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Icam2 Gene Detail
Summary
  • Symbol
    Icam2
  • Name
    intercellular adhesion molecule 2
  • Synonyms
    CD102, Icam-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96394
    NCBI Gene: 15896
  • Gene Overview
    MyGene.info: ICAM2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106377656-106388075 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 69.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96394
protein coding gene Chr11:106377656-106388123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019307
protein coding gene Chr11:109667142-109679084 (-)
A/J MGP_AJ_G0019275
protein coding gene Chr11:105000779-105011889 (-)
AKR/J MGP_AKRJ_G0019244
protein coding gene Chr11:108132761-108143524 (-)
BALB/cJ MGP_BALBcJ_G0019249
protein coding gene Chr11:105409683-105420017 (-)
C3H/HeJ MGP_C3HHeJ_G0019058
protein coding gene Chr11:108418824-108431162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019699
protein coding gene Chr11:113023197-113035130 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017323
protein coding gene Chr11:102278517-102288819 (-)
CAST/EiJ MGP_CASTEiJ_G0018611
protein coding gene Chr11:109485311-109497257 (-)
CBA/J MGP_CBAJ_G0019027
protein coding gene Chr11:117733690-117743806 (-)
DBA/2J MGP_DBA2J_G0019139
protein coding gene Chr11:104470708-104481107 (-)
FVB/NJ MGP_FVBNJ_G0019130
protein coding gene Chr11:103977088-103987594 (-)
LP/J MGP_LPJ_G0019209
protein coding gene Chr11:110112151-110122553 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019160
protein coding gene Chr11:117001785-117012826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019736
protein coding gene Chr11:108621442-108632404 (-)
PWK/PhJ MGP_PWKPhJ_G0018376
protein coding gene Chr11:105568173-105578629 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018167
protein coding gene Chr11:108397564-108409330 (-)
WSB/EiJ MGP_WSBEiJ_G0018662
protein coding gene Chr11:108590189-108600587 (-)



Homology
more
  • Human Ortholog
    ICAM2, intercellular adhesion molecule 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ICAM2, intercellular adhesion molecule 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD102
  • Links
    NCBI Gene ID: 3384
    neXtProt AC: NX_P13598
    UniProt: P13598

  • Chr Location
    17q23.3; chr17:64002595-64020634 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in increased respiratory responsiveness due to an increased accumulation of eosinophils in the lung interstitium and a concomittant delay in the increase of eosinophils in the airway lumen during the development of an allergic inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001029 Ensembl Gene Model | MGI Sequence Detail 10420 C57BL/6J ±  kb
transcript ENSMUST00000001055 Ensembl | MGI Sequence Detail 1282 Not Applicable  
polypeptide ENSMUSP00000001055 Ensembl | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001358 intercellular adhesion molecule 2
  • PDB
  • InterPro Domains
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003988 Intercellular adhesion molecule
    IPR015653 Intercellular adhesion molecule 2
    IPR013768 Intercellular adhesion molecule, N-terminal
    IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
Molecular
Reagents
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  • All nucleic 37
    Genomic 6
    cDNA 29
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11147, MGD-MRK-11150
References
more
  • Summaries
    All 74
    Developmental Gene Expression 19
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:2867 Xu H, et al., Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. J Immunol. 1992 Oct 15;149(8):2650-5
  • Latest
    J:269436 Sabbagh MF, et al., Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells. Elife. 2018 Sep 6;7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory