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Htr3a
Gene Detail
Symbol

Name
ID
Htr3a
5-hydroxytryptamine (serotonin) receptor 3A
MGI:96282
Synonyms
5-HT3 receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 9
26.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:48899214-48911099 bp, - strand
From Ensembl annotation of GRCm38

  11886 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:671  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: HTR3A
Gene Tree: Htr3a

Human
homologs
HTR3A, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3359
neXtProt AC: NX_P46098

Human Synonyms: 5-HT-3, 5-HT3A, 5HT3R, 5-HT3R, HTR3

Human Chr (Location): 11q23.1; chr11:113975075-113990313 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice display a decreased lifespan, cachexia, increased blood urea nitrogen, proteinuria, kidney inflammation, and a hyperdistended and neurogenic urinary bladder. Mice homozygous for a second null mutation display reduced chemical pain persistence responses but are otherwise healthy.
 
Interactions
Htr3a interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cation transmembrane transport, cation transport, ...
Component axon, cell junction, ...
Function extracellular ligand-gated ion channel activity, ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (109)    Tissues (69)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 63
RT-PCR 46
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(6) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032269 (Evidence)
Entrez Gene 15561 (Evidence)
UniGene 4831
DFCI TC1583185, TC1594898, TC1677375
DoTS DT.40156479, DT.91339978
NIA Mouse Gene Index U030825
PDB 4PIR
Consensus CDS Project CCDS52788.1
International Mouse Phenotyping Consortium Status Htr3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032269 Ensembl Gene Model | MGI Sequence Detail 11886 C57BL/6J ±  kb
transcript ENSMUST00000003826 Ensembl | MGI Sequence Detail 2082 Not Applicable 
polypeptide ENSMUSP00000003826 Ensembl | MGI Sequence Detail 489 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008132 5-hydroxytryptamine 3 receptor
InterPro IPR008133 5-hydroxytryptamine 3 receptor, A subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
Protein Ontology PR:000008833 5-hydroxytryptamine receptor 3A
References
(Earliest) J:17543 Maricq AV, et al., Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science. 1991 Oct 18;254(5030):432-7
(Latest) J:220766 Kim K, et al., Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. 2015 Feb;156(2):444-52
All references(64)
Other
accession IDs
MGD-MRK-11009

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory