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Hoxd11
Gene Detail
 Symbol
Name
ID
Hoxd11
homeobox D11
MGI:96203
STS D2Mit271
Synonyms E230017H14Rik, Hox-4.6, Hox-5.4, Hox-5.5
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr2:74679392-74694194 bp, + strand
From VEGA annotation of GRCm38

  14803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7368  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Hoxd11

Human
homologs
Human Homolog HOXD11, homeobox D11
NCBI Gene ID 3237
neXtProt AC  NX_P31277
Human Synonyms  HOX4, HOX4F
Human Chr (Location)  2q31.1; chr2:176106993-176111835 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Homozygotes for targeted null mutations exhibit homeotic transformations of sacral vertebrae, malformations of distal limbs, and reduced fertility in males.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process anterior/posterior pattern specification, branching involved in ureteric bud morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (140 records)
Data Summary: Results (427)    Tissues (234)    Images (117)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 384
RT-PCR 43
cDNA source data(13)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(33) Genomic(11) cDNA(14) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016551 (Evidence)
Ensembl Gene ModelENSMUSG00000042499 (Evidence)
Entrez Gene15431 (Evidence)
UniGene207763
DFCITC1599639, TC1624899
DoTSDT.91430338, DT.91430397
NIA Mouse Gene IndexU001929
Consensus CDS ProjectCCDS16140.1
International Mouse Knockout Project StatusHoxd11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016551 VEGA Gene Model | MGI Sequence Detail 14803 C57BL/6J ±  kb
transcript OTTMUST00000040001 VEGA | MGI Sequence Detail 1876 Not Applicable 
polypeptide OTTMUSP00000017843 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008718 homeobox protein Hox-D11
References (Earliest) J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
(Latest) J:204375 Sheth R, et al., "Self-regulation," a new facet of Hox genes' function. Dev Dyn. 2014 Jan;243(1):182-91
All references(199)
Other
accession IDs
MGD-MRK-10853, MGD-MRK-10861, MGD-MRK-10904, MGI:2442499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory