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Hoxd10
Gene Detail
 Symbol
Name
ID
Hoxd10
homeobox D10
MGI:96202
STS D2Mit35, D2Mit36, D2Mit37
Synonyms Hox-4.5, Hox-5.3
Feature Type protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:74691090-74695106 bp, + strand
From VEGA annotation of GRCm38

  4017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxd10

Human
homologs
Human Homolog HOXD10, homeobox D10
NCBI Gene ID 3236
neXtProt AC  NX_P28358
Human Synonyms  HOX4, Hox-4.4, HOX4D, HOX4E
Human Chr (Location)  2q31.1; chr2:176116764-176119942 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HOXD10
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit an abnormal gait associated with defects in sacral vertebrae (including homeotic transformations), hindlimb bones, and muscle innervation. These defects are sometimes seen in heterozygotes as well.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process adult locomotory behavior, anterior/posterior pattern specification, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (80 records)
Data Summary: Results (359)    Tissues (195)    Images (89)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 332
RT-PCR 27
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(11) cDNA(17) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016554 (Evidence)
Ensembl Gene ModelENSMUSG00000050368 (Evidence)
Entrez Gene15430 (Evidence)
DFCITC1583366
DoTSDT.40153471, DT.94287496
NIA Mouse Gene IndexU001930
Consensus CDS ProjectCCDS16141.1
International Mouse Knockout Project StatusHoxd10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016554 VEGA Gene Model | MGI Sequence Detail 4017 C57BL/6J ±  kb
transcript OTTMUST00000040007 VEGA | MGI Sequence Detail 2651 Not Applicable 
polypeptide OTTMUSP00000017845 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008717 homeobox protein Hox-D10
References (Earliest) J:9951 Duboule D, et al., The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989 May;8(5):1497-505
(Latest) J:204375 Sheth R, et al., "Self-regulation," a new facet of Hox genes' function. Dev Dyn. 2014 Jan;243(1):182-91
All references(125)
Other
accession IDs
MGD-MRK-10852, MGD-MRK-10860, MGD-MRK-10903, MGI:2138919, MGI:2139108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory