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Hoxc10
Gene Detail
Symbol

Name
ID
Member of
Hoxc10
homeobox C10
MGI:96192
Hoxc cluster
Synonyms
Hox-3.6
Feature Type
protein coding gene
Genetic Map
Chromosome 15
58.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:102966796-102971893 bp, + strand
From VEGA annotation of GRCm38

  5098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXC10
Gene Tree: Hoxc10

Human
homologs
HOXC10, homeobox C10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3226
neXtProt AC: NX_Q9NYD6

Human Synonyms: HOX3I

Human Chr (Location): 12q13.3; chr12:53985162-53990279 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hoxc10 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit skeletal transformations in thoracic, lumbar and sacral vertebrae, alterations in the pelvis and in the bones and ligaments of the hindlimb, femoral defects, decreased lumbar motor neuron and rib number, impaired coordination, muscle wasting, and obesity.
 
Phenotype Images(2)
Interactions
Hoxc10 interacts with 160 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (44 records)
Data Summary: Results (380)    Tissues (267)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 253
In situ reporter (knock in) 12
Northern blot 12
RT-PCR 101
RNase protection 2
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXC10 ; Xenbase hoxc10 ; ZFIN hoxc10a    NEW 
Molecular
reagents
All nucleic(28) Genomic(6) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037394 (Evidence)
Ensembl Gene Model ENSMUSG00000022484 (Evidence)
Entrez Gene 209448 (Evidence)
UniGene 31665
DFCI TC1585706, TC1661934
DoTS DT.40181383
NIA Mouse Gene Index U016730
Consensus CDS Project CCDS57014.1
International Mouse Phenotyping Consortium Status Hoxc10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037394 VEGA Gene Model | MGI Sequence Detail 5098 C57BL/6J ±  kb
transcript OTTMUST00000096496 VEGA | MGI Sequence Detail 1909 Not Applicable 
polypeptide OTTMUSP00000053924 VEGA | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008707 homeobox protein Hox-C10
References
(Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(78)
Other
accession IDs
MGD-MRK-10844, MGD-MRK-10893, MGI:2146032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory