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Hyal1
Gene Detail
 Symbol
Name
ID
Hyal1
hyaluronoglucosaminidase 1
MGI:96298
Synonyms Hyal-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
58.17 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:107576927-107581710 bp, + strand
From VEGA annotation of GRCm38

  4784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: hyaluronidase
Gene Tree: Hyal1

Human
homologs
Human Homolog HYAL1, hyaluronoglucosaminidase 1
NCBI Gene ID 3373
neXtProt AC  NX_Q12794
Human Synonyms  HYAL-1, LUCA1, NAT6
Human Chr (Location)  3p21.3-p21.2; chr3:50299889-50312381 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HYAL1
Alleles
and
phenotypes
All alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display a progressive osteoarthritis associated with bony outgrowths, early loss of articular cartilage proteoglycans and accumulation of hyaluronan (HA) in the cartilage of knee joints, but show no signs of non-skeletal tissue GAG accumulation or increased serum HA levels.
 
Human Diseases Modeled Using Mouse Hyal1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process carbohydrate metabolic process, cell death, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function catalytic activity, hyaluronan synthase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (99)    Tissues (97)    Images (1)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 95
RT-PCR 4
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028838 (Evidence)
Ensembl Gene ModelENSMUSG00000010051 (Evidence)
Entrez Gene15586 (Evidence)
EC3.2.1.35
Consensus CDS ProjectCCDS23497.1
International Mouse Knockout Project StatusHyal1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028838 VEGA Gene Model | MGI Sequence Detail 4784 C57BL/6J ±  kb
transcript OTTMUST00000071415 VEGA | MGI Sequence Detail 3014 Not Applicable 
polypeptide OTTMUSP00000036591 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR018155 Hyaluronidase
Protein Ontology PR:000008847 hyaluronidase-1
References (Earliest) J:9611 Fiszer-Szafarz B, et al., Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet. 1989 Jan;15(1):79-83
(Latest) J:185446 Gushulak L, et al., Hyaluronidase 1 and beta-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation. J Biol Chem. 2012 May 11;287(20):16689-97
All references(44)
Other
accession IDs
MGD-MRK-11032, MGD-MRK-11033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory