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Hoxd13
Gene Detail
 Symbol
Name
ID
Member of
Hoxd13
homeobox D13
MGI:96205
Hoxd cluster
Synonyms Hox-4.8, spdh
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:74668310-74671599 bp, + strand
From VEGA annotation of GRCm38

  3290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

Gene Tree: Hoxd13

Human
homologs
Human Homolog HOXD13, homeobox D13
NCBI Gene ID 3239
neXtProt AC  NX_P35453
Human Synonyms  BDE, BDSD, HOX4I, SPD
Human Chr (Location)  2q31.1; chr2:176092804-176095938 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human HOXD13
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Spontaneous(2) Targeted(32)
Genomic Mutations involving Hoxd13 (19)
Incidental mutations (data from APF )
 
Homozygotes for targeted and spontaneous mutations exhibit abnormalities of the axial skeleton, especially limbs, and of the male accessory organs, and agenesis of the preputial glands. Mutant males are sterile.
 
Human Diseases Modeled Using Mouse Hoxd13 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Hoxd13 interacts with 213 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process anterior/posterior pattern specification, branch elongation of an epithelium, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (180 records)
Data Summary: Results (391)    Tissues (171)    Images (165)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 28
RNA in situ 303
RT-PCR 60
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(7) cDNA(17) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013304 (Evidence)
Ensembl Gene ModelENSMUSG00000001819 (Evidence)
Entrez Gene15433 (Evidence)
UniGene57227
DFCITC1599500, TC1616679
DoTSDT.87049031, DT.91327573
NIA Mouse Gene IndexU001927
Consensus CDS ProjectCCDS16139.1
International Mouse Knockout Project StatusHoxd13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013304 VEGA Gene Model | MGI Sequence Detail 3290 C57BL/6J ±  kb
transcript OTTMUST00000032142 VEGA | MGI Sequence Detail 2483 Not Applicable 
polypeptide OTTMUSP00000014292 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR022067 Homeobox protein Hox1A3 N-terminal
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008720 homeobox protein Hox-D13
References (Earliest) J:9650 Ryder K, et al., jun-D: a third member of the jun gene family. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1500-3
(Latest) J:207496 Symmons O, et al., Functional and topological characteristics of mammalian regulatory domains. Genome Res. 2014 Mar;24(3):390-400
All references(232)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-10855, MGD-MRK-10906

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory