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Igfbp5 Gene Detail
Summary
  • Symbol
    Igfbp5
  • Name
    insulin-like growth factor binding protein 5
  • Synonyms
    IGFBP-5, IGFBP-5P
  • Feature Type
    protein coding gene
  • IDs
    MGI:96440
    NCBI Gene: 16011
  • Gene Overview
    MyGene.info: IGFBP5
Location & Maps
more
  • Sequence Map
    Chr1:72857932-72874884 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16953 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    IGFBP5, insulin like growth factor binding protein 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IGFBP5, insulin like growth factor binding protein 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IBP5
  • Links
    NCBI Gene ID: 3488
    neXtProt AC: NX_P24593

  • Chr Location
    2q35; chr2:216672105-216695549 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    12 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Igfbp5
Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017306 VEGA Gene Model | MGI Sequence Detail 16953 C57BL/6J ±  kb
transcript OTTMUST00000042008 VEGA | MGI Sequence Detail 6006 Not Applicable  
polypeptide OTTMUSP00000018888 VEGA | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008951 insulin-like growth factor-binding protein 5
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR009168 Insulin-like growth factor binding protein
    IPR012213 Insulin-like growth factor binding protein 5
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
Molecular
Reagents
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  • All nucleic 941
    Genomic 4
    cDNA 932
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11237, MGI:2138187, MGI:2138571
References
more
  • Summaries
    All 107
    Developmental Gene Expression 56
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:12803 Schuller AG, et al., Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
  • Latest
    J:231945 Dina C, et al., Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct;47(10):1206-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory