Htr1d MGI Mouse Gene Detail - MGI:96276 - 5-hydroxytryptamine (serotonin) receptor 1D

Symbol

Htr1d
Name

5-hydroxytryptamine (serotonin) receptor 1D
Synonyms

Gpcr14, Htr1db

Feature Type

protein coding gene
IDs

MGI:96276
NCBI Gene: 15552
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:136150835-136171709 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.74 cM
Mapping Data

12 experiments

SNPs within 2kb

699 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96276	protein coding gene	Chr4:136150835-136171716 (+)
129S1/SvImJ	ENSMUSG00200019249	protein coding gene	Chr4:129568664-129589472 (+)
A/J	ENSMUSG00195039362	protein coding gene	Chr4:130917802-130939265 (+)
AKR/J	ENSMUSG00220045276	protein coding gene	Chr4:129911969-129933461 (+)
BALB/cJ	ENSMUSG00180048609	protein coding gene	Chr4:128551447-128572177 (+)
C3H/HeJ	ENSMUSG00175039158	protein coding gene	Chr4:129571167-129592659 (+)
C57BL/6NJ	ENSMUSG00215051885	protein coding gene	Chr4:131091287-131112175 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026661	protein coding gene	Chr4:126094482-126116309 (+)
CAST/EiJ	ENSTCUG00005046225	protein coding gene	Chr4:130497499-130520139 (+)
CBA/J	ENSMUSG00210052905	protein coding gene	Chr4:129195069-129216572 (+)
DBA/2J	ENSMUSG00185051189	protein coding gene	Chr4:130724771-130745491 (+)
FVB/NJ	ENSMUSG00205024290	protein coding gene	Chr4:128968199-128988916 (+)
JF1/MsJ	ENSUMUG00000014607	protein coding gene	Chr4:131425056-131445849 (+)
LP/J	ENSMUSG00230039797	protein coding gene	Chr4:134506867-134527670 (+)
NOD/ShiLtJ	ENSMUSG00190034551	protein coding gene	Chr4:128956858-128977572 (+)
NZO/HlLtJ	ENSMUSG00225026301	protein coding gene	Chr4:140461837-140482651 (+)
PWK/PhJ	ENSLUMG00010045239	protein coding gene	Chr4:128407674-128429128 (+)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005040629	protein coding gene	Chr4:128859699-128880674 (+)

Human Ortholog

HTR1D, 5-hydroxytryptamine receptor 1D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HTR1D, 5-hydroxytryptamine receptor 1D
Synonyms

5-HT1D, HT1DA, HTR1DA, HTRL, RDC4
Links

HGNC:5289

NCBI Gene ID: 3352

UniProt: P28221
Chr Location

1p36.12; chr1:23190178-23217547 (-) GRCh38

MGI Vertebrate Homology

Htr1d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HTR1D
Gene Tree

Htr1d

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

4
Targeted

6
Genomic Mutations

3 involving Htr1d
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

36
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

153
cDNA Data

9
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN htr1d

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All Sequences

55
RefSeq

14
UniProt

1
CCDS

CCDS18806.1

Ensembl

ENSMUSG00000070687 (Evidence)
NCBI Gene

15552

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070687	Ensembl Gene Model \| MGI Sequence Detail	20875	C57BL/6J	± kb
transcript	ENSMUST00000088677	Ensembl \| MGI Sequence Detail	2904	Not Applicable
polypeptide	ENSMUSP00000086052	Ensembl \| MGI Sequence Detail	374	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001163 5-hydroxytryptamine receptor 1D

(term hierarchy)
InterPro Domains

IPR000505 5-Hydroxytryptamine 1D receptor

IPR002231 5-hydroxytryptamine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q61224 3 sites

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All nucleic 20

Genomic 4

cDNA 10

Primer pair 6

Antibodies 1

Microarray probesets 6

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MGD-MRK-11002, MGD-MRK-11004, MGD-MRK-16348, MGI:2140395, MGI:96278, MGI:99568

Summaries

All 68

Developmental Gene Expression 13

Gene Ontology 8

Phenotypes 15
Earliest

J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
Latest

J:359837 Frolova VS, et al., Serotonin Signaling in Mouse Preimplantation Development: Insights from Transcriptomic and Structural-Functional Analyses. Int J Mol Sci. 2024 Dec 2;25(23)

TSS for Htr1d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39707	Chr4:136151367-136151378 (+)	538 bp
Tssr39708	Chr4:136151885-136151901 (+)	1,058 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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