Cd79b
Gene Detail

Symbol Name ID

Cd79b CD79B antigen MGI:96431

Synonyms

B29, Igb, Igbeta, Ig-beta

Feature Type

protein coding gene

Genetic Map

Chromosome 11

68.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:106311341-106314762 bp, - strand From VEGA annotation of GRCm38   3422 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd79b ± 2 cM)

Gene Tree: Cd79b

Human ortholog

CD79B CD79b molecule, immunoglobulin-associated beta NCBI Gene ID 974
Human Synonyms: AGM6, B29, IGB
Human Chr17:62006098-62009704 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CD79B (1)

Alleles and phenotypes

All alleles(13) : Targeted(10) Gene trapped(2) Spontaneous(1)
 

Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	B cell receptor signaling pathway, cell surface receptor signaling pathway
Component	B cell receptor complex, external side of plasma membrane, ...
Function	protein binding, transmembrane signaling receptor activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (47)    Images (1)
Theiler Stages: 22, 23, 28

Assay Type	Results
RT-PCR	55

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(1) cDNA(33) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003415 (Evidence)
Ensembl Gene Model	ENSMUSG00000040592 (Evidence)
Entrez Gene	15985 (Evidence)
UniGene	2987
DFCI	TC1581283
DoTS	DT.529403
NIA Mouse Gene Index	U033541
PDB	3KHO, 3KHQ
Consensus CDS Project	CCDS48960.1
International Mouse Knockout Project Status	Cd79b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003415	VEGA Gene Model | MGI Sequence Detail	3422	C57BL/6J
transcript	OTTMUST00000007187	VEGA | MGI Sequence Detail	1431	Not Applicable
polypeptide	OTTMUSP00000003448	VEGA | MGI Sequence Detail	288	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR003110	Phosphorylated immunoreceptor signaling ITAM
Protein Ontology	PR:000001286	B-cell antigen receptor complex-associated protein beta chain

References

(Earliest) J:17556 Hermanson GG, et al., B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6890-4
(Latest) J:179254 Patterson HC, et al., Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. J Immunol. 2011 Sep 15;187(6):2853-8
All references(62)

Other accession IDs

MGD-MRK-11225