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Hpd
Gene Detail
Symbol

Name
ID
Hpd
4-hydroxyphenylpyruvic acid dioxygenase
MGI:96213
Synonyms
Flp, Hppd, Laf
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:123171807-123182725 bp, - strand
From VEGA annotation of GRCm38

  10919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HPD
Protein SuperFamily: HPP_dOase
Gene Tree: Hpd

Human
homologs
HPD, 4-hydroxyphenylpyruvate dioxygenase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3242
neXtProt AC: NX_P32754

Human Synonyms: 4HPPD, 4-HPPD, GLOD3, HPPDASE, PPD

Human Chr (Location): 12q24.31; chr12:121839527-121888611 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HPD

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
CBA, C3H, DBA/2, SM and AKR have the F.1 form of this soluble liver antigen; A/J, A2G, BALB/c and C57BL/10 the F.2 form. F.2 antigen induces precipitating antibodies in F.1 but not F.2 strains and vice versa. F antigen immune response requires H2 Kk or Ak alleles.
 
Human Diseases Modeled in Mice Using Hpd (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hpd interacts with 33 markers (Mir25, Mir143, Mir149, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (96)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(192)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hpd    NEW 
Molecular
reagents
All nucleic(194) Genomic(1) cDNA(192) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026899 (Evidence)
Ensembl Gene Model ENSMUSG00000029445 (Evidence)
Entrez Gene 15445 (Evidence)
UniGene 439709
DFCI TC1575643
DoTS DT.494529
NIA Mouse Gene Index U026709
EC 1.13.11.24, 1.13.11.27
Consensus CDS Project CCDS39265.1
International Mouse Phenotyping Consortium Status Hpd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026899 VEGA Gene Model | MGI Sequence Detail 10919 C57BL/6J ±  kb
transcript OTTMUST00000066520 VEGA | MGI Sequence Detail 1402 Not Applicable 
polypeptide OTTMUSP00000033345 VEGA | MGI Sequence Detail 393 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005956 4-hydroxyphenylpyruvate dioxygenase
InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
Protein Ontology PR:000008730 4-hydroxyphenylpyruvate dioxygenase
References
(Earliest) J:5062 Fravi G, et al., Induction by allogeneic extracts of liver-specific precipitating autoantibodies in the mouse. Nature. 1968 Apr 13;218(137):141-3
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(56)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10914, MGD-MRK-10921, MGD-MRK-11728, MGD-MRK-9821, MGD-MRK-9831, MGI:95551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory