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Htr5b
Gene Detail
 Symbol
Name
ID
Htr5b
5-hydroxytryptamine (serotonin) receptor 5B
MGI:96284
Feature Type protein coding gene
Genetic Map
Chromosome 1
52.98 cM, cytoband E4-G
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr1:121509842-121528465 bp, - strand
From VEGA annotation of GRCm38

  18624 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74951  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 cattle

Protein SuperFamily: 5-hydroxytryptamine receptor 5
Gene Tree: Htr5b

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype
 
Interactions
Htr5b interacts with 70 markers (Mir15b, Mir34a, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process G-protein coupled receptor signaling pathway, serotonin receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function drug binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (85)    Tissues (66)    Images (14)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 39
RT-PCR 46
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021025 (Evidence)
Ensembl Gene ModelENSMUSG00000050534 (Evidence)
Entrez Gene15564 (Evidence)
UniGene4833
DFCITC1591708
DoTSDT.87040584
NIA Mouse Gene IndexU021709
Consensus CDS ProjectCCDS15239.1
International Mouse Knockout Project StatusHtr5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021025 VEGA Gene Model | MGI Sequence Detail 18624 C57BL/6J ±  kb
transcript OTTMUST00000049715 VEGA | MGI Sequence Detail 1935 Not Applicable 
polypeptide OTTMUSP00000023087 VEGA | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000431 5-Hydroxytryptamine 5B receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001170 5-hydroxytryptamine receptor 5B
References (Earliest) J:15791 Matthes H, et al., Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol. 1993 Mar;43(3):313-9
(Latest) J:186771 Tanaka KF, et al., Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Rep. 2012 Aug 30;2(2):397-406
All references(40)
Other
accession IDs
MGD-MRK-11012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory