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Hsd3b1
Gene Detail
Symbol

Name
ID
Member of
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
MGI:96233
Hsd3b cluster
Synonyms
D3Ertd383e
Feature Type
protein coding gene
Genetic Map
Chromosome 3
42.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:98852194-98859794 bp, - strand
From VEGA annotation of GRCm38

  7601 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69149  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HSD3B1, HSD3B2
Protein SuperFamily: bifunctional 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Gene Tree: Hsd3b1

Human
homologs
HSD3B1, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 3283
neXtProt AC: NX_P14060

Human Synonyms: 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1

Human Chr (Location): 1p13.1; chr1:119507124-119515060 (+)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hsd3b1 interacts with 63 markers (Mir19b-1, Mir19b-2, Mir31, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (33 records)
Data Summary: Results (332)    Tissues (167)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 112
Western blot 24
RT-PCR 169
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100490622    NEW 
Molecular
reagents
All nucleic(58) Genomic(2) cDNA(48) Primer pair(8)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006826 (Evidence)
Ensembl Gene Model ENSMUSG00000027871 (Evidence)
Entrez Gene 15492 (Evidence)
UniGene 140811
DFCI TC1578530, TC1756438
DoTS DT.101137856, DT.533971
NIA Mouse Gene Index U137516
EC 1.1.1.145, 5.3.3.1
Consensus CDS Project CCDS17670.1
International Mouse Phenotyping Consortium Status Hsd3b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006826 VEGA Gene Model | MGI Sequence Detail 7601 C57BL/6J ±  kb
transcript OTTMUST00000015760 VEGA | MGI Sequence Detail 1817 Not Applicable 
polypeptide OTTMUSP00000007240 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(115 from dbSNP Build 137)    SNPs within 2kb including multiple locations(143)
Protein-related
information
ResourceIDDescription
InterPro IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008785 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
References
(Earliest) J:29466 Bain PA, et al., Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8870-4
(Latest) J:218536 Wen Q, et al., Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis. Am J Physiol Endocrinol Metab. 2014 Dec 15;307(12):E1131-43
All references(64)
Other
accession IDs
MGD-MRK-10946, MGI:1196249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory