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Hoxd11 Gene Detail
Summary
  • Symbol
    Hoxd11
  • Name
    homeobox D11
  • Synonyms
    E230017H14Rik, Hox-4.6, Hox-5.4, Hox-5.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96203
    NCBI Gene: 15431
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:74679557-74687016 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7460 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    22 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    HOXD11, homeobox D11
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HOXD11, homeobox D11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX4, HOX4F
  • Links
    NCBI Gene ID: 3237
    neXtProt AC: NX_P31277
    UniProt: P31277

  • Chr Location
    2q31.1; chr2:176107356-176109588 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    68 phenotypes from multigenic genotypes
    4 images
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit homeotic transformations of sacral vertebrae, malformations of distal limbs, and reduced fertility in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016551 VEGA Gene Model | MGI Sequence Detail 7460 C57BL/6J ±  kb
    transcript OTTMUST00000040001 VEGA | MGI Sequence Detail 1111 Not Applicable  
    polypeptide OTTMUSP00000017843 VEGA | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      18 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic
      IPR017970 Homeobox, conserved site
      IPR001356 Homeobox domain
      IPR020479 Homeobox domain, metazoa
      IPR009057 Homeobox-like domain superfamily
    Molecular
    Reagents
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    • All nucleic 37
      Genomic 11
      cDNA 18
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-10853, MGD-MRK-10861, MGD-MRK-10904, MGI:2442499
    References
    more
    • Summaries
      All 244
      Developmental Gene Expression 162
      Gene Ontology 13
      Phenotypes 81
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory