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Ranbp1
Gene Detail
Symbol

Name
ID
Ranbp1
RAN binding protein 1
MGI:96269
Synonyms
Htf9a
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr16:18239784-18248732 bp, - strand
From VEGA annotation of GRCm38

  8949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21600  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ran-specific GTPase-activating protein
Gene Tree: Ranbp1

Human
homologs
Human Homolog   RANBP1, RAN binding protein 1
NCBI Gene ID 5902
neXtProt AC  NX_P43487
Human Synonyms  HTF9A
Human Chr (Location)  22q11.21; chr22:20115938-20127357 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(180) : Gene trapped(168) Targeted(12)
Genomic Mutations involving Ranbp1 (9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal growth retardation, decreased body weight, impaired spermatogenesis, and male infertility.
 
Mutations Annotated to Human Diseases (3)   
Interactions
Ranbp1 interacts with 85 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to leptomycin B, intracellular transport, ...
Component cell projection cytoplasm, centrosome, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (108)    Tissues (54)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 27
RT-PCR 62
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(14) cDNA(70) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026021 (Evidence)
Ensembl Gene ModelENSMUSG00000005732 (Evidence)
Entrez Gene19385 (Evidence)
UniGene235287
DFCITC1572819
NIA Mouse Gene IndexU036857
Consensus CDS ProjectCCDS37280.1
International Mouse Knockout Project StatusRanbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026021 VEGA Gene Model | MGI Sequence Detail 8949 C57BL/6J ±  kb
transcript OTTMUST00000064217 VEGA | MGI Sequence Detail 1085 Not Applicable 
polypeptide OTTMUSP00000031864 VEGA | MGI Sequence Detail 203 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000156 Ran binding domain
Protein Ontology PR:000013709 ran-specific GTPase-activating protein
References
(Earliest) J:17925 Bird A, et al., A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell. 1985 Jan;40(1):91-9
(Latest) J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
All references(57)
Other
accession IDs
MGD-MRK-10994

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory