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Ica1
Gene Detail
Symbol

Name
ID
Ica1
islet cell autoantigen 1
MGI:96391
Synonyms
69kDa, ICA69
Feature Type
protein coding gene
Genetic Map
Chromosome 6
4.38 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr6:8630527-8778488 bp, - strand
From VEGA annotation of GRCm38

  147962 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7777  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: islet cell autoantigen p69 (ICA69)
Gene Tree: Ica1

Human
homologs
Human Homolog ICA1, islet cell autoantigen 1, 69kDa
NCBI Gene ID 3382
neXtProt AC  NX_Q05084
Human Synonyms  ICA69, ICAp69
Human Chr (Location)  7p22; chr7:8113184-8262612 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in diabetes and spontaneous lethality at 4-5 months of age on a NOD background, however mice on a 129/Sv background are normal. Onset of diabetes starts 4 weeks later than wild-type NOD mice and mutants are resistant to cyclophospamide-accelerated diabetes.
 
Interactions
Ica1 interacts with 35 markers (Mir133a-1, Mir133a-2, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process neurotransmitter transport, regulation of neurotransmitter secretion, ...
Component cell junction, cytoplasm, ...
Function protein domain specific binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (207)    Tissues (42)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 161
Northern blot 8
Western blot 7
RT-PCR 18
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) Genomic(11) cDNA(50) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023181 (Evidence)
Ensembl Gene ModelENSMUSG00000062995 (Evidence)
Entrez Gene15893 (Evidence)
UniGene275683
DFCITC1578280, TC1594153, TC1595263, TC1595464, TC1699830
DoTSDT.101365272, DT.491693, DT.60118098, DT.91447097
NIA Mouse Gene IndexU027039
Consensus CDS ProjectCCDS19911.1
International Mouse Knockout Project StatusIca1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023181 VEGA Gene Model | MGI Sequence Detail 147962 C57BL/6J ±  kb
transcript OTTMUST00000056071 VEGA | MGI Sequence Detail 1876 Not Applicable 
polypeptide OTTMUSP00000026902 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(14) UniProt(10)
Polymorphisms
PCR(1) : SNPs within 2kb(1210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010504 Arfaptin homology (AH) domain
InterPro IPR027267 Arfaptin homology (AH) domain/BAR domain
InterPro IPR024114 Islet cell autoantigen 1/Ica1-like
InterPro IPR006723 Islet cell autoantigen Ica1, C-terminal
Protein Ontology PR:000001870 islet cell autoantigen 1
References
(Earliest) J:13253 Pietropaolo M, et al., Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin Invest. 1993 Jul;92(1):359-71
(Latest) J:197677 Cao M, et al., PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol. 2013;11(4):e1001541
All references(41)
Other
accession IDs
MGD-MRK-11145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory