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Hrc
Gene Detail
 Symbol
Name
ID
Hrc
histidine rich calcium binding protein
MGI:96226
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr7:45335290-45338973 bp, + strand
From VEGA annotation of GRCm38

  3684 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137234  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Gene Tree: Hrc

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired weight gain and weight loss around 1 year of age and increased susceptibility to induced cardiac hypertrophy.
 
Interactions
Hrc interacts with 25 markers (Mir24-1, Mir24-2, Mir128-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process calcium ion homeostasis, regulation of heart contraction
Component sarcoplasmic reticulum membrane
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (19)    Tissues (16)   
Theiler Stages: 11, 13, 17, 20, 22, 24, 26, 27, 28
Assay TypeResults
RT-PCR 19
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023829 (Evidence)
Ensembl Gene ModelENSMUSG00000038239 (Evidence)
Entrez Gene15464 (Evidence)
UniGene39968
DFCITC1585340
DoTSDT.487968, DT.91581278
NIA Mouse Gene IndexU008070
Consensus CDS ProjectCCDS39950.1
International Mouse Knockout Project StatusHrc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023829 VEGA Gene Model | MGI Sequence Detail 3684 C57BL/6J ±  kb
transcript OTTMUST00000058210 VEGA | MGI Sequence Detail 2410 Not Applicable 
polypeptide OTTMUSP00000028172 VEGA | MGI Sequence Detail 738 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019552 Histidine-rich calcium-binding
InterPro IPR015666 Histidine-rich calcium-binding protein
Protein Ontology PR:000008749 sarcoplasmic reticulum histidine-rich calcium-binding protein
References (Earliest) J:11193 Hofmann SL, et al., cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics. 1991 Apr;9(4):656-69
(Latest) J:126060 Arvanitis DA, et al., Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1581-9
All references(35)
Other
accession IDs
MGD-MRK-10933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory