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Ibsp
Gene Detail
Symbol

Name
ID
Ibsp
integrin binding sialoprotein
MGI:96389
Synonyms
bone sialoprotein, BSP, Bsp2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
50.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:104299171-104311469 bp, + strand
From VEGA annotation of GRCm38

  12299 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IBSP
Protein SuperFamily: bone sialoprotein
Gene Tree: Ibsp

Human
homologs
IBSP, integrin-binding sialoprotein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3381
neXtProt AC: NX_P21815

Human Synonyms: BNSP, BSP, BSP-II, SP-II

Human Chr (Location): 4q21.1; chr4:87799550-87812449 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced body weight/size and impaired long bone growth and mineralization, concomitant with severely reduced bone formation.
 
Interactions
Ibsp interacts with 187 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process biomineral tissue development, bone mineralization, ...
Component extracellular region, extracellular space, ...
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (158)    Tissues (62)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 129
Northern blot 11
RT-PCR 16
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ibsp    NEW 
Molecular
reagents
All nucleic(30) cDNA(22) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021399 (Evidence)
Ensembl Gene Model ENSMUSG00000029306 (Evidence)
Entrez Gene 15891 (Evidence)
UniGene 4987
DFCI TC1580472
DoTS DT.101370952, DT.40158421
NIA Mouse Gene Index U005893
Consensus CDS Project CCDS19485.1
International Mouse Phenotyping Consortium Status Ibsp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021399 VEGA Gene Model | MGI Sequence Detail 12299 C57BL/6J ±  kb
transcript OTTMUST00000050727 VEGA | MGI Sequence Detail 2068 Not Applicable 
polypeptide OTTMUSP00000023751 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008412 Bone sialoprotein II
Protein Ontology PR:000008878 bone sialoprotein 2
References
(Earliest) J:16823 Young MF, et al., Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping. Mamm Genome. 1994 Feb;5(2):108-11
(Latest) J:217455 Holm E, et al., Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015 Feb;71:145-54
All references(120)
Other
accession IDs
MGD-MRK-11143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory