Hpd
Gene Detail

Symbol Name ID

Hpd 4-hydroxyphenylpyruvic acid dioxygenase MGI:96213

Synonyms

Flp, Hppd, Laf

Feature Type

protein coding gene

Genetic Map

Chromosome 5

62.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr5:123171807-123182725 bp, - strand From VEGA annotation of GRCm38   10919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: HPP_dOase
Gene Tree: Hpd

Human homologs

Human Homolog		HPD, 4-hydroxyphenylpyruvate dioxygenase
NCBI Gene ID		3242
neXtProt AC		NX_P32754
Human Synonyms		4HPPD, 4-HPPD, GLOD3, HPPDASE, PPD
Human Chr (Location)		12q24-qter; chr12:122277433-122326517 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HPD

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(2) Spontaneous(1)
 

CBA, C3H, DBA/2, SM and AKR have the F.1 form of this soluble liver antigen; A/J, A2G, BALB/c and C57BL/10 the F.2 form. F.2 antigen induces precipitating antibodies in F.1 but not F.2 strains and vice versa. F antigen immune response requires H2 Kk or Ak alleles.

 
Human Diseases Modeled Using Mouse Hpd (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	aromatic amino acid family metabolic process, L-phenylalanine catabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	4-hydroxyphenylpyruvate dioxygenase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (96)    Images (25)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	117

cDNA source data(192)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(194) Genomic(1) cDNA(192) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026899 (Evidence)
Ensembl Gene Model	ENSMUSG00000029445 (Evidence)
Entrez Gene	15445 (Evidence)
UniGene	439709
DFCI	TC1575643
DoTS	DT.494529
NIA Mouse Gene Index	U026709
EC	1.13.11.24, 1.13.11.27
Consensus CDS Project	CCDS39265.1
International Mouse Knockout Project Status	Hpd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026899	VEGA Gene Model | MGI Sequence Detail	10919	C57BL/6J
transcript	OTTMUST00000066520	VEGA | MGI Sequence Detail	1402	Not Applicable
polypeptide	OTTMUSP00000033345	VEGA | MGI Sequence Detail	393	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005956	4-hydroxyphenylpyruvate dioxygenase
InterPro	IPR004360	Glyoxalase/fosfomycin resistance/dioxygenase domain
Protein Ontology	PR:000008730	4-hydroxyphenylpyruvate dioxygenase

References

(Earliest) J:5062 Fravi G, et al., Induction by allogeneic extracts of liver-specific precipitating autoantibodies in the mouse. Nature. 1968 Apr 13;218(137):141-3
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(62)

Other accession IDs

MGD-MRK-10914, MGD-MRK-10921, MGD-MRK-11728, MGD-MRK-9821, MGD-MRK-9831, MGI:95551