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Hoxc10 Gene Detail
Summary
  • Symbol
    Hoxc10
  • Name
    homeobox C10
  • Synonyms
    Hox-3.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96192
    NCBI Gene: 209448
  • Member of
    Hoxc cluster
  • Gene Overview
    MyGene.info: HOXC10
Location & Maps
more
  • Sequence Map
    Chr15:102966796-102971893 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5098 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.03 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    HOXC10, homeobox C10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXC10, homeobox C10
    Orthology source: HomoloGene
  • Synonyms
    HOX3I
  • Links
    NCBI Gene ID: 3226
    neXtProt AC: NX_Q9NYD6

  • Chr Location
    12q13.3; chr12:53985162-53990279 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Hoxc10
  • Incidental Mutations
Mice homozygous for a null allele exhibit skeletal transformations in thoracic, lumbar and sacral vertebrae, alterations in the pelvis and in the bones and ligaments of the hindlimb, femoral defects, decreased lumbar motor neuron and rib number, impairedcoordination, muscle wasting, and obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037394 VEGA Gene Model | MGI Sequence Detail 5098 C57BL/6J ±  kb
transcript OTTMUST00000096496 VEGA | MGI Sequence Detail 1909 Not Applicable  
polypeptide OTTMUSP00000053924 VEGA | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 28
    Genomic 6
    cDNA 18
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10844, MGD-MRK-10893, MGI:2146032
References
more
  • Summaries
    All 76
    Developmental Gene Expression 45
    Diseases 1
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
  • Latest
    J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory