Htr5a
Gene Detail

Symbol Name ID

Htr5a 5-hydroxytryptamine (serotonin) receptor 5A MGI:96283

Synonyms

Htr5

Feature Type

protein coding gene

Genetic Map

Chromosome 5

13.24 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr5:27841947-27855086 bp, + strand From NCBI annotation of GRCm38   13140 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Htr5a ± 2 cM)

Protein SuperFamily: 5-hydroxytryptamine receptor 5
Gene Tree: Htr5a

Human ortholog

HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled NCBI Gene ID 3361
Human Synonyms: 5-HT5A
Human Chr7:154862546-154877459 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

The are conflicting reports about mice with homozygous null alleles regarding increased exploratory behavior and an abnormal exploratory behavior response to LSD.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	behavior, cAMP-mediated signaling, ...
Component	dendrite, Golgi apparatus, ...
Function	G-protein coupled receptor activity, serotonin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (238)    Tissues (95)    Images (28)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42
In situ reporter (knock in)	66
RT-PCR	130

cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(2) cDNA(10) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000039106 (Evidence)
Entrez Gene	15563 (Evidence)
UniGene	4835
DFCI	TC1592705
DoTS	DT.91583363
NIA Mouse Gene Index	U005380
Consensus CDS Project	CCDS19141.1
International Mouse Knockout Project Status	Htr5a

Sequences

Length	Strain/Species
genomic	15563	NCBI Gene Model | MGI Sequence Detail	13140	C57BL/6J
transcript	NM_008314	RefSeq | MGI Sequence Detail	5576	C57BL/6
polypeptide	P30966	UniProt | EBI | MGI Sequence Detail	357	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001397	5-Hydroxytryptamine 5A receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001169	5-hydroxytryptamine receptor 5A

Graphical View of Protein Domain Structure

References

(Earliest) J:3482 Plassat JL, et al., The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. EMBO J. 1992 Dec;11(13):4779-86
(Latest) J:184601 Goodfellow NM, et al., The native serotonin 5-HT(5A) receptor: electrophysiological characterization in rodent cortex and 5-HT(1A)-mediated compensatory plasticity in the knock-out mouse. J Neurosci. 2012 Apr 25;32(17):5804-9
All references(42)

Other accession IDs

MGD-MRK-11010, MGD-MRK-11011