Ide
Gene Detail

Symbol Name ID

Ide insulin degrading enzyme MGI:96412

Synonyms

1300012G03Rik, 4833415K22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 19

32.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr19:37268743-37337852 bp, - strand From VEGA annotation of GRCm38   69110 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ide ± 2 cM)

Protein SuperFamily: insulin-degrading enzyme (IDE)/zinc protease
Gene Tree: Ide

Human ortholog

IDE insulin-degrading enzyme NCBI Gene ID 3416
Human Synonyms: INSULYSIN
Human Chr10:94211441-94333852 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(63) : Targeted(2) Gene trapped(61)
 

Mice homozygous for a disruption of this gene display beta amyloid accumulations in the brain, hyperinsulinemia and glucose intolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (62 annotations)

Process	ATP catabolic process, beta-amyloid metabolic process, ...
Component	cell surface, cytoplasm, ...
Function	ATPase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (445)    Tissues (168)    Images (49)
Theiler Stages: 17, 21, 22, 23

Assay Type	Results
RNA in situ	445

cDNA source data(169)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(173) cDNA(171) Primer pair(1) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000029864 (Evidence)
Ensembl Gene Model	ENSMUSG00000056999 (Evidence)
Entrez Gene	15925 (Evidence)
UniGene	28366
DFCI	TC1574845, TC1612095, TC1674779, TC1682511, TC1685925
DoTS	DT.102557750, DT.110848178, DT.55114235, DT.91439316, DT.97345293
NIA Mouse Gene Index	U149447
EC	3.4.24.56
International Mouse Knockout Project Status	Ide

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029864	VEGA Gene Model | MGI Sequence Detail	69110	C57BL/6J
transcript	OTTMUST00000074112	VEGA | MGI Sequence Detail	4962	Not Applicable
polypeptide	OTTMUSP00000038463	VEGA | MGI Sequence Detail	987	Not Applicable

All sequences(45) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(597 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like, metal-binding
InterPro	IPR011237	Peptidase M16, core
InterPro	IPR007863	Peptidase M16, C-terminal
InterPro	IPR011765	Peptidase M16, N-terminal
InterPro	IPR001431	Peptidase M16, zinc-binding site
Protein Ontology	PR:000008886	insulin-degrading enzyme

References

(Earliest) J:11022 Affholter JA, et al., Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol. 1990 Aug;4(8):1125-35
(Latest) J:184757 Kim YG, et al., Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8523-7
All references(55)

Other accession IDs

MGD-MRK-11179, MGI:1914150, MGI:1921015, MGI:2147459, MGI:2147575