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Htr1d Gene Detail
Summary
  • Symbol
    Htr1d
  • Name
    5-hydroxytryptamine (serotonin) receptor 1D
  • Synonyms
    Gpcr14, Htr1db
  • Feature Type
    protein coding gene
  • IDs
    MGI:96276
    NCBI Gene: 15552
  • Gene Overview
    MyGene.info: HTR1D
Location & Maps
more
  • Sequence Map
    Chr4:136423524-136444398 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20875 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HTR1D, 5-hydroxytryptamine receptor 1D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTR1D, 5-hydroxytryptamine receptor 1D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-HT1D, HT1DA, HTR1DA, HTRL, RDC4
  • Links
    NCBI Gene ID: 3352
    neXtProt AC: NX_P28221

  • Chr Location
    1p36.3-p34.3; chr1:23191895-23194729 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Htr1d
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009699 VEGA Gene Model | MGI Sequence Detail 20875 C57BL/6J ±  kb
transcript OTTMUST00000022402 VEGA | MGI Sequence Detail 2904 Not Applicable  
polypeptide OTTMUSP00000010214 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    237 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001163 5-hydroxytryptamine receptor 1D
  • InterPro Domains
    IPR000505 5-Hydroxytryptamine 1D receptor
    IPR002231 5-hydroxytryptamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 14
    Genomic 3
    cDNA 8
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-11002, MGD-MRK-11004, MGD-MRK-16348, MGI:2140395, MGI:96278, MGI:99568
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
  • Latest
    J:196760 Enjin A, et al., Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Mol Cell Neurosci. 2012 Mar;49(3):322-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory