Htr5b
Gene Detail

Symbol Name ID

Htr5b 5-hydroxytryptamine (serotonin) receptor 5B MGI:96284

Feature Type

protein coding gene

Genetic Map

Chromosome 1

52.98 cM, cytoband E4-G
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr1:121509842-121528465 bp, - strand From VEGA annotation of GRCm38   18624 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74951  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: 5-hydroxytryptamine receptor 5
Gene Tree: Htr5b

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for disruptions in this gene display a normal phenotype

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	G-protein coupled receptor signaling pathway, serotonin receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	drug binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (85)    Tissues (66)    Images (14)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	39
RT-PCR	46

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021025 (Evidence)
Ensembl Gene Model	ENSMUSG00000050534 (Evidence)
Entrez Gene	15564 (Evidence)
UniGene	4833
DFCI	TC1591708
DoTS	DT.87040584
NIA Mouse Gene Index	U021709
Consensus CDS Project	CCDS15239.1
International Mouse Knockout Project Status	Htr5b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021025	VEGA Gene Model | MGI Sequence Detail	18624	C57BL/6J
transcript	OTTMUST00000049715	VEGA | MGI Sequence Detail	1935	Not Applicable
polypeptide	OTTMUSP00000023087	VEGA | MGI Sequence Detail	370	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(86 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000431	5-Hydroxytryptamine 5B receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001170	5-hydroxytryptamine receptor 5B

References

(Earliest) J:15791 Matthes H, et al., Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol. 1993 Mar;43(3):313-9
(Latest) J:186771 Tanaka KF, et al., Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Rep. 2012 Aug 30;2(2):397-406
All references(40)

Other accession IDs

MGD-MRK-11012