About   Help   FAQ
Hsf2 Gene Detail
Summary
  • Symbol
    Hsf2
  • Name
    heat shock factor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96239
    NCBI Gene: 15500
Location & Maps
more
  • Sequence Map
    Chr10:57486385-57513133 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26749 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HSF2, heat shock transcription factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSF2, heat shock transcription factor 2
    Orthology source: HomoloGene
  • Synonyms
    HSF 2, HSTF 2
  • Links
    NCBI Gene ID: 3298
    neXtProt AC: NX_Q03933

  • Chr Location
    6q22.31; chr6:122399551-122433119 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Hsf2
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit increased late-gestational lethality associated with collapsed lateral ventricles and ventricular bleeding. Survivors may show ventricular dilation, sterility in females, and reduced sperm counts in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019878 Ensembl Gene Model | MGI Sequence Detail 26749 C57BL/6J ±  kb
transcript ENSMUST00000079833 Ensembl | MGI Sequence Detail 2613 Not Applicable  
polypeptide ENSMUSP00000078761 Ensembl | MGI Sequence Detail 517 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    192 from dbSNP Build 137
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008791 heat shock factor protein 2
  • InterPro Domains
    IPR000232 Heat shock factor (HSF)-type, DNA-binding
    IPR027712 Heat shock factor protein 2
    IPR027725 Heat shock transcription factor family
    IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 23
    Genomic 6
    cDNA 14
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10953, MGI:2143663
References
more
  • Summaries
    All 58
    Developmental Gene Expression 13
    Gene Ontology 8
    Phenotypes 24
  • Earliest
    J:11465 Sarge KD, et al., Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev. 1991 Oct;5(10):1902-11
  • Latest
    J:215895 Elsing AN, et al., Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. J Cell Biol. 2014 Sep 15;206(6):735-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory