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Hsf2
Gene Detail
Symbol

Name
ID
Hsf2
heat shock factor 2
MGI:96239
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.19 cM, cytoband B3-B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:57486385-57513133 bp, + strand
From Ensembl annotation of GRCm38

  26749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: heat shock transcription factor
Gene Tree: Hsf2

Human
homologs
Human Homolog HSF2, heat shock transcription factor 2
NCBI Gene ID 3298
neXtProt AC  NX_Q03933
Human Synonyms  HSF 2, HSTF 2
Human Chr (Location)  6q22.31; chr6:122399551-122433119 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit increased late-gestational lethality associated with collapsed lateral ventricles and ventricular bleeding. Survivors may show ventricular dilation, sterility in females, and reduced sperm counts in males.
 
Phenotype Images(4)
Interactions
Hsf2 interacts with 166 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (267)    Tissues (161)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 232
In situ reporter (knock in) 9
Northern blot 3
Western blot 11
RT-PCR 12
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(6) cDNA(14) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000019878 (Evidence)
Entrez Gene15500 (Evidence)
DFCITC1584692, TC1588774, TC1615289, TC1623293
DoTSDT.101209436, DT.101344080, DT.481787, DT.94260596
Consensus CDS ProjectCCDS23852.1
International Mouse Knockout Project StatusHsf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019878 Ensembl Gene Model | MGI Sequence Detail 26749 C57BL/6J ±  kb
transcript ENSMUST00000079833 Ensembl | MGI Sequence Detail 2613 Not Applicable 
polypeptide ENSMUSP00000078761 Ensembl | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
InterPro IPR010542 Vertebrate heat shock transcription factor
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008791 heat shock factor protein 2
References
(Earliest) J:11465 Sarge KD, et al., Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev. 1991 Oct;5(10):1902-11
(Latest) J:183020 Shinkawa T, et al., Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Mol Biol Cell. 2011 Oct;22(19):3571-83
All references(61)
Other
accession IDs
MGD-MRK-10953, MGI:2143663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory