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Htr3a Gene Detail
Summary
  • Symbol
    Htr3a
  • Name
    5-hydroxytryptamine (serotonin) receptor 3A
  • Synonyms
    5-HT3 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96282
    NCBI Gene: 15561
  • Gene Overview
    MyGene.info: HTR3A
Location & Maps
more
  • Sequence Map
    Chr9:48899214-48911099 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11886 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.53 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HTR3A, 5-hydroxytryptamine receptor 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HTR3A, 5-hydroxytryptamine receptor 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5-HT-3, 5-HT3A, 5HT3R, 5-HT3R, HTR3
  • Links
    NCBI Gene ID: 3359
    neXtProt AC: NX_P46098

  • Chr Location
    11q23.2; chr11:113975075-113990313 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display a decreased lifespan, cachexia, increased blood urea nitrogen, proteinuria, kidney inflammation, and a hyperdistended and neurogenic urinary bladder. Mice homozygous for a second null mutation display reduced chemical pain persistence responses but are otherwise healthy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032269 Ensembl Gene Model | MGI Sequence Detail 11886 C57BL/6J ±  kb
transcript ENSMUST00000003826 Ensembl | MGI Sequence Detail 2082 Not Applicable  
polypeptide ENSMUSP00000003826 Ensembl | MGI Sequence Detail 489 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    212 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008833 5-hydroxytryptamine receptor 3A
  • PDB
  • InterPro Domains
    IPR008132 5-hydroxytryptamine 3 receptor
    IPR008133 5-hydroxytryptamine 3 receptor, A subunit
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
Molecular
Reagents
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  • All nucleic 19
    Genomic 6
    cDNA 12
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11009
References
more
  • Summaries
    All 64
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:17543 Maricq AV, et al., Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science. 1991 Oct 18;254(5030):432-7
  • Latest
    J:235575 Chang W, et al., Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5491-500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory