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Hoxd12
Gene Detail
 Symbol
Name
ID
Member of
Hoxd12
homeobox D12
MGI:96204
Hoxd cluster
Synonyms Hox-4.7, Hox-5.6
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:74675013-74677705 bp, + strand
From VEGA annotation of GRCm38

  2693 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxd12

Human
homologs
Human Homolog HOXD12, homeobox D12
NCBI Gene ID 3238
neXtProt AC  NX_P35452
Human Synonyms  HOX4H
Human Chr (Location)  2q31.1; chr2:176099802-176100760 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Chemically induced (ENU)(1) Targeted(25)
Genomic Mutations involving Hoxd12 (22)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit minor forelimb defects affecting carpals, metacarpals, and phalanges, and alterations of smooth muscle layers of the rectum resulting in malformation of the internal anal sphincter.
 
Interactions
Hoxd12 interacts with 219 markers (Mir1a-1, Mir1a-2, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process embryonic digit morphogenesis, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (109 records)
Data Summary: Results (357)    Tissues (228)    Images (99)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 322
RT-PCR 35
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(9) cDNA(11) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016555 (Evidence)
Ensembl Gene ModelENSMUSG00000001823 (Evidence)
Entrez Gene15432 (Evidence)
UniGene57124
DFCITC1589597
DoTSDT.101357132, DT.55161354
NIA Mouse Gene IndexU001928
Consensus CDS ProjectCCDS38147.1
International Mouse Knockout Project StatusHoxd12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016555 VEGA Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
transcript OTTMUST00000040008 VEGA | MGI Sequence Detail 2534 Not Applicable 
polypeptide OTTMUSP00000017846 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008719 homeobox protein Hox-D12
References (Earliest) J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
(Latest) J:208432 Schwarz D, et al., Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77
All references(146)
Other
accession IDs
MGD-MRK-10854, MGD-MRK-10863, MGD-MRK-10905

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory