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Hsd3b3 Gene Detail
Summary
  • Symbol
    Hsd3b3
  • Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
  • Synonyms
    9030618K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96235
    NCBI Gene: 15494
  • Member of
    Hsd3b cluster
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:98741523-98763127 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.86 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96235
protein coding gene Chr3:98741476-98765149 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027659
protein coding gene Chr3:99778104-99808403 (-)
A/J MGP_AJ_G0027618
protein coding gene Chr3:96628612-96686551 (-)
AKR/J MGP_AKRJ_G0027583
protein coding gene Chr3:98927258-98944318 (-)
BALB/cJ MGP_BALBcJ_G0027630
protein coding gene Chr3:96422797-96446340 (-)
C3H/HeJ MGP_C3HHeJ_G0027359
protein coding gene Chr3:99275744-99292221 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028073
protein coding gene Chr3:103456189-103507249 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025414
protein coding gene Chr3:92740380-92847881 (-)
CAST/EiJ MGP_CASTEiJ_G0026816
protein coding gene Chr3:98433779-98456281 (-)
CBA/J MGP_CBAJ_G0027334
protein coding gene Chr3:107167777-107194453 (-)
DBA/2J MGP_DBA2J_G0027477
protein coding gene Chr3:95887582-95904924 (-)
FVB/NJ MGP_FVBNJ_G0027446
protein coding gene Chr3:93866516-93871220 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0027476
protein coding gene Chr3:113236045-113263517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028128
protein coding gene Chr3:98489116-98506814 (-)
PWK/PhJ MGP_PWKPhJ_G0026541
protein coding gene Chr3:95657017-95693653 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026365
protein coding gene Chr3:96658788-96672967 (-)
WSB/EiJ MGP_WSBEiJ_G0026896
protein coding gene Chr3:98995367-99068681 (-)



Homology
more
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1
  • Links
    NCBI Gene ID: 3283
    neXtProt AC: NX_P14060
    UniProt: P14060

  • Chr Location
    1p12; chr1:119507112-119515060 (+)  GRCh38.p7

  • Human Ortholog
    HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
    Orthology source: HGNC
  • Synonyms
    HSD3B, HSDB, SDR11E2
  • Links
    NCBI Gene ID: 3284
    neXtProt AC: NX_P26439
    UniProt: P26439

  • Chr Location
    1p12; chr1:119414931-119423039 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HSD3B2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062410 Ensembl Gene Model | MGI Sequence Detail 21605 C57BL/6J ±  kb
transcript ENSMUST00000107019 Ensembl | MGI Sequence Detail 1533 Not Applicable  
polypeptide ENSMUSP00000102633 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 12
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10948, MGI:1918777, MGI:2139796
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:29466 Bain PA, et al., Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8870-4
  • Latest
    J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory