Lipc MGI Mouse Gene Detail - MGI:96216

Symbol

Lipc
Name

lipase C, hepatic type
Synonyms

HL, Hpl

Feature Type

protein coding gene
IDs

MGI:96216
NCBI Gene: 15450
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:70705410-70859503 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 39.57 cM
Mapping Data

13 experiments

SNPs within 2kb

4271 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96216	protein coding gene	Chr9:70705410-70859508 (-)
129S1/SvImJ	ENSMUSG00200042241	protein coding gene	Chr9:67808135-67956366 (-)
A/J	ENSMUSG00195024904	protein coding gene	Chr9:67583647-67737533 (-)
AKR/J	ENSMUSG00220036154	protein coding gene	Chr9:67717464-67875434 (-)
BALB/cJ	ENSMUSG00180014990	protein coding gene	Chr9:67697984-67851874 (-)
C3H/HeJ	ENSMUSG00175011488	protein coding gene	Chr9:67711357-67865225 (-)
C57BL/6NJ	ENSMUSG00215028376	protein coding gene	Chr9:67649305-67805927 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032408	protein coding gene	Chr9:67976321-68104543 (-)
CAST/EiJ	ENSTCUG00005026845	protein coding gene	Chr9:67531705-67680117 (-)
CBA/J	ENSMUSG00210014048	protein coding gene	Chr9:67792045-67945914 (-)
DBA/2J	ENSMUSG00185033588	protein coding gene	Chr9:67815794-67969656 (-)
FVB/NJ	ENSMUSG00205015812	protein coding gene	Chr9:68090042-68243940 (-)
JF1/MsJ	ENSUMUG00000013414	protein coding gene	Chr9:67870784-68024042 (-)
LP/J	ENSMUSG00230026113	protein coding gene	Chr9:68003274-68151503 (-)
NOD/ShiLtJ	ENSMUSG00190022309	protein coding gene	Chr9:67914469-68068332 (-)
NZO/HlLtJ	ENSMUSG00225045031	protein coding gene	Chr9:68121174-68268898 (-)
PWK/PhJ	ENSLUMG00010025931	protein coding gene	Chr9:67794019-67942149 (-)
SPRET/EiJ	ENSMSPG00010017084	protein coding gene	Chr9:68869524-69021208 (-)
WSB/EiJ	ENSIUOG00005022406	protein coding gene	Chr9:67280043-67427958 (-)

Human Ortholog

LIPC, lipase C, hepatic type

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIPC, lipase C, hepatic type
Synonyms

HDLCQ12, HL, HTGL
Links

HGNC:6619

NCBI Gene ID: 3990

UniProt: P11150
Chr Location

15q21.3; chr15:58410380-58570449 (+) GRCh38

MGI Vertebrate Homology

Lipc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LIPC
Protein SuperFamily

Lipoprotein_lipase_LIPH
Gene Tree

Lipc

Diseases

6 with human LIPC associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				familial combined hyperlipidemia IDs familial combined hyperlipidemia DOID:13809 ICD10CM:E78.49 MESH:D006950 NCI:C35637 OMIM:144250 UMLS_CUI:C0020474
				kidney disease IDs kidney disease DOID:557 EFO:0003086 ICD10CM:N08 ICD9CM:588.8 ICD9CM:588.89 MESH:D007674 NCI:C3149 UMLS_CUI:C0022658
				peripheral vascular disease IDs peripheral vascular disease DOID:341 DOID:2868 ICD9CM:443.81 MESH:D001157 UMLS_CUI:C0003838 UMLS_CUI:C0031115
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

2
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Lipc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit elevated plasma total cholesterol, phospholipids, and high density lipoprotein cholesterol.

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All GO Annotations

87
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

628
Tissues

10
cDNA Data

31
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lipc

ZFIN lipca

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All Sequences

64
RefSeq

18
UniProt

5
CCDS

CCDS23324.1, CCDS90617.1

Ensembl

ENSMUSG00000032207 (Evidence)
NCBI Gene

15450

			Length	Strain/Species	Flank
genomic	15450	NCBI Gene Model \| MGI Sequence Detail	154094	C57BL/6J	± kb
transcript	NM_008280	RefSeq \| MGI Sequence Detail	1934	FVB/N
polypeptide	P27656	UniProt \| EBI \| MGI Sequence Detail	510	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009833 hepatic triacylglycerol lipase

(term hierarchy)
EC

3.1.1.3, 3.1.1.32, 3.1.1.5
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR002333 Hepatic lipase

IPR013818 Lipase

IPR016272 Lipase, LIPH-type

IPR033906 Lipase, N-terminal

IPR001024 PLAT/LH2 domain

IPR036392 PLAT/LH2 domain superfamily

IPR000734 Triacylglycerol lipase family
GlyGen

P27656 2 sites

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All nucleic 38

Genomic 1

cDNA 33

Primer pair 2

Other 2

Microarray probesets 4

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MGD-MRK-10920, MGI:2142998

Summaries

All 110

Developmental Gene Expression 7

Gene Ontology 14

Phenotypes 42
Earliest

J:20061 Blomberg B, et al., DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes. Proc Natl Acad Sci U S A. 1982 Jan;79(2):530-3
Latest

J:338938 Kobayashi K, et al., Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15 axis is essential for fetal growth. Life Sci Alliance. 2023 Oct;6(10)

TSS for Lipc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90428	Chr9:70859426-70859437 (-)	71 bp
Tssr90427	Chr9:70842090-70842129 (-)	17,393 bp
Tssr90426	Chr9:70841880-70841906 (-)	17,610 bp
Tssr90425	Chr9:70841862-70841867 (-)	17,638 bp
Tssr90424	Chr9:70742462-70742466 (-)	117,039 bp
Tssr90423	Chr9:70724261-70724276 (-)	135,234 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24