Igfbp4
Gene Detail

Symbol Name ID

Igfbp4 insulin-like growth factor binding protein 4 MGI:96439

Synonyms

Band 3A, Deb2, IGFBP-4

Feature Type

protein coding gene

Genetic Map

Chromosome 11

62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:99041244-99054392 bp, + strand From VEGA annotation of GRCm38   13149 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp4

Human homologs

Human Homolog		IGFBP4, insulin-like growth factor binding protein 4
NCBI Gene ID		3487
neXtProt AC		NX_P22692
Human Synonyms		BP-4, HT29-IGFBP, IBP4, IGFBP-4
Human Chr (Location)		17q12-q21.1; chr17:38599676-38613982 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit a similar reduction in birth and postnatal body weight, and show impaired glucose homeostasis relative to wild-type controls.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of MAPK cascade, ...
Component	extracellular region, extracellular space
Function	growth factor binding, insulin-like growth factor binding

External Resources: FuncBase

Expression

Literature Summary: (29 records)
Data Summary: Results (68)    Tissues (48)    Images (11)
Theiler Stages: 1, 2, 3, 4, 5, 15, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	20
Northern blot	19
RT-PCR	29

cDNA source data(471)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(477) Genomic(1) cDNA(472) Primer pair(4)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000006441 (Evidence)
Ensembl Gene Model	ENSMUSG00000017493 (Evidence)
Entrez Gene	16010 (Evidence)
UniGene	233799
DFCI	TC1573108
DoTS	DT.101159138, DT.60118486, DT.94265309
NIA Mouse Gene Index	U013322
Consensus CDS Project	CCDS25371.1
International Mouse Knockout Project Status	Igfbp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006441	VEGA Gene Model | MGI Sequence Detail	13149	C57BL/6J
transcript	OTTMUST00000014712	VEGA | MGI Sequence Detail	3831	Not Applicable
polypeptide	OTTMUSP00000006838	VEGA | MGI Sequence Detail	254	Not Applicable

All sequences(54) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009168	Insulin-like growth factor binding protein
InterPro	IPR022327	Insulin-like growth factor-binding protein 4
InterPro	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000716	Thyroglobulin type-1
Protein Ontology	PR:000008950	insulin-like growth factor-binding protein 4

References

(Earliest) J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
(Latest) J:187514 Shibata S, et al., An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible. Eur J Histochem. 2012;56(2):e23
All references(83)

Other accession IDs

MGD-MRK-11236, MGI:1349476, MGI:2144326