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Lipc
Gene Detail
Symbol

Name
ID
Lipc
lipase, hepatic
MGI:96216
Synonyms
HL, Hpl
Feature Type
protein coding gene
Genetic Map
Chromosome 9
39.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr9:70798129-70934808 bp, - strand
From Ensembl annotation of GRCm38

  136680 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Lipc

Human
homologs
Human Homolog LIPC, lipase, hepatic
NCBI Gene ID 3990
neXtProt AC  NX_P11150
Human Synonyms  HDLCQ12, HL, HTGL, LIPH
Human Chr (Location)  15q21-q23; chr15:58410754-58568874 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human LIPC
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit elevated plasma total cholesterol, phospholipids, and high density lipoprotein cholesterol.
 
Interactions
Lipc interacts with 44 markers (Mir1b, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cholesterol homeostasis, cholesterol metabolic process, ...
Component cell surface, early endosome, ...
Function acylglycerol lipase activity, apolipoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (2)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
Northern blot 1
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(32) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032207 (Evidence)
Entrez Gene15450 (Evidence)
UniGene390187
DFCITC1582919, TC1751420
DoTSDT.491740, DT.94295920, DT.97344698
NIA Mouse Gene IndexU031061
EC3.1.1.3
Consensus CDS ProjectCCDS23324.1
International Mouse Knockout Project StatusLipc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032207 Ensembl Gene Model | MGI Sequence Detail 136680 C57BL/6J ±  kb
transcript ENSMUST00000034731 Ensembl | MGI Sequence Detail 1919 Not Applicable 
polypeptide ENSMUSP00000034731 Ensembl | MGI Sequence Detail 510 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(863 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002333 Hepatic lipase
InterPro IPR000734 Lipase
InterPro IPR008976 Lipase/lipooxygenase, PLAT/LH2
InterPro IPR013818 Lipase, N-terminal
InterPro IPR016272 Lipoprotein lipase, LIPH
InterPro IPR001024 Lipoxygenase, LH2
Protein Ontology PR:000009833 hepatic triacylglycerol lipase
References
(Earliest) J:19014 Komaromy MC, et al., Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1526-30
(Latest) J:207978 Bartelt A, et al., Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity. Bone. 2014 May;62:90-8
All references(89)
Other
accession IDs
MGD-MRK-10920, MGI:2142998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory