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Trmt2a Gene Detail
Summary
  • Symbol
    Trmt2a
  • Name
    TRM2 tRNA methyltransferase 2A
  • Synonyms
    Htf9c
  • Feature Type
    protein coding gene
  • IDs
    MGI:96270
    NCBI Gene: 15547
Location & Maps
more
  • Sequence Map
    Chr16:18248679-18254772 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6094 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.31 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TRMT2A, tRNA methyltransferase 2 homolog A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRMT2A, tRNA methyltransferase 2 homolog A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTF9C
  • Links
    NCBI Gene ID: 27037
    neXtProt AC: NX_Q8IZ69

  • Chr Location
    22q11.21; chr22:20111866-20117295 (-)  GRCh38.p2

Human Diseases
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  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    7
  • Targeted
    13
  • Genomic Mutations
    9 involving Trmt2a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026007 VEGA Gene Model | MGI Sequence Detail 6094 C57BL/6J ±  kb
transcript OTTMUST00000064177 VEGA | MGI Sequence Detail 2367 Not Applicable  
polypeptide OTTMUSP00000031834 VEGA | MGI Sequence Detail 613 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000016680 tRNA (uracil-5-)-methyltransferase homolog A
  • EC
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR010280 (Uracil-5)-methyltransferase family
Molecular
Reagents
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  • All nucleic 48
    Genomic 15
    cDNA 30
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10995
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Diseases 12
    Gene Ontology 4
    Phenotypes 52
  • Earliest
    J:17925 Bird A, et al., A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell. 1985 Jan;40(1):91-9
  • Latest
    J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory