Hoxd13
Gene Detail

Symbol Name ID

Hoxd13 homeobox D13 MGI:96205

Synonyms

Hox-4.8, spdh

Feature Type

protein coding gene

Genetic Map

Chromosome 2

44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:74668310-74671599 bp, + strand From VEGA annotation of GRCm38   3290 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken

Gene Tree: Hoxd13

Human homologs

Human Homolog		HOXD13, homeobox D13
NCBI Gene ID		3239
neXtProt AC		NX_P35453
Human Synonyms		BDE, BDSD, HOX4I, SPD
Human Chr (Location)		2q31.1; chr2:176957532-176960666 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human HOXD13

Alleles and phenotypes

All alleles(15) : Targeted(13) Spontaneous(2)
 

Homozygotes for targeted and spontaneous mutations exhibit abnormalities of the axial skeleton, especially limbs, and of the male accessory organs, and agenesis of the preputial glands. Mutant males are sterile.

 
Human Diseases Modeled Using Mouse Hoxd13 (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	anterior/posterior pattern specification, branch elongation of an epithelium, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (171 records)
Data Summary: Results (354)    Tissues (165)    Images (135)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	28
RNA in situ	266
RT-PCR	60

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(7) cDNA(16) Primer pair(6) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000013304 (Evidence)
Ensembl Gene Model	ENSMUSG00000001819 (Evidence)
Entrez Gene	15433 (Evidence)
UniGene	57227
DFCI	TC1599500, TC1616679
DoTS	DT.87049031, DT.91327573
NIA Mouse Gene Index	U001927
Consensus CDS Project	CCDS16139.1
International Mouse Knockout Project Status	Hoxd13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013304	VEGA Gene Model | MGI Sequence Detail	3290	C57BL/6J
transcript	OTTMUST00000032142	VEGA | MGI Sequence Detail	2483	Not Applicable
polypeptide	OTTMUSP00000014292	VEGA | MGI Sequence Detail	339	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR022067	Homeobox protein Hox1A3 N-terminal
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000008720	homeobox protein Hox-D13

References

(Earliest) J:9650 Ryder K, et al., jun-D: a third member of the jun gene family. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1500-3
(Latest) J:192248 Montavon T, et al., Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20204-11
All references(222)

Other accession IDs

MGD-MRK-10855, MGD-MRK-10906