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Htr5a
Gene Detail
Symbol

Name
ID
Htr5a
5-hydroxytryptamine (serotonin) receptor 5A
MGI:96283
Synonyms
Htr5
Feature Type
protein coding gene
Genetic Map
Chromosome 5
13.24 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:27841947-27855086 bp, + strand
From Ensembl annotation of GRCm38

  13140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HTR5A
Protein SuperFamily: 5-hydroxytryptamine receptor 5
Gene Tree: Htr5a

Human
homologs
HTR5A, 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3361
neXtProt AC: NX_P47898

Human Synonyms: 5-HT5A

Human Chr (Location): 7q36.1; chr7:155070324-155087392 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Radiation induced(4) Targeted(2)
Genomic Mutations involving Htr5a (4)
Incidental mutations (data from Mutagenetix , APF )
 
The are conflicting reports about mice with homozygous null alleles regarding increased exploratory behavior and an abnormal exploratory behavior response to LSD.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Htr5a interacts with 378 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cAMP-mediated signaling, G-protein coupled receptor signaling pathway, ...
Component dendrite, Golgi apparatus, ...
Function G-protein coupled receptor activity, serotonin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (238)    Tissues (95)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 66
RT-PCR 130
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase htr5a    NEW 
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(10) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039106 (Evidence)
Entrez Gene 15563 (Evidence)
UniGene 4835
DFCI TC1592705
DoTS DT.91583363
NIA Mouse Gene Index U005380
Consensus CDS Project CCDS19141.1
International Mouse Phenotyping Consortium Status Htr5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039106 Ensembl Gene Model | MGI Sequence Detail 13140 C57BL/6J ±  kb
transcript ENSMUST00000036227 Ensembl | MGI Sequence Detail 5576 Not Applicable 
polypeptide ENSMUSP00000038884 Ensembl | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001397 5-Hydroxytryptamine 5A receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001169 5-hydroxytryptamine receptor 5A
References
(Earliest) J:3482 Plassat JL, et al., The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. EMBO J. 1992 Dec;11(13):4779-86
(Latest) J:184601 Goodfellow NM, et al., The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse. J Neurosci. 2012 Apr 25;32(17):5804-9
All references(41)
Other
accession IDs
MGD-MRK-11010, MGD-MRK-11011

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory