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Ibsp
Gene Detail
 Symbol
Name
ID
Ibsp
integrin binding sialoprotein
MGI:96389
Synonyms bone sialoprotein, BSP, Bsp2
Feature Type protein coding gene
Genetic Map
Chromosome 5
50.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:104299171-104311469 bp, + strand
From VEGA annotation of GRCm38

  12299 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: bone sialoprotein
Gene Tree: Ibsp

Human
homologs
Human Homolog IBSP, integrin-binding sialoprotein
NCBI Gene ID 3381
neXtProt AC  NX_P21815
Human Synonyms  BNSP, BSP, BSP-II, SP-II
Human Chr (Location)  4q21.1; chr4:87799550-87812449 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced body weight/size and impaired long bone growth and mineralization, concomitant with severely reduced bone formation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process biomineral tissue development, cell adhesion, ...
Component extracellular region, extracellular space, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (154)    Tissues (59)    Images (36)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 125
Northern blot 11
RT-PCR 16
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(29) cDNA(22) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021399 (Evidence)
Ensembl Gene ModelENSMUSG00000029306 (Evidence)
Entrez Gene15891 (Evidence)
UniGene4987
DFCITC1580472
DoTSDT.101370952, DT.40158421
NIA Mouse Gene IndexU005893
Consensus CDS ProjectCCDS19485.1
International Mouse Knockout Project StatusIbsp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021399 VEGA Gene Model | MGI Sequence Detail 12299 C57BL/6J ±  kb
transcript OTTMUST00000050727 VEGA | MGI Sequence Detail 2068 Not Applicable 
polypeptide OTTMUSP00000023751 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008412 Bone sialoprotein II
Protein Ontology PR:000008878 bone sialoprotein 2
References (Earliest) J:16823 Young MF, et al., Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping. Mamm Genome. 1994 Feb;5(2):108-11
(Latest) J:195901 Ehlen H, Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2013;28(2):246-59
All references(113)
Other
accession IDs
MGD-MRK-11143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory