Hoxd3
Gene Detail

Symbol Name ID

Hoxd3 homeobox D3 MGI:96207

Synonyms

Hox-4.1, Hox-5.5

Feature Type

protein coding gene

Genetic Map

Chromosome 2

44.13 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr2:74711929-74748274 bp, + strand From VEGA annotation of GRCm38   36346 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Hoxd3

Human homologs

Human Homolog		HOXD3, homeobox D3
NCBI Gene ID		3232
neXtProt AC		NX_P31249
Human Synonyms		HOX1D, HOX4, Hox-4.1, HOX4A
Human Chr (Location)		2q31.1; chr2:177028805-177037826 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele show partial postnatal lethality, asymmetric rib-sternum attachment, and anterior transformations of the cervical vertebrae I (atlas) and II (axis). Mice homozygous for a different knock-out allele lack the anterior arch of the atlas and the dens of the axis.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	anterior/posterior pattern specification, cartilage development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (39 records)
Data Summary: Results (288)    Tissues (135)    Images (33)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	232
Northern blot	1
RT-PCR	55

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(10) cDNA(16) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019164 (Evidence)
Ensembl Gene Model	ENSMUSG00000079277 (Evidence)
Entrez Gene	15434 (Evidence)
UniGene	430708
DFCI	TC1592361, TC1649430
Consensus CDS Project	CCDS38149.1
International Mouse Knockout Project Status	Hoxd3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019164	VEGA Gene Model | MGI Sequence Detail	36346	C57BL/6J
transcript	OTTMUST00000040120	VEGA | MGI Sequence Detail	2969	Not Applicable
polypeptide	OTTMUSP00000017900	VEGA | MGI Sequence Detail	433	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025281	Domain of unknown function DUF4074
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008721	homeobox protein Hox-D3

References

(Earliest) J:10249 Pravtcheva D, et al., Chromosome assignment of the murine Hox-4.1 gene. Genomics. 1989 Oct;5(3):541-5
(Latest) J:182758 Tschopp P, et al., Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters. Development. 2012 Mar;139(5):929-39
All references(77)

Other accession IDs

MGD-MRK-10848, MGD-MRK-10862, MGD-MRK-10908