Igfbp5
Gene Detail

Symbol Name ID

Igfbp5 insulin-like growth factor binding protein 5 MGI:96440

Synonyms

IGFBP-5, IGFBP-5P

Feature Type

protein coding gene

Genetic Map

Chromosome 1

36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr1:72857932-72874884 bp, - strand From VEGA annotation of GRCm38   16953 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp5

Human homologs

Human Homolog		IGFBP5, insulin-like growth factor binding protein 5
NCBI Gene ID		3488
neXtProt AC		NX_P24593
Human Synonyms		IBP5
Human Chr (Location)		2q33-q36; chr2:217536828-217560272 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cellular response to cAMP, cellular response to organic cyclic compound, ...
Component	extracellular region, insulin-like growth factor binding protein complex
Function	fibronectin binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (48 records)
Data Summary: Results (244)    Tissues (147)    Images (76)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	199
Northern blot	19
RT-PCR	26

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(4) cDNA(23) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017306 (Evidence)
Ensembl Gene Model	ENSMUSG00000026185 (Evidence)
Entrez Gene	16011 (Evidence)
DFCI	TC1572247, TC1602155, TC1613706, TC1649942, TC1712962
DoTS	DT.101397514, DT.101720902, DT.101720903, DT.94128092, DT.94128140, DT.94388924
Consensus CDS Project	CCDS15037.1
International Mouse Knockout Project Status	Igfbp5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017306	VEGA Gene Model | MGI Sequence Detail	16953	C57BL/6J
transcript	OTTMUST00000042008	VEGA | MGI Sequence Detail	6006	Not Applicable
polypeptide	OTTMUSP00000018888	VEGA | MGI Sequence Detail	271	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(111 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR009168	Insulin-like growth factor binding protein
InterPro	IPR012213	Insulin-like growth factor binding protein 5
InterPro	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000716	Thyroglobulin type-1
Protein Ontology	PR:000008951	insulin-like growth factor-binding protein 5

References

(Earliest) J:12803 Schuller AG, et al., Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
(Latest) J:192641 Okano J, et al., Cutaneous retinoic acid levels determine hair follicle development and downgrowth. J Biol Chem. 2012 Nov 16;287(47):39304-15
All references(100)

Other accession IDs

MGD-MRK-11237, MGI:2138187, MGI:2138571