Hoxc10 MGI Mouse Gene Detail - MGI:96192

Symbol

Hoxc10
Name

homeobox C10
Synonyms

Hox-3.6

Feature Type

protein coding gene
IDs

MGI:96192
NCBI Gene: 209448
Member of

Hoxc cluster
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:102875231-102880328 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.03 cM
Mapping Data

5 experiments

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96192	protein coding gene	Chr15:102875231-102880333 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022427	protein coding gene	Chr15:105202350-105207423 (+)
A/J	MGP_AJ_G0022389	protein coding gene	Chr15:101045469-101050534 (+)
AKR/J	MGP_AKRJ_G0022364	protein coding gene	Chr15:104114740-104119817 (+)
BALB/cJ	MGP_BALBcJ_G0022393	protein coding gene	Chr15:101093484-101098566 (+)
C3H/HeJ	MGP_C3HHeJ_G0022160	protein coding gene	Chr15:104191388-104196472 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022842	protein coding gene	Chr15:109096954-109103087 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020365	protein coding gene	Chr15:96814963-96820212 (+)
CAST/EiJ	MGP_CASTEiJ_G0021686	protein coding gene	Chr15:105064693-105069800 (+)
CBA/J	MGP_CBAJ_G0022129	protein coding gene	Chr15:112930876-112935943 (+)
DBA/2J	MGP_DBA2J_G0022260	protein coding gene	Chr15:100315798-100320902 (+)
FVB/NJ	MGP_FVBNJ_G0022236	protein coding gene	Chr15:99385429-99390502 (+)
LP/J	MGP_LPJ_G0022329	protein coding gene	Chr15:105337490-105342575 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022258	protein coding gene	Chr15:116446150-116451266 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022854	protein coding gene	Chr15:104153583-104158672 (+)
PWK/PhJ	MGP_PWKPhJ_G0021426	protein coding gene	Chr15:100495061-100500359 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021258	protein coding gene	Chr15:103983394-103988480 (+)
WSB/EiJ	MGP_WSBEiJ_G0021736	protein coding gene	Chr15:104768240-104773350 (+)

Human Ortholog

HOXC10, homeobox C10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXC10, homeobox C10
Synonyms

HOX3I
Links

HGNC:5122

NCBI Gene ID: 3226

UniProt: Q9NYD6
Chr Location

12q13.13; chr12:53985065-53990279 (+) GRCh38

MGI Vertebrate Homology

Hoxc10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOXC10
Gene Tree

Hoxc10

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References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
14 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Radiation induced

2
Targeted

6
Genomic Mutations

5 involving Hoxc10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit skeletal transformations in thoracic, lumbar and sacral vertebrae, alterations in the pelvis and in the bones and ligaments of the hindlimb, femoral defects, decreased lumbar motor neuron and rib number, impairedcoordination, muscle wasting, and obesity.

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All GO Annotations

39
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1185
Tissues

306
cDNA Data

21
Literature Summary

62

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXC10

Xenbase hoxc10

ZFIN hoxc10a

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS57014.1

Ensembl

ENSMUSG00000022484 (Evidence)
NCBI Gene

209448

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022484	Ensembl Gene Model \| MGI Sequence Detail	5098	C57BL/6J	± kb
transcript	ENSMUST00000001699	Ensembl \| MGI Sequence Detail	1909	Not Applicable
polypeptide	ENSMUSP00000001699	Ensembl \| MGI Sequence Detail	342	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008707 homeobox protein Hox-C10

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR046333 Homeobox protein Hox-A10/abdominal-B-like

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All nucleic 38

Genomic 6

cDNA 21

Primer pair 4

Other 7

Microarray probesets 3

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MGD-MRK-10844, MGD-MRK-10893, MGI:2146032

Summaries

All 125

Developmental Gene Expression 62

Diseases 1

Gene Ontology 10

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:364860 Wang H, et al., The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability. Elife. 2024 Nov 11;13

TSS for Hoxc10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133477	Chr15:102875174-102875186 (+)	-51 bp
Tssr133478	Chr15:102875187-102875209 (+)	-33 bp
Tssr133479	Chr15:102875229-102875247 (+)	7 bp
Tssr133480	Chr15:102875292-102875306 (+)	68 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24