About   Help   FAQ
Hpd Gene Detail
Summary
  • Symbol
    Hpd
  • Name
    4-hydroxyphenylpyruvic acid dioxygenase
  • Synonyms
    Flp, Hppd, Laf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96213
    NCBI Gene: 15445
Location & Maps
more
  • Sequence Map
    Chr5:123171807-123182727 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10921 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HPD, 4-hydroxyphenylpyruvate dioxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HPD, 4-hydroxyphenylpyruvate dioxygenase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    4HPPD, 4-HPPD, GLOD3, HPPDASE, PPD
  • Links
    NCBI Gene ID: 3242
    neXtProt AC: NX_P32754

  • Chr Location
    12q24.31; chr12:121839527-121888611 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1620
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HPD
  • Protein SuperFamily
  • Gene Tree
    Hpd
Human Diseases
more
  • Diseases
    1 with Hpd mouse models; 2 with human HPD associations

Human Disease Mouse Models
       Tyrosinemia, Type III; TYRSN3   OMIM: 276710 View 1 model
       Hawkinsinuria   OMIM: 140350
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Hpd
  • Incidental Mutations
CBA, C3H, DBA/2, SM and AKR have the F.1 form of this soluble liver antigen; A/J, A2G, BALB/c and C57BL/10 the F.2 form. F.2 antigen induces precipitating antibodies in F.1 but not F.2 strains and vice versa. F antigen immune response requires H2 Kk or Ak alleles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026899 VEGA Gene Model | MGI Sequence Detail 10921 C57BL/6J ±  kb
transcript OTTMUST00000066520 VEGA | MGI Sequence Detail 1404 Not Applicable  
polypeptide OTTMUSP00000033345 VEGA | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    60 from dbSNP Build 137
  • PCR
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008730 4-hydroxyphenylpyruvate dioxygenase
  • EC
  • InterPro Domains
    IPR005956 4-hydroxyphenylpyruvate dioxygenase
    IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
    IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
Molecular
Reagents
less
  • All nucleic 194
    Genomic 1
    cDNA 192
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10914, MGD-MRK-10921, MGD-MRK-11728, MGD-MRK-9821, MGD-MRK-9831, MGI:95551
References
more
  • Summaries
    All 54
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:5062 Fravi G, et al., Induction by allogeneic extracts of liver-specific precipitating autoantibodies in the mouse. Nature. 1968 Apr 13;218(137):141-3
  • Latest
    J:225652 Harten SK, et al., The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. BMC Biol. 2015;13:21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory