Hyal1
Gene Detail

Symbol Name ID

Hyal1 hyaluronoglucosaminidase 1 MGI:96298

Synonyms

Hyal-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

58.17 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr9:107576927-107581710 bp, + strand From VEGA annotation of GRCm38   4784 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: hyaluronidase
Gene Tree: Hyal1

Human homologs

Human Homolog		HYAL1, hyaluronoglucosaminidase 1
NCBI Gene ID		3373
neXtProt AC		NX_Q12794
Human Synonyms		HYAL-1, LUCA1, NAT6
Human Chr (Location)		3p21.3-p21.2; chr3:50337320-50349812 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HYAL1

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous null mice display a progressive osteoarthritis associated with bony outgrowths, early loss of articular cartilage proteoglycans and accumulation of hyaluronan (HA) in the cartilage of knee joints, but show no signs of non-skeletal tissue GAG accumulation or increased serum HA levels.

 
Human Diseases Modeled Using Mouse Hyal1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	carbohydrate metabolic process, cell death, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	catalytic activity, hyaluronan synthase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (98)    Tissues (96)   
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	4

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028838 (Evidence)
Ensembl Gene Model	ENSMUSG00000010051 (Evidence)
Entrez Gene	15586 (Evidence)
EC	3.2.1.35
Consensus CDS Project	CCDS23497.1
International Mouse Knockout Project Status	Hyal1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028838	VEGA Gene Model | MGI Sequence Detail	4784	C57BL/6J
transcript	OTTMUST00000071415	VEGA | MGI Sequence Detail	3014	Not Applicable
polypeptide	OTTMUSP00000036591	VEGA | MGI Sequence Detail	462	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR017853	Glycoside hydrolase, superfamily
InterPro	IPR018155	Hyaluronidase
Protein Ontology	PR:000008847	hyaluronidase-1

References

(Earliest) J:9611 Fiszer-Szafarz B, et al., Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet. 1989 Jan;15(1):79-83
(Latest) J:185446 Gushulak L, et al., Hyaluronidase 1 and beta-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation. J Biol Chem. 2012 May 11;287(20):16689-97
All references(43)

Other accession IDs

MGD-MRK-11032, MGD-MRK-11033