Lipc
Gene Detail

Symbol Name ID

Lipc lipase, hepatic MGI:96216

Synonyms

HL, Hpl

Feature Type

protein coding gene

Genetic Map

Chromosome 9

39.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr9:70798129-70934808 bp, - strand From Ensembl annotation of GRCm38   136680 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Lipc

Human homologs

Human Homolog		LIPC, lipase, hepatic
NCBI Gene ID		3990
neXtProt AC		NX_P11150
Human Synonyms		HDLCQ12, HL, HTGL, LIPH
Human Chr (Location)		15q21-q23; chr15:58724175-58861073 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LIPC

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygotes for a targeted null mutation exhibit elevated plasma total cholesterol, phospholipids, and high density lipoprotein cholesterol.

 

Gene Ontology (GO) classifications

All GO classifications: (57 annotations)

Process	cholesterol homeostasis, cholesterol metabolic process, ...
Component	cell surface, early endosome, ...
Function	acylglycerol lipase activity, apolipoprotein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (2)    Images (21)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	21
Northern blot	1

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(32) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032207 (Evidence)
Entrez Gene	15450 (Evidence)
UniGene	390187
DFCI	TC1582919, TC1751420
DoTS	DT.491740, DT.94295920, DT.97344698
NIA Mouse Gene Index	U031061
EC	3.1.1.3
Consensus CDS Project	CCDS23324.1
International Mouse Knockout Project Status	Lipc

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032207	Ensembl Gene Model | MGI Sequence Detail	136680	C57BL/6J
transcript	ENSMUST00000034731	Ensembl | MGI Sequence Detail	1919	Not Applicable
polypeptide	ENSMUSP00000034731	Ensembl | MGI Sequence Detail	510	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(768 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002333	Hepatic lipase
InterPro	IPR000734	Lipase
InterPro	IPR008976	Lipase/lipooxygenase, PLAT/LH2
InterPro	IPR013818	Lipase, N-terminal
InterPro	IPR016272	Lipoprotein lipase, LIPH
InterPro	IPR001024	Lipoxygenase, LH2
Protein Ontology	PR:000009833	hepatic triacylglycerol lipase

References

(Earliest) J:19014 Komaromy MC, et al., Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1526-30
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(87)

Other accession IDs

MGD-MRK-10920, MGI:2142998