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Hoxd12
Gene Detail
Symbol

Name
ID
Member of
Hoxd12
homeobox D12
MGI:96204
Hoxd cluster
Synonyms
Hox-4.7, Hox-5.6
Feature Type
protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:74675013-74677705 bp, + strand
From VEGA annotation of GRCm38

  2693 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: HOXD12
Gene Tree: Hoxd12

Human
homologs
HOXD12, homeobox D12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3238
neXtProt AC: NX_P35452

Human Synonyms: HOX4H

Human Chr (Location): 2q31.1; chr2:176098513-176103770 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(27)
Genomic Mutations involving Hoxd12 (26)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit minor forelimb defects affecting carpals, metacarpals, and phalanges, and alterations of smooth muscle layers of the rectum resulting in malformation of the internal anal sphincter.
 
Phenotype Images(1)
Interactions
Hoxd12 interacts with 218 markers (Mir1a-1, Mir1a-2, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process embryonic digit morphogenesis, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (112 records)
Data Summary: Results (357)    Tissues (228)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 322
RT-PCR 35
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXD12 ZFIN hoxd12a    NEW 
Molecular
reagents
All nucleic(26) Genomic(9) cDNA(11) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016555 (Evidence)
Ensembl Gene Model ENSMUSG00000001823 (Evidence)
Entrez Gene 15432 (Evidence)
UniGene 57124
DFCI TC1589597
DoTS DT.101357132, DT.55161354
NIA Mouse Gene Index U001928
Consensus CDS Project CCDS38147.1
International Mouse Phenotyping Consortium Status Hoxd12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016555 VEGA Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
transcript OTTMUST00000040008 VEGA | MGI Sequence Detail 2534 Not Applicable 
polypeptide OTTMUSP00000017846 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008719 homeobox protein Hox-D12
References
(Earliest) J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
(Latest) J:219584 Zhulyn O, et al., Sufu and Kif7 in limb patterning and development. Dev Dyn. 2015 Mar;244(3):468-78
All references(148)
Other
accession IDs
MGD-MRK-10854, MGD-MRK-10863, MGD-MRK-10905

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory