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Hoxd11 Gene Detail
Summary
  • Symbol
    Hoxd11
  • Name
    homeobox D11
  • Synonyms
    E230017H14Rik, Hox-4.6, Hox-5.4, Hox-5.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96203
    NCBI Gene: 15431
  • Member of
    Hoxd cluster
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74509902-74517360 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96203
protein coding gene Chr2:74509901-74517360 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025847
protein coding gene Chr2:74993757-75001219 (+)
A/J MGP_AJ_G0025825
protein coding gene Chr2:72060817-72068344 (+)
AKR/J MGP_AKRJ_G0025793
protein coding gene Chr2:74014084-74021566 (+)
BALB/cJ MGP_BALBcJ_G0025819
protein coding gene Chr2:72247737-72254987 (+)
C3H/HeJ MGP_C3HHeJ_G0025579
protein coding gene Chr2:74201919-74209385 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026266
protein coding gene Chr2:77227886-77235345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023669
protein coding gene Chr2:69483911-69491484 (+)
CAST/EiJ MGP_CASTEiJ_G0025043
protein coding gene Chr2:74516545-74526529 (+)
CBA/J MGP_CBAJ_G0025560
protein coding gene Chr2:80049034-80056500 (+)
DBA/2J MGP_DBA2J_G0025691
protein coding gene Chr2:71667412-71674897 (+)
FVB/NJ MGP_FVBNJ_G0025653
protein coding gene Chr2:71057127-71064612 (+)
LP/J MGP_LPJ_G0025779
protein coding gene Chr2:74857855-74865354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025684
protein coding gene Chr2:81962636-81970130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026323
protein coding gene Chr2:74129616-74137071 (+)
PWK/PhJ MGP_PWKPhJ_G0024784
protein coding gene Chr2:71597802-71605403 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024592
protein coding gene Chr2:74363454-74370865 (+)
WSB/EiJ MGP_WSBEiJ_G0025111
protein coding gene Chr2:74565574-74573041 (+)



Homology
more
  • Human Ortholog
    HOXD11, homeobox D11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXD11, homeobox D11
  • Synonyms
    HOX4, HOX4F
  • Links
    NCBI Gene ID: 3237
    neXtProt AC: NX_P31277
    UniProt: P31277

  • Chr Location
    2q31.1; chr2:176104216-176115679 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 5 genetic backgrounds
    68 phenotypes from multigenic genotypes
    4 images
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit homeotic transformations of sacral vertebrae, malformations of distal limbs, and reduced fertility in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15431 NCBI Gene Model | MGI Sequence Detail 7459 C57BL/6J ±  kb
    transcript NM_008273 RefSeq | MGI Sequence Detail 3959 Not Specified  
    polypeptide P23813 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 11
      cDNA 20
      Primer pair 10
      Other 37

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10853, MGD-MRK-10861, MGD-MRK-10904, MGI:2442499
    References
    more
    • Summaries
      All 277
      Developmental Gene Expression 185
      Gene Ontology 14
      Phenotypes 93
    • Earliest
      J:21265 Dolle P, et al., Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature. 1989 Dec 14;342(6251):767-72
    • Latest
      J:342014 Chen Y, et al., Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf. Cell Death Differ. 2023 Oct;30(10):2293-2308

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory