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Htr5b Gene Detail
Summary
  • Symbol
    Htr5b
  • Name
    5-hydroxytryptamine (serotonin) receptor 5B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96284
    NCBI Gene: 15564
  • Alliance
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:121437571-121456194 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.98 cM, cytoband E4-G
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96284
protein coding gene Chr1:121437487-121458351 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016411
protein coding gene Chr1:124346588-124367272 (-)
A/J MGP_AJ_G0016394
protein coding gene Chr1:119879701-119897531 (-)
AKR/J MGP_AKRJ_G0016359
protein coding gene Chr1:123392905-123411856 (-)
BALB/cJ MGP_BALBcJ_G0016354
protein coding gene Chr1:120160168-120178740 (-)
C3H/HeJ MGP_C3HHeJ_G0016180
protein coding gene Chr1:123569528-123590771 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016815
protein coding gene Chr1:129079391-129112034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014528
protein coding gene Chr1:113504711-113521238 (-)
CAST/EiJ MGP_CASTEiJ_G0015761
protein coding gene Chr1:122392787-122411161 (-)
CBA/J MGP_CBAJ_G0016153
protein coding gene Chr1:133540048-133566911 (-)
DBA/2J MGP_DBA2J_G0016259
protein coding gene Chr1:118899884-118920465 (-)
FVB/NJ MGP_FVBNJ_G0016258
protein coding gene Chr1:117665598-117683820 (-)
LP/J MGP_LPJ_G0016330
protein coding gene Chr1:125694648-125714968 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016283
protein coding gene Chr1:139227413-139248430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016851
protein coding gene Chr1:123153208-123175297 (-)
PWK/PhJ MGP_PWKPhJ_G0015547
protein coding gene Chr1:117911842-117930103 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015335
protein coding gene Chr1:122067085-122083894 (-)
WSB/EiJ MGP_WSBEiJ_G0015823
protein coding gene Chr1:123029570-123053444 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Htr5b
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for disruptions in this gene display a normal phenotype
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050534 Ensembl Gene Model | MGI Sequence Detail 18624 C57BL/6J ±  kb
transcript ENSMUST00000055884 Ensembl | MGI Sequence Detail 1935 Not Applicable  
polypeptide ENSMUSP00000057212 Ensembl | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 7
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11012
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:276491 Yoshida K, et al., Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior. Nat Neurosci. 2019 May;22(5):770-777

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory