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Ide Gene Detail
Summary
  • Symbol
    Ide
  • Name
    insulin degrading enzyme
  • Synonyms
    1300012G03Rik, 4833415K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96412
    NCBI Gene: 15925
  • Gene Overview
    MyGene.info: IDE
Location & Maps
more
  • Sequence Map
    Chr19:37268743-37337852 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69110 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IDE, insulin degrading enzyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IDE, insulin degrading enzyme
    Orthology source: HGNC, HomoloGene
  • Synonyms
    INSULYSIN
  • Links
    NCBI Gene ID: 3416
    neXtProt AC: NX_P14735

  • Chr Location
    10q23-q25; chr10:92451684-92574095 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    64
  • Gene trapped
    61
  • Targeted
    2
  • Transgenic
    1
Mice homozygous for a disruption of this gene display beta amyloid accumulations in the brain, hyperinsulinemia and glucose intolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029864 VEGA Gene Model | MGI Sequence Detail 69110 C57BL/6J ±  kb
transcript OTTMUST00000074112 VEGA | MGI Sequence Detail 4962 Not Applicable  
polypeptide OTTMUSP00000038463 VEGA | MGI Sequence Detail 987 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    634 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 172
    cDNA 170
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-11179, MGI:1914150, MGI:1921015, MGI:2147459, MGI:2147575
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:11022 Affholter JA, et al., Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol. 1990 Aug;4(8):1125-35
  • Latest
    J:213208 Maianti JP, et al., Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 2014 Jul 3;511(7507):94-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory