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Hoxd3
Gene Detail
Symbol

Name
ID
Member of
Hoxd3
homeobox D3
MGI:96207
Hoxd cluster
Synonyms
Hox-4.1, Hox-5.5
Feature Type
protein coding gene
Genetic Map
Chromosome 2
44.13 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:74711927-74748442 bp, + strand
From VEGA annotation of GRCm38

  36516 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Hoxd3

Human
homologs
Human Homolog HOXD3, homeobox D3
NCBI Gene ID 3232
neXtProt AC  NX_P31249
Human Synonyms  HOX1D, HOX4, Hox-4.1, HOX4A
Human Chr (Location)  2q31.1; chr2:176136999-176173101 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Genomic Mutations involving Hoxd3 (13)
 
Mice homozygous for a knock-out allele show partial postnatal lethality, asymmetric rib-sternum attachment, and anterior transformations of the cervical vertebrae I (atlas) and II (axis). Mice homozygous for a different knock-out allele lack the anterior arch of the atlas and the dens of the axis.
 
Interactions
Hoxd3 interacts with 272 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process anterior/posterior pattern specification, cartilage development, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (291)    Tissues (143)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 235
Northern blot 1
RT-PCR 55
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(10) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000045589 (Evidence)
Ensembl Gene ModelENSMUSG00000079277 (Evidence)
Entrez Gene15434 (Evidence)
UniGene430708
DFCITC1592361, TC1649430
Consensus CDS ProjectCCDS38149.1
International Mouse Knockout Project StatusHoxd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045589 VEGA Gene Model | MGI Sequence Detail 36516 C57BL/6J ±  kb
transcript OTTMUST00000040123 VEGA | MGI Sequence Detail 2413 Not Applicable 
polypeptide OTTMUSP00000017902 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008721 homeobox protein Hox-D3
References
(Earliest) J:10249 Pravtcheva D, et al., Chromosome assignment of the murine Hox-4.1 gene. Genomics. 1989 Oct;5(3):541-5
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(76)
Other
accession IDs
MGD-MRK-10848, MGD-MRK-10862, MGD-MRK-10908

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory