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Htr5a
Gene Detail
 Symbol
Name
ID
Htr5a
5-hydroxytryptamine (serotonin) receptor 5A
MGI:96283
Synonyms Htr5
Feature Type protein coding gene
Genetic Map
Chromosome 5
13.24 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:27841947-27855086 bp, + strand
From NCBI annotation of GRCm38

  13140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 5
Gene Tree: Htr5a

Human
homologs
Human Homolog HTR5A, 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
NCBI Gene ID 3361
neXtProt AC  NX_P47898
Human Synonyms  5-HT5A
Human Chr (Location)  7q36.1; chr7:155070324-155087392 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(3) Targeted(2)
Genomic Mutations involving Htr5a (3)
Incidental mutations (data from Mutagenetix , APF )
 
The are conflicting reports about mice with homozygous null alleles regarding increased exploratory behavior and an abnormal exploratory behavior response to LSD.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Htr5a interacts with 379 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cAMP-mediated signaling, G-protein coupled receptor signaling pathway, ...
Component dendrite, Golgi apparatus, ...
Function G-protein coupled receptor activity, serotonin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (238)    Tissues (95)    Images (28)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 66
RT-PCR 130
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(10) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000039106 (Evidence)
Entrez Gene15563 (Evidence)
UniGene4835
DFCITC1592705
DoTSDT.91583363
NIA Mouse Gene IndexU005380
Consensus CDS ProjectCCDS19141.1
International Mouse Knockout Project StatusHtr5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15563 NCBI Gene Model | MGI Sequence Detail 13140 C57BL/6J ±  kb
transcript NM_008314 RefSeq | MGI Sequence Detail 5576 C57BL/6 
polypeptide P30966 UniProt | EBI | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001397 5-Hydroxytryptamine 5A receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001169 5-hydroxytryptamine receptor 5A
Graphical View of Protein Domain Structure
References (Earliest) J:3482 Plassat JL, et al., The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. EMBO J. 1992 Dec;11(13):4779-86
(Latest) J:184601 Goodfellow NM, et al., The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse. J Neurosci. 2012 Apr 25;32(17):5804-9
All references(42)
Other
accession IDs
MGD-MRK-11010, MGD-MRK-11011

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory