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Hoxd10
Gene Detail
Symbol

Name
ID
Member of
Hoxd10
homeobox D10
MGI:96202
Hoxd cluster
Synonyms
Hox-4.5, Hox-5.3
Feature Type
protein coding gene
Genetic Map
Chromosome 2
44.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:74691924-74695105 bp, + strand
From VEGA annotation of GRCm38

  3182 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXD10
Gene Tree: Hoxd10

Human
homologs
HOXD10, homeobox D10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3236
neXtProt AC: NX_P28358

Human Synonyms: HOX4, Hox-4.4, HOX4D, HOX4E

Human Chr (Location): 2q31.1; chr2:176116764-176119942 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HOXD10

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Spontaneous(1) Targeted(33)
Genomic Mutations involving Hoxd10 (31)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit an abnormal gait associated with defects in sacral vertebrae (including homeotic transformations), hindlimb bones, and muscle innervation. These defects are sometimes seen in heterozygotes as well.
 
Phenotype Images(1)
Interactions
Hoxd10 interacts with 200 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process adult locomotory behavior, anterior/posterior pattern specification, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (359)    Tissues (196)    Images (89)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 332
RT-PCR 27
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXD10 ; Xenbase hoxd10 ; ZFIN hoxd10a    NEW 
Molecular
reagents
All nucleic(34) Genomic(11) cDNA(17) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016554 (Evidence)
Ensembl Gene Model ENSMUSG00000050368 (Evidence)
Entrez Gene 15430 (Evidence)
DFCI TC1583366
DoTS DT.40153471, DT.94287496
NIA Mouse Gene Index U001930
Consensus CDS Project CCDS16141.1
International Mouse Phenotyping Consortium Status Hoxd10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016554 VEGA Gene Model | MGI Sequence Detail 3182 C57BL/6J ±  kb
transcript OTTMUST00000040007 VEGA | MGI Sequence Detail 1816 Not Applicable 
polypeptide OTTMUSP00000017845 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008717 homeobox protein Hox-D10
References
(Earliest) J:9951 Duboule D, et al., The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989 May;8(5):1497-505
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(129)
Other
accession IDs
MGD-MRK-10852, MGD-MRK-10860, MGD-MRK-10903, MGI:2138919, MGI:2139108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory