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Hsd3b1
Gene Detail
Symbol

Name
ID
Member of
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
MGI:96233
Hsd3b cluster
Synonyms
D3Ertd383e
Feature Type
protein coding gene
Genetic Map
Chromosome 3
42.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:98852194-98859794 bp, - strand
From VEGA annotation of GRCm38

  7601 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69149  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: bifunctional 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Gene Tree: Hsd3b1

Human
homologs
Human Homolog HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
NCBI Gene ID 3284
neXtProt AC  NX_P26439
Human Synonyms  HSD3B, HSDB, SDR11E2
Human Chr (Location)  1p13.1; chr1:119414931-119423039 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HSD3B2
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hsd3b1 interacts with 64 markers (Mir19b-1, Mir19b-2, Mir31, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (31 records)
Data Summary: Results (296)    Tissues (158)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 112
Western blot 24
RT-PCR 133
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(2) cDNA(48) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006826 (Evidence)
Ensembl Gene ModelENSMUSG00000027871 (Evidence)
Entrez Gene15492 (Evidence)
UniGene140811
DFCITC1578530, TC1756438
DoTSDT.101137856, DT.533971
NIA Mouse Gene IndexU137516
EC1.1.1.145, 5.3.3.1
Consensus CDS ProjectCCDS17670.1
International Mouse Knockout Project StatusHsd3b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006826 VEGA Gene Model | MGI Sequence Detail 7601 C57BL/6J ±  kb
transcript OTTMUST00000015760 VEGA | MGI Sequence Detail 1817 Not Applicable 
polypeptide OTTMUSP00000007240 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(115 from dbSNP Build 137)    SNPs within 2kb including multiple locations(143)
Protein-related
information
ResourceIDDescription
InterPro IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008785 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
References
(Earliest) J:29466 Bain PA, et al., Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8870-4
(Latest) J:205146 Praktiknjo SD, et al., Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice. Endocrinology. 2013 Dec;154(12):4746-56
All references(65)
Other
accession IDs
MGD-MRK-10946, MGI:1196249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory