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Hoxd13
Gene Detail
Symbol

Name
ID
Member of
Hoxd13
homeobox D13
MGI:96205
Hoxd cluster
Synonyms
Hox-4.8, spdh
Feature Type
protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:74668310-74671599 bp, + strand
From VEGA annotation of GRCm38

  3290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: HOXD13
Gene Tree: Hoxd13

Human
homologs
HOXD13, homeobox D13
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3239
neXtProt AC: NX_P35453

Human Synonyms: BDE, BDSD, HOX4I, SPD

Human Chr (Location): 2q31.1; chr2:176087505-176095938 (+)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human HOXD13

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Spontaneous(3) Targeted(33) Transgenic(2)
Genomic Mutations involving Hoxd13 (25)
Incidental mutations (data from APF )
 
Homozygotes for targeted and spontaneous mutations exhibit abnormalities of the axial skeleton, especially limbs, and of the male accessory organs, and agenesis of the preputial glands. Mutant males are sterile.
 
Human Diseases Modeled in Mice Using Hoxd13 (1)    Mutations Annotated to Human Diseases (5)    Phenotype Images(1)
Interactions
Hoxd13 interacts with 213 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anterior/posterior pattern specification, branch elongation of an epithelium, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (193 records)
Data Summary: Results (422)    Tissues (179)    Images (188)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 334
RT-PCR 60
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXD13 ; Xenbase hoxd13 ; ZFIN hoxd13a    NEW 
Molecular
reagents
All nucleic(31) Genomic(7) cDNA(17) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000013304 (Evidence)
Ensembl Gene Model ENSMUSG00000001819 (Evidence)
Entrez Gene 15433 (Evidence)
UniGene 57227
DFCI TC1599500, TC1616679
DoTS DT.87049031, DT.91327573
NIA Mouse Gene Index U001927
Consensus CDS Project CCDS16139.1
International Mouse Phenotyping Consortium Status Hoxd13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013304 VEGA Gene Model | MGI Sequence Detail 3290 C57BL/6J ±  kb
transcript OTTMUST00000032142 VEGA | MGI Sequence Detail 2483 Not Applicable 
polypeptide OTTMUSP00000014292 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR022067 Homeobox protein Hox1A3 N-terminal
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008720 homeobox protein Hox-D13
References
(Earliest) J:9650 Ryder K, et al., jun-D: a third member of the jun gene family. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1500-3
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(243)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-10855, MGD-MRK-10906

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory