Hoxd12
Gene Detail

Symbol Name ID

Hoxd12 homeobox D12 MGI:96204

Synonyms

Hox-4.7, Hox-5.6

Feature Type

protein coding gene

Genetic Map

Chromosome 2

44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:74674929-74677706 bp, + strand From VEGA annotation of GRCm38   2778 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxd12

Human homologs

Human Homolog		HOXD12, homeobox D12
NCBI Gene ID		3238
neXtProt AC		NX_P35452
Human Synonyms		HOX4H
Human Chr (Location)		2q31.1; chr2:176964530-176965488 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for targeted null mutations exhibit minor forelimb defects affecting carpals, metacarpals, and phalanges, and alterations of smooth muscle layers of the rectum resulting in malformation of the internal anal sphincter.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	embryonic digit morphogenesis, multicellular organismal development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (102 records)
Data Summary: Results (330)    Tissues (222)    Images (82)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	295
RT-PCR	35

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(9) cDNA(11) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016555 (Evidence)
Ensembl Gene Model	ENSMUSG00000001823 (Evidence)
Entrez Gene	15432 (Evidence)
UniGene	57124
DFCI	TC1589597
DoTS	DT.101357132, DT.55161354
NIA Mouse Gene Index	U001928
Consensus CDS Project	CCDS38147.1
International Mouse Knockout Project Status	Hoxd12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016555	VEGA Gene Model | MGI Sequence Detail	2778	C57BL/6J
transcript	OTTMUST00000040008	VEGA | MGI Sequence Detail	2619	Not Applicable
polypeptide	OTTMUSP00000017846	VEGA | MGI Sequence Detail	268	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008719	homeobox protein Hox-D12

References

(Earliest) J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
(Latest) J:192010 Sheth R, et al., Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism. Science. 2012 Dec 14;338(6113):1476-80
All references(139)

Other accession IDs

MGD-MRK-10854, MGD-MRK-10863, MGD-MRK-10905