Hoxc12 MGI Mouse Gene Detail - MGI:96194

Symbol

Hoxc12
Name

homeobox C12
Synonyms

Hox-3.8

Feature Type

protein coding gene
IDs

MGI:96194
NCBI Gene: 15421
Member of

Hoxc cluster
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:102845261-102847044 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.01 cM
Mapping Data

4 experiments

SNPs within 2kb

76 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96194	protein coding gene	Chr15:102845192-102847044 (+)
129S1/SvImJ	ENSMUSG00200048684	protein coding gene	Chr15:100070158-100072019 (+)
A/J	ENSMUSG00195044224	protein coding gene	Chr15:99959330-99961191 (+)
AKR/J	ENSMUSG00220048208	protein coding gene	Chr15:99929259-99931107 (+)
BALB/cJ	ENSMUSG00180038703	protein coding gene	Chr15:99842819-99844681 (+)
C3H/HeJ	ENSMUSG00175035000	protein coding gene	Chr15:100166496-100168354 (+)
C57BL/6NJ	ENSMUSG00215050828	protein coding gene	Chr15:99886244-99888096 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020363	protein coding gene	Chr15:96785073-96786926 (+)
CAST/EiJ	ENSTCUG00005043565	protein coding gene	Chr15:99360770-99362620 (+)
CBA/J	ENSMUSG00210029784	protein coding gene	Chr15:99912332-99914193 (+)
DBA/2J	ENSMUSG00185034650	protein coding gene	Chr15:99929108-99930956 (+)
FVB/NJ	ENSMUSG00205021610	protein coding gene	Chr15:99633881-99635729 (+)
JF1/MsJ	ENSUMUG00000050502	protein coding gene	Chr15:99389838-99391688 (+)
LP/J	ENSMUSG00230005347	protein coding gene	Chr15:103291156-103293017 (+)
NOD/ShiLtJ	ENSMUSG00190044859	protein coding gene	Chr15:99873936-99875784 (+)
NZO/HlLtJ	ENSMUSG00225026892	protein coding gene	Chr15:103475764-103477618 (+)
PWK/PhJ	ENSLUMG00010044651	protein coding gene	Chr15:99599864-99601721 (+)
SPRET/EiJ	ENSMSPG00010046720	protein coding gene	Chr15:101385027-101386886 (+)
WSB/EiJ	ENSIUOG00005030088	protein coding gene	Chr15:100013247-100015098 (+)

Human Ortholog

HOXC12, homeobox C12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXC12, homeobox C12
Synonyms

HOC3F, HOX3, HOX3F
Links

HGNC:5124

NCBI Gene ID: 3228

UniProt: P31275
Chr Location

12q13.13; chr12:53954903-53958956 (+) GRCh38

MGI Vertebrate Homology

Hoxc12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HOXC12
Gene Tree

Hoxc12

less

References

1 with disease annotations

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

2
Targeted

5
Genomic Mutations

4 involving Hoxc12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

less

All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

84
cDNA Data

7
Literature Summary

20

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hoxc12

ZFIN hoxc12a, hoxc12b

less

All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS27891.1

Ensembl

ENSMUSG00000050328 (Evidence)
NCBI Gene

15421

			Length	Strain/Species	Flank
genomic	15421	NCBI Gene Model \| MGI Sequence Detail	1784	C57BL/6J	± kb
transcript	NM_010463	RefSeq \| MGI Sequence Detail	962	Not Specified
polypeptide	Q8K5B8	UniProt \| EBI \| MGI Sequence Detail	280	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000008709 homeobox protein Hox-C12

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeodomain

IPR009057 Homeodomain-like superfamily

IPR020479 Homeodomain, metazoa

less

All nucleic 24

Genomic 6

cDNA 8

Primer pair 7

Other 3

Microarray probesets 1

less

MGD-MRK-10846, MGD-MRK-10895

Summaries

All 76

Developmental Gene Expression 20

Diseases 1

Gene Ontology 6

Phenotypes 36
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Hoxc12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133475	Chr15:102845251-102845269 (+)	-1 bp
Tssr133476	Chr15:102845277-102845289 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24