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Hoxd10 Gene Detail
Summary
  • Symbol
    Hoxd10
  • Name
    homeobox D10
  • Synonyms
    Hox-4.5, Hox-5.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96202
    NCBI Gene: 15430
  • Member of
    Hoxd cluster
  • Gene Overview
    MyGene.info: HOXD10
Location & Maps
more
  • Sequence Map
    Chr2:74691924-74695105 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3182 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HOXD10, homeobox D10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXD10, homeobox D10
    Orthology source: HomoloGene
  • Synonyms
    HOX4, Hox-4.4, HOX4D, HOX4E
  • Links
    NCBI Gene ID: 3236
    neXtProt AC: NX_P28358

  • Chr Location
    2q31.1; chr2:176116764-176119942 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HOXD10 associations

Human Disease Mouse Models
       Vertical Talus, Congenital; CVT   OMIM: 192950
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    37 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    34
  • Genomic Mutations
    34 involving Hoxd10
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit an abnormal gait associated with defects in sacral vertebrae (including homeotic transformations), hindlimb bones, and muscle innervation. These defects are sometimes seen in heterozygotes as well.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016554 VEGA Gene Model | MGI Sequence Detail 3182 C57BL/6J ±  kb
transcript OTTMUST00000040007 VEGA | MGI Sequence Detail 1816 Not Applicable  
polypeptide OTTMUSP00000017845 VEGA | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 34
    Genomic 11
    cDNA 17
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10852, MGD-MRK-10860, MGD-MRK-10903, MGI:2138919, MGI:2139108
References
more
  • Summaries
    All 128
    Developmental Gene Expression 87
    Gene Ontology 10
    Phenotypes 67
  • Earliest
    J:9951 Duboule D, et al., The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989 May;8(5):1497-505
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory