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Hoxc11 Gene Detail
Summary
  • Symbol
    Hoxc11
  • Name
    homeobox C11
  • Synonyms
    Hox-3.7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96193
    NCBI Gene: 109663
  • Member of
    Hoxc cluster
  • Gene Overview
    MyGene.info: HOXC11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102954526-102956701 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96193
protein coding gene Chr15:102954427-102957708 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022426
protein coding gene Chr15:105190011-105193292 (+)
A/J MGP_AJ_G0022388
protein coding gene Chr15:101033120-101036401 (+)
AKR/J MGP_AKRJ_G0022363
protein coding gene Chr15:104102389-104105672 (+)
BALB/cJ MGP_BALBcJ_G0022392
protein coding gene Chr15:101080748-101084029 (+)
C3H/HeJ MGP_C3HHeJ_G0022159
protein coding gene Chr15:104179031-104182312 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022841
protein coding gene Chr15:109084590-109087906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020364
protein coding gene Chr15:96802621-96805911 (+)
CAST/EiJ MGP_CASTEiJ_G0021685
protein coding gene Chr15:105052376-105055628 (+)
CBA/J MGP_CBAJ_G0022128
protein coding gene Chr15:112918518-112921799 (+)
DBA/2J MGP_DBA2J_G0022259
protein coding gene Chr15:100303421-100306703 (+)
FVB/NJ MGP_FVBNJ_G0022235
protein coding gene Chr15:99373086-99376368 (+)
LP/J MGP_LPJ_G0022328
protein coding gene Chr15:105325147-105328428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022257
protein coding gene Chr15:116433795-116437077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022853
protein coding gene Chr15:104141187-104144470 (+)
PWK/PhJ MGP_PWKPhJ_G0021425
protein coding gene Chr15:100482694-100485979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021257
protein coding gene Chr15:103971000-103974279 (+)
WSB/EiJ MGP_WSBEiJ_G0021735
protein coding gene Chr15:104755880-104759164 (+)



Homology
more
  • Human Ortholog
    HOXC11, homeobox C11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HOXC11, homeobox C11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX3H
  • Links
    NCBI Gene ID: 3227
    neXtProt AC: NX_O43248
    UniProt: O43248

  • Chr Location
    12q13.13; chr12:53973126-53976419 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from multigenic genotypes
    31 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109663 NCBI Gene Model | MGI Sequence Detail 2176 C57BL/6J ±  kb
transcript NM_001024842 RefSeq | MGI Sequence Detail 915 Not Specified  
polypeptide P31313 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic
    IPR017970 Homeobox, conserved site
    IPR001356 Homeobox domain
    IPR020479 Homeobox domain, metazoa
    IPR009057 Homeobox-like domain superfamily
Molecular
Reagents
less
  • All nucleic 21
    Genomic 6
    cDNA 10
    Primer pair 4
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10845, MGD-MRK-10894
References
more
  • Summaries
    All 78
    Developmental Gene Expression 27
    Diseases 1
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:272567 Aires R, et al., Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes. Dev Cell. 2019 Feb 11;48(3):383-395.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory