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Hoxd3 Gene Detail
Summary
  • Symbol
    Hoxd3
  • Name
    homeobox D3
  • Synonyms
    Hox-4.1, Hox-5.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96207
    NCBI Gene: 15434
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD3
Location & Maps
more
  • Sequence Map
    Chr2:74711927-74748442 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36516 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HOXD3, homeobox D3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXD3, homeobox D3
    Orthology source: HomoloGene
  • Synonyms
    HOX1D, HOX4, Hox-4.1, HOX4A
  • Links
    NCBI Gene ID: 3232
    neXtProt AC: NX_P31249

  • Chr Location
    2q31.1; chr2:176136921-176173102 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    19
  • Genomic Mutations
    16 involving Hoxd3
  • Incidental Mutations
Mice homozygous for a knock-out allele show partial postnatal lethality, asymmetric rib-sternum attachment, and anterior transformations of the cervical vertebrae I (atlas) and II (axis). Mice homozygous for a different knock-out allele lack the anteriorarch of the atlas and the dens of the axis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045589 VEGA Gene Model | MGI Sequence Detail 36516 C57BL/6J ±  kb
transcript OTTMUST00000040120 VEGA | MGI Sequence Detail 2968 Not Applicable  
polypeptide OTTMUSP00000017900 VEGA | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    74 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 30
    Genomic 10
    cDNA 15
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10848, MGD-MRK-10862, MGD-MRK-10908
References
more
  • Summaries
    All 79
    Developmental Gene Expression 44
    Gene Ontology 8
    Phenotypes 41
  • Earliest
    J:10249 Pravtcheva D, et al., Chromosome assignment of the murine Hox-4.1 gene. Genomics. 1989 Oct;5(3):541-5
  • Latest
    J:217502 Chojnowski JL, et al., Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory