720902, DT.101720903, DT.94128092, DT.94128140, DT.94388924
Consensus CDS ProjectCCDS15037.1
International Mouse Knockout Project StatusIgfbp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017306 VEGA Gene Model | MGI Sequence Detail 16953 C57BL/6J ±  kb
transcript OTTMUST00000042008 VEGA | MGI Sequence Detail 6006 Not Applicable 
polypeptide OTTMUSP00000018888 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR012213 Insulin-like growth factor binding protein 5
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008951 insulin-like growth factor-binding protein 5
References
(Earliest) J:12803 Schuller AG, et al., Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
(Latest) J:205284 Storer M, et al., Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell. 2013 Nov 21;155(5):1119-30
All references(107)
Other
accession IDs
MGD-MRK-11237, MGI:2138187, MGI:2138571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory