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Hoxd11
Gene Detail
Symbol

Name
ID
Member of
Hoxd11
homeobox D11
MGI:96203
Hoxd cluster
STS
Synonyms
E230017H14Rik, Hox-4.6, Hox-5.4, Hox-5.5
Feature Type
protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr2:74679557-74687016 bp, + strand
From VEGA annotation of GRCm38

  7460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7368  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXD11
Gene Tree: Hoxd11

Human
homologs
HOXD11, homeobox D11
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3237
neXtProt AC: NX_P31277

Human Synonyms: HOX4, HOX4F

Human Chr (Location): 2q31.1; chr2:176107356-176109588 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Spontaneous(1) Targeted(40) Transgenic(1)
Genomic Mutations involving Hoxd11 (33)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit homeotic transformations of sacral vertebrae, malformations of distal limbs, and reduced fertility in males.
 
Phenotype Images(5)
Interactions
Hoxd11 interacts with 81 markers (Mir27a, Mir27b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (145 records)
Data Summary: Results (429)    Tissues (237)    Images (119)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 386
RT-PCR 43
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase hoxd11 ; ZFIN hoxd11a    NEW 
Molecular
reagents
All nucleic(34) Genomic(11) cDNA(15) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016551 (Evidence)
Ensembl Gene Model ENSMUSG00000042499 (Evidence)
Entrez Gene 15431 (Evidence)
UniGene 207763
DFCI TC1599639, TC1624899
DoTS DT.91430338, DT.91430397
NIA Mouse Gene Index U001929
Consensus CDS Project CCDS16140.1
International Mouse Phenotyping Consortium Status Hoxd11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016551 VEGA Gene Model | MGI Sequence Detail 7460 C57BL/6J ±  kb
transcript OTTMUST00000040001 VEGA | MGI Sequence Detail 1111 Not Applicable 
polypeptide OTTMUSP00000017843 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008718 homeobox protein Hox-D11
References
(Earliest) J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
(Latest) J:216160 Jurberg AD, et al., Compartment-dependent activities of Wnt3a/beta-catenin signaling during vertebrate axial extension. Dev Biol. 2014 Oct 15;394(2):253-63
All references(203)
Other
accession IDs
MGD-MRK-10853, MGD-MRK-10861, MGD-MRK-10904, MGI:2442499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory