Idd5 QTL Detail

Summary

• Symbol
  Idd5
• Name
  insulin dependent diabetes susceptibility 5
• Synonyms
  Idd-5

• Feature Type
  QTL
• IDs
  MGI:96407
  NCBI Gene: 110656
• Candidate Genes
  3 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 1, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  6 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 3 alleles in 3 genetic backgrounds
  4 phenotypes from multigenic genotypes
  19 phenotype references
  

• All Mutations and Alleles
  9
• QTL
  9
• Find Mice (IMSR)
  14 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  110656

Other
Accession IDs

MGD-MRK-11162, MGD-MRK-11174

References

• Summaries
  All 32

  Phenotypes 19
• Earliest
  J:11443 Cornall RJ, et al., Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1 [see comments]. Nature. 1991 Sep 19;353(6341):262-5
• Latest
  J:317217 Garrigan E, et al., Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice. Genet Epigenet. 2015;7:5-17

Candidate Genes for Idd5:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Bcl2	Chr1:106465908-106642004 (-)	J:71276	The authors mention the following genes mapping near Idd5 as possible candidates: Bcl2, Casp8, and Ctla4.
Casp8	Chr1:58834533-58886662 (+)	J:71276	The authors mention the following genes mapping near Idd5 as possible candidates: Bcl2, Casp8, and Ctla4.
Ctla4	Chr1:60948184-60954991 (+)	J:71276	The authors mention the following genes mapping near Idd5 as possible candidates: Bcl2, Casp8, and Ctla4.