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Hspa2
Gene Detail
 Symbol
Name
ID
Hspa2
heat shock protein 2
MGI:96243
Synonyms 70kDa, Hsp70-2
Feature Type protein coding gene
Genetic Map
Chromosome 12
33.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr12:76404176-76406934 bp, + strand
From Ensembl annotation of GRCm38

  2759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: chaperone HSP70
Gene Tree: Hspa2

Human
homologs
Human Homolog HSPA2, heat shock 70kDa protein 2
NCBI Gene ID 3306
neXtProt AC  NX_P54652
Human Synonyms  HSP70-2, HSP70-3
Human Chr (Location)  14q24.1; chr14:64540468-64543237 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit male sterility associated with lack of postmeiotic germ cells and markedly increased frequency of spermatocyte apoptosis.
 
Interactions
Hspa2 interacts with 150 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process male meiosis, male meiosis I, ...
Component blood microparticle, CatSper complex, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (86)    Tissues (17)    Images (20)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 83
RT-PCR 3
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(12) cDNA(34) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000059970 (Evidence)
Entrez Gene15512 (Evidence)
UniGene296181
DFCITC1578496, TC1587901
DoTSDT.101376688, DT.40140496
NIA Mouse Gene IndexU142424
Consensus CDS ProjectCCDS25993.1
International Mouse Knockout Project StatusHspa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059970 Ensembl Gene Model | MGI Sequence Detail 2759 C57BL/6J ±  kb
transcript ENSMUST00000080449 Ensembl | MGI Sequence Detail 2520 Not Applicable 
polypeptide ENSMUSP00000079306 Ensembl | MGI Sequence Detail 633 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(1)
Polymorphisms RFLP(3) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018181 Heat shock protein 70, conserved site
InterPro IPR013126 Heat shock protein 70 family
Protein Ontology PR:000008807 heat shock-related 70 kDa protein 2
References (Earliest) J:9294 Zakeri ZF, et al., Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. Mol Cell Biol. 1988 Jul;8(7):2925-32
(Latest) J:204898 Akiyama K, et al., A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice. J Biol Chem. 2013 Nov 1;288(44):31830-41
All references(55)
Other
accession IDs
MGD-MRK-10959, MGD-MRK-19433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory