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Hoxd3 Gene Detail
Summary
  • Symbol
    Hoxd3
  • Name
    homeobox D3
  • Synonyms
    Hox-4.1, Hox-5.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96207
    NCBI Gene: 15434
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:74711927-74748442 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36516 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM, cytoband C2
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    HOXD3, homeobox D3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXD3, homeobox D3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HOX1D, HOX4, Hox-4.1, HOX4A
  • Links
    NCBI Gene ID: 3232
    neXtProt AC: NX_P31249
    UniProt: P31249

  • Chr Location
    2q31.1; chr2:176136921-176173102 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show partial postnatal lethality, asymmetric rib-sternum attachment, and anterior transformations of the cervical vertebrae I (atlas) and II (axis). Mice homozygous for a different knock-out allele lack the anteriorarch of the atlas and the dens of the axis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000045589 VEGA Gene Model | MGI Sequence Detail 36516 C57BL/6J ±  kb
    transcript OTTMUST00000040120 VEGA | MGI Sequence Detail 2968 Not Applicable  
    polypeptide OTTMUSP00000017900 VEGA | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      74 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 10
      cDNA 16
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10848, MGD-MRK-10862, MGD-MRK-10908
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 49
      Gene Ontology 9
      Phenotypes 43
    • Earliest
      J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
    • Latest
      J:259687 Zakany J, et al., Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo. BMC Res Notes. 2018 Mar 27;11(1):193

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory