About   Help   FAQ
Hoxc6
Gene Detail
 Symbol
Name
ID
Member of
Hoxc6
homeobox C6
MGI:96197
Hoxc cluster
Synonyms Hox-3.3, Hox-6.1
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.06 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:102998257-103011881 bp, + strand
From VEGA annotation of GRCm38

  13625 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxc6

Human
homologs
Human Homolog HOXC6, homeobox C6
NCBI Gene ID 3223
neXtProt AC  NX_P09630
Human Synonyms  CP25, HHO.C8, HOX3, HOX3C
Human Chr (Location)  12q13.3; chr12:54016852-54030823 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hoxc6 (1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for disruptions in this gene display a transformation of thoracic vertebra 2 to a form similar to that of T1. Mammary glands do not develop normally resulting in poor lactation and poor survival of pups.
 
Interactions
Hoxc6 interacts with 209 markers (Mir7-1, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process anterior/posterior pattern specification, embryonic skeletal system development, ...
Component cytoplasm, nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (312)    Tissues (235)    Images (37)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 250
RT-PCR 55
RNase protection 4
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(11) cDNA(26) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037399 (Evidence)
Ensembl Gene ModelENSMUSG00000001661 (Evidence)
Entrez Gene15425 (Evidence)
UniGene4444
DFCITC1585504, TC1591725
DoTSDT.87068687, DT.87070273, DT.94167558
NIA Mouse Gene IndexU040805
Consensus CDS ProjectCCDS27895.1
International Mouse Knockout Project StatusHoxc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037399 VEGA Gene Model | MGI Sequence Detail 13625 C57BL/6J ±  kb
transcript OTTMUST00000096504 VEGA | MGI Sequence Detail 1675 Not Applicable 
polypeptide OTTMUSP00000053930 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008713 homeobox protein Hox-C6
References (Earliest) J:9353 Sharpe PT, et al., Isolation and expression of a new mouse homeobox gene. Development. 1988 Feb;102(2):397-407
(Latest) J:195163 Lacombe J, et al., Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. PLoS Genet. 2013 Jan;9(1):e1003184
All references(97)
Other
accession IDs
MGD-MRK-10841, MGD-MRK-10865, MGD-MRK-10898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory