About   Help   FAQ
Hoxc4
Gene Detail
 Symbol
Name
ID
Member of
Hoxc4
homeobox C4
MGI:96195
Hoxc cluster
Synonyms Hox-3.5
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:103018934-103036852 bp, + strand
From VEGA annotation of GRCm38

  17919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxc4

Human
homologs
Human Homolog HOXC4, homeobox C4
NCBI Gene ID 3221
neXtProt AC  NX_P09017
Human Synonyms  cp19, HOX3, HOX3E
Human Chr (Location)  12q13.3; chr12:54016852-54056030 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hoxc4 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit some postnatal lethality (in the case of one allele but no the other), transformations of thoracic vertebrae, and abnormal rib attachment and sternebra morphology.
 
Interactions
Hoxc4 interacts with 204 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process anterior/posterior pattern specification, cartilage development, ...
Component nucleus
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (75)    Tissues (55)    Images (15)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 42
Northern blot 6
RT-PCR 9
RNase protection 14
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(7) cDNA(15) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035136 (Evidence)
Ensembl Gene ModelENSMUSG00000075394 (Evidence)
Entrez Gene15423 (Evidence)
UniGene1351
DFCITC1589932, TC1647762
DoTSDT.110816159, DT.484878
NIA Mouse Gene IndexU016736
Consensus CDS ProjectCCDS27897.1
International Mouse Knockout Project StatusHoxc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035136 VEGA Gene Model | MGI Sequence Detail 17919 C57BL/6J ±  kb
transcript OTTMUST00000089465 VEGA | MGI Sequence Detail 1983 Not Applicable 
polypeptide OTTMUSP00000048894 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(16) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008711 homeobox protein Hox-C4
References (Earliest) J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
(Latest) J:195163 Lacombe J, et al., Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. PLoS Genet. 2013 Jan;9(1):e1003184
All references(56)
Other
accession IDs
MGD-MRK-10843, MGD-MRK-10896

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory