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Hoxc4 Gene Detail
Summary
  • Symbol
    Hoxc4
  • Name
    homeobox C4
  • Synonyms
    Hox-3.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96195
    NCBI Gene: 15423
  • Member of
    Hoxc cluster
  • Gene Overview
    MyGene.info: HOXC4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103018934-103036852 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96195
protein coding gene Chr15:103018099-103036856 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022432
protein coding gene Chr15:105254223-105274265 (+)
A/J MGP_AJ_G0022394
protein coding gene Chr15:101098025-101116465 (+)
AKR/J MGP_AKRJ_G0022369
protein coding gene Chr15:104168413-104186315 (+)
BALB/cJ MGP_BALBcJ_G0022398
protein coding gene Chr15:101146154-101164258 (+)
C3H/HeJ MGP_C3HHeJ_G0022165
protein coding gene Chr15:104246230-104266435 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022847
protein coding gene Chr15:109150065-109168505 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020370
protein coding gene Chr15:96867392-96884980 (+)
CAST/EiJ MGP_CASTEiJ_G0021691
protein coding gene Chr15:105120536-105141440 (+)
CBA/J MGP_CBAJ_G0022134
protein coding gene Chr15:112985558-113008382 (+)
DBA/2J MGP_DBA2J_G0022265
protein coding gene Chr15:100368608-100386847 (+)
FVB/NJ MGP_FVBNJ_G0022241
protein coding gene Chr15:99437545-99455448 (+)
LP/J MGP_LPJ_G0022334
protein coding gene Chr15:105390860-105409894 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022263
protein coding gene Chr15:116499197-116519858 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022859
protein coding gene Chr15:104207344-104227467 (+)
PWK/PhJ MGP_PWKPhJ_G0021431
protein coding gene Chr15:100548353-100567189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021263
protein coding gene Chr15:104038091-104057993 (+)
WSB/EiJ MGP_WSBEiJ_G0021741
protein coding gene Chr15:104820461-104841819 (+)



Homology
more
  • Human Ortholog
    HOXC4, homeobox C4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXC4, homeobox C4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cp19, HOX3, HOX3E
  • Links
    NCBI Gene ID: 3221
    neXtProt AC: NX_P09017
    UniProt: P09017

  • Chr Location
    12q13.13; chr12:54016852-54056030 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some postnatal lethality (in the case of one allele but no the other), transformations of thoracic vertebrae, and abnormal rib attachment and sternebra morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000075394 Ensembl Gene Model | MGI Sequence Detail 17919 C57BL/6J ±  kb
    transcript ENSMUST00000100164 Ensembl | MGI Sequence Detail 1983 Not Applicable  
    polypeptide ENSMUSP00000097740 Ensembl | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 7
      cDNA 17
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10843, MGD-MRK-10896
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 37
      Diseases 1
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:266434 Hong SH, et al., Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory