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Hspa2 Gene Detail
Summary
  • Symbol
    Hspa2
  • Name
    heat shock protein 2
  • Synonyms
    70kDa, Hsp70-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96243
    NCBI Gene: 15512
  • Gene Overview
    MyGene.info: HSPA2
Location & Maps
more
  • Sequence Map
    Chr12:76404176-76406934 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2759 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    HSPA2, heat shock protein family A (Hsp70) member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HSPA2, heat shock protein family A (Hsp70) member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSP70-2, HSP70-3
  • Links
    NCBI Gene ID: 3306
    neXtProt AC: NX_P54652

  • Chr Location
    14q24.1; chr14:64540468-64543237 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Hspa2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit male sterility associated with lack of postmeiotic germ cells and markedly increased frequency of spermatocyte apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059970 Ensembl Gene Model | MGI Sequence Detail 2759 C57BL/6J ±  kb
transcript ENSMUST00000080449 Ensembl | MGI Sequence Detail 2520 Not Applicable  
polypeptide ENSMUSP00000079306 Ensembl | MGI Sequence Detail 633 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008807 heat shock-related 70 kDa protein 2
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain
    IPR029047 Heat shock protein 70kD, peptide-binding domain
Molecular
Reagents
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  • All nucleic 48
    Genomic 12
    cDNA 34
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10959, MGD-MRK-19433
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 17
    Phenotypes 12
  • Earliest
    J:9294 Zakeri ZF, et al., Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. Mol Cell Biol. 1988 Jul;8(7):2925-32
  • Latest
    J:228105 Liu M, et al., SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. Mol Hum Reprod. 2014 Jun;20(6):463-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory