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Ide Gene Detail
Summary
  • Symbol
    Ide
  • Name
    insulin degrading enzyme
  • Synonyms
    1300012G03Rik, 4833415K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96412
    NCBI Gene: 15925
  • Gene Overview
    MyGene.info: IDE
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37268741-37334544 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.24 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    604 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96412
protein coding gene Chr19:37268741-37337852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025079
protein coding gene Chr19:36212683-36313914 (-)
A/J MGP_AJ_G0025055
protein coding gene Chr19:34470219-34566938 (-)
AKR/J MGP_AKRJ_G0025023
protein coding gene Chr19:35655043-35748865 (-)
BALB/cJ MGP_BALBcJ_G0025053
protein coding gene Chr19:34560001-34653394 (-)
C3H/HeJ MGP_C3HHeJ_G0024812
protein coding gene Chr19:35705252-35799670 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025494
protein coding gene Chr19:37275745-37378863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022912
protein coding gene Chr19:33835286-33932058 (-)
CAST/EiJ MGP_CASTEiJ_G0024279
protein coding gene Chr19:35550543-35646254 (-)
CBA/J MGP_CBAJ_G0024789
protein coding gene Chr19:39012258-39110704 (-)
DBA/2J MGP_DBA2J_G0024921
protein coding gene Chr19:34328467-34421159 (-)
FVB/NJ MGP_FVBNJ_G0024882
protein coding gene Chr19:34140588-34231666 (-)
LP/J MGP_LPJ_G0025007
protein coding gene Chr19:36313933-36414063 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024913
protein coding gene Chr19:38830546-38925996 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025552
protein coding gene Chr19:35734676-35828601 (-)
PWK/PhJ MGP_PWKPhJ_G0024031
protein coding gene Chr19:34174369-34266932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023831
protein coding gene Chr19:34572230-34661610 (-)
WSB/EiJ MGP_WSBEiJ_G0024346
protein coding gene Chr19:35822227-35917283 (-)



Homology
more
  • Human Ortholog
    IDE, insulin degrading enzyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IDE, insulin degrading enzyme
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INSULYSIN
  • Links
    NCBI Gene ID: 3416
    neXtProt AC: NX_P14735
    UniProt: P14735

  • Chr Location
    10q23.33; chr10:92451684-92574484 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption of this gene display beta amyloid accumulations in the brain, hyperinsulinemia and glucose intolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15925 NCBI Gene Model | MGI Sequence Detail 65804 C57BL/6J ±  kb
    transcript NM_031156 RefSeq | MGI Sequence Detail 5087 C57BL/6  
    polypeptide Q9JHR7 UniProt | EBI | MGI Sequence Detail 1019 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 171
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11179, MGI:1914150, MGI:1921015, MGI:2147459, MGI:2147575
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:11022 Affholter JA, et al., Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol. 1990 Aug;4(8):1125-35
    • Latest
      J:240127 Hogan MF, et al., Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro. Endocrinology. 2016 Sep;157(9):3462-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory