About   Help   FAQ
Hoxd12 Gene Detail
Summary
  • Symbol
    Hoxd12
  • Name
    homeobox D12
  • Synonyms
    Hox-4.7, Hox-5.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96204
    NCBI Gene: 15432
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD12
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:74675013-74677705 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2693 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HOXD12, homeobox D12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXD12, homeobox D12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX4H
  • Links
    NCBI Gene ID: 3238
    neXtProt AC: NX_P35452
    UniProt: P35452

  • Chr Location
    2q31.1; chr2:176099802-176100760 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit minor forelimb defects affecting carpals, metacarpals, and phalanges, and alterations of smooth muscle layers of the rectum resulting in malformation of the internal anal sphincter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016555 VEGA Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
    transcript OTTMUST00000040008 VEGA | MGI Sequence Detail 2534 Not Applicable  
    polypeptide OTTMUSP00000017846 VEGA | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      24 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 9
      cDNA 11
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10854, MGD-MRK-10863, MGD-MRK-10905
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 123
      Gene Ontology 6
      Phenotypes 65
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory