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Igfbp4
Gene Detail
 Symbol
Name
ID
Igfbp4
insulin-like growth factor binding protein 4
MGI:96439
Synonyms Band 3A, Deb2, IGFBP-4
Feature Type protein coding gene
Genetic Map
Chromosome 11
62.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:99041244-99054392 bp, + strand
From VEGA annotation of GRCm38

  13149 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: insulin-like growth factor binding protein
Gene Tree: Igfbp4

Human
homologs
Human Homolog IGFBP4, insulin-like growth factor binding protein 4
NCBI Gene ID 3487
neXtProt AC  NX_P22692
Human Synonyms  BP-4, HT29-IGFBP, IBP4, IGFBP-4
Human Chr (Location)  17q12-q21.1; chr17:40443424-40457730 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for a knock-out allele exhibit a similar reduction in birth and postnatal body weight, and show impaired glucose homeostasis relative to wild-type controls.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of MAPK cascade, ...
Component extracellular region, extracellular space
Function growth factor binding, insulin-like growth factor binding
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (68)    Tissues (48)    Images (11)
Theiler Stages: 1, 2, 3, 4, 5, 15, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 20
Northern blot 19
RT-PCR 29
cDNA source data(478)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(484) Genomic(1) cDNA(479) Primer pair(4)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000006441 (Evidence)
Ensembl Gene ModelENSMUSG00000017493 (Evidence)
Entrez Gene16010 (Evidence)
UniGene233799
DFCITC1573108
DoTSDT.101159138, DT.60118486, DT.94265309
NIA Mouse Gene IndexU013322
Consensus CDS ProjectCCDS25371.1
International Mouse Knockout Project StatusIgfbp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006441 VEGA Gene Model | MGI Sequence Detail 13149 C57BL/6J ±  kb
transcript OTTMUST00000014712 VEGA | MGI Sequence Detail 3831 Not Applicable 
polypeptide OTTMUSP00000006838 VEGA | MGI Sequence Detail 254 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009168 Insulin-like growth factor binding protein
InterPro IPR022327 Insulin-like growth factor-binding protein 4
InterPro IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000008950 insulin-like growth factor-binding protein 4
References (Earliest) J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
(Latest) J:201076 Okano T, et al., Expression of insulin-like growth factor binding proteins during mouse cochlear development. Dev Dyn. 2013 Oct;242(10):1210-21
All references(87)
Other
accession IDs
MGD-MRK-11236, MGI:1349476, MGI:2144326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory