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Hpd Gene Detail
Summary
  • Symbol
    Hpd
  • Name
    4-hydroxyphenylpyruvic acid dioxygenase
  • Synonyms
    Flp, Hppd, Laf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96213
    NCBI Gene: 15445
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123171807-123182686 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.82 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96213
protein coding gene Chr5:123171807-123182727 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030067
protein coding gene Chr5:126860775-126871691 (-)
A/J MGP_AJ_G0030032
protein coding gene Chr5:121605310-121616224 (-)
AKR/J MGP_AKRJ_G0029968
protein coding gene Chr5:125522680-125533619 (-)
BALB/cJ MGP_BALBcJ_G0030043
protein coding gene Chr5:122939807-122950699 (-)
C3H/HeJ MGP_C3HHeJ_G0029760
protein coding gene Chr5:126147582-126160498 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030496
protein coding gene Chr5:131753110-131763989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027722
protein coding gene Chr5:116187979-116199166 (-)
CAST/EiJ MGP_CASTEiJ_G0029169
protein coding gene Chr5:125253816-125264797 (-)
CBA/J MGP_CBAJ_G0029730
protein coding gene Chr5:136924506-136939134 (-)
DBA/2J MGP_DBA2J_G0029880
protein coding gene Chr5:121651539-121662829 (-)
FVB/NJ MGP_FVBNJ_G0029836
protein coding gene Chr5:120653474-120664851 (-)
LP/J MGP_LPJ_G0029969
protein coding gene Chr5:127395678-127406584 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029867
protein coding gene Chr5:140599448-140611204 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030537
protein coding gene Chr5:125126200-125137119 (-)
PWK/PhJ MGP_PWKPhJ_G0028883
protein coding gene Chr5:120440080-120451717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028720
protein coding gene Chr5:122813271-122827163 (-)
WSB/EiJ MGP_WSBEiJ_G0029244
protein coding gene Chr5:125788833-125800576 (-)



Homology
more
  • Human Ortholog
    HPD, 4-hydroxyphenylpyruvate dioxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HPD, 4-hydroxyphenylpyruvate dioxygenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    4HPPD, 4-HPPD, GLOD3, HPPDASE, PPD
  • Links
    NCBI Gene ID: 3242
    neXtProt AC: NX_P32754
    UniProt: P32754

  • Chr Location
    12q24.31; chr12:121839527-121888611 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1620
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HPD
  • Protein SuperFamily
  • Gene Tree
    Hpd
Human Diseases
more
  • Diseases
    1 with Hpd mouse models; 1 with human HPD associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
CBA, C3H, DBA/2, SM and AKR have the F.1 form of this soluble liver antigen; A/J, A2G, BALB/c and C57BL/10 the F.2 form. F.2 antigen induces precipitating antibodies in F.1 but not F.2 strains and vice versa. F antigen immune response requires H2 Kk or Ak alleles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15445 NCBI Gene Model | MGI Sequence Detail 10880 C57BL/6J ±  kb
    transcript NM_008277 RefSeq | MGI Sequence Detail 1400 C57BL/6  
    polypeptide P49429 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 196
      Genomic 1
      cDNA 193
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10914, MGD-MRK-10921, MGD-MRK-11728, MGD-MRK-9821, MGD-MRK-9831, MGI:95551
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:5062 Fravi G, et al., Induction by allogeneic extracts of liver-specific precipitating autoantibodies in the mouse. Nature. 1968 Apr 13;218(137):141-3
    • Latest
      J:241908 Pankowicz FP, et al., Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. Nat Commun. 2016 Aug 30;7:12642

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory