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Cd79b Gene Detail
Summary
  • Symbol
    Cd79b
  • Name
    CD79B antigen
  • Synonyms
    B29, Igb, Igbeta, Ig-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96431
    NCBI Gene: 15985
  • Gene Overview
    MyGene.info: CD79B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:106311341-106314762 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3422 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 68.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CD79B, CD79b molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD79B, CD79b molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGM6, B29, IGB
  • Links
    NCBI Gene ID: 974
    neXtProt AC: NX_P40259
    UniProt: P40259

  • Chr Location
    17q23.3; chr17:63928738-63932344 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CD79B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 7 alleles in 5 genetic backgrounds
    10 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003415 VEGA Gene Model | MGI Sequence Detail 3422 C57BL/6J ±  kb
    transcript OTTMUST00000007187 VEGA | MGI Sequence Detail 1431 Not Applicable  
    polypeptide OTTMUSP00000003448 VEGA | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      40 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 33
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11225
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:17556 Hermanson GG, et al., B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6890-4
    • Latest
      J:251936 Veselits M, et al., Igbeta ubiquitination activates PI3K signals required for endosomal sorting. J Exp Med. 2017 Dec 4;214(12):3775-3790

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory