Hsd3b1
Gene Detail

Symbol Name ID

Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 MGI:96233

Synonyms

D3Ertd383e

Feature Type

protein coding gene

Genetic Map

Chromosome 3

42.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr3:98852194-98859794 bp, - strand From VEGA annotation of GRCm38   7601 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69149  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: bifunctional 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Gene Tree: Hsd3b1

Human homologs

Human Homolog		HSD3B2, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
NCBI Gene ID		3284
neXtProt AC		NX_P26439
Human Synonyms		HSD3B, HSDB, SDR11E2
Human Chr (Location)		1p13.1; chr1:119957554-119965662 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HSD3B2

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	metabolic process, steroid biosynthetic process
Component	endoplasmic reticulum, integral to membrane, ...
Function	3-beta-hydroxy-delta5-steroid dehydrogenase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (29 records)
Data Summary: Results (298)    Tissues (156)    Images (60)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	112
Western blot	24
RT-PCR	135

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) Genomic(2) cDNA(48) Primer pair(7)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006826 (Evidence)
Ensembl Gene Model	ENSMUSG00000027871 (Evidence)
Entrez Gene	15492 (Evidence)
UniGene	140811
DFCI	TC1578530, TC1756438
DoTS	DT.101137856, DT.533971
NIA Mouse Gene Index	U137516
EC	1.1.1.145, 5.3.3.1
Consensus CDS Project	CCDS17670.1
International Mouse Knockout Project Status	Hsd3b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006826	VEGA Gene Model | MGI Sequence Detail	7601	C57BL/6J
transcript	OTTMUST00000015760	VEGA | MGI Sequence Detail	1817	Not Applicable
polypeptide	OTTMUSP00000007240	VEGA | MGI Sequence Detail	367	Not Applicable

All sequences(34) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002225	3-beta hydroxysteroid dehydrogenase/isomerase
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000008785	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

References

(Earliest) J:29466 Bain PA, et al., Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8870-4
(Latest) J:192626 Miyado M, et al., Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012 Dec;153(12):6033-40
All references(63)

Other accession IDs

MGD-MRK-10946, MGI:1196249