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Hrc Gene Detail
Summary
  • Symbol
    Hrc
  • Name
    histidine rich calcium binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:96226
    NCBI Gene: 15464
  • Gene Overview
    MyGene.info: HRC
Location & Maps
more
  • Sequence Map
    Chr7:45335290-45338974 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3685 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.26 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    HRC, histidine rich calcium binding protein
  • Vertebrate Orthologs
    4
  • Human Ortholog
    HRC, histidine rich calcium binding protein
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 3270
    neXtProt AC: NX_P23327

  • Chr Location
    19q13.33; chr19:49151198-49155429 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired weight gain and weight loss around 1 year of age and increased susceptibility to induced cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023829 VEGA Gene Model | MGI Sequence Detail 3685 C57BL/6J ±  kb
transcript OTTMUST00000058210 VEGA | MGI Sequence Detail 2411 Not Applicable  
polypeptide OTTMUSP00000028172 VEGA | MGI Sequence Detail 738 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR019552 Histidine-rich calcium-binding
    IPR015666 Sarcoplasmic reticulum histidine-rich calcium-binding protein
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10933
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:11193 Hofmann SL, et al., cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics. 1991 Apr;9(4):656-69
  • Latest
    J:126060 Arvanitis DA, et al., Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1581-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory