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Hoxc10
Gene Detail
 Symbol
Name
ID
Member of
Hoxc10
homeobox C10
MGI:96192
Hoxc cluster
Synonyms Hox-3.6
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:102966796-102971893 bp, + strand
From VEGA annotation of GRCm38

  5098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hoxc10

Human
homologs
Human Homolog HOXC10, homeobox C10
NCBI Gene ID 3226
neXtProt AC  NX_Q9NYD6
Human Synonyms  HOX3I
Human Chr (Location)  12q13.3; chr12:53985162-53990279 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hoxc10 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit skeletal transformations in thoracic, lumbar and sacral vertebrae, alterations in the pelvis and in the bones and ligaments of the hindlimb, femoral defects, decreased lumbar motor neuron and rib number, impaired coordination, muscle wasting, and obesity.
 
Interactions
Hoxc10 interacts with 160 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process anterior/posterior pattern specification, embryonic limb morphogenesis, ...
Component cyclin-dependent protein kinase activating kinase holoenzyme complex, nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (380)    Tissues (267)    Images (45)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 253
In situ reporter (knock in) 12
Northern blot 12
RT-PCR 101
RNase protection 2
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(6) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037394 (Evidence)
Ensembl Gene ModelENSMUSG00000022484 (Evidence)
Entrez Gene209448 (Evidence)
UniGene31665
DFCITC1585706, TC1661934
DoTSDT.40181383
NIA Mouse Gene IndexU016730
Consensus CDS ProjectCCDS57014.1
International Mouse Knockout Project StatusHoxc10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037394 VEGA Gene Model | MGI Sequence Detail 5098 C57BL/6J ±  kb
transcript OTTMUST00000096496 VEGA | MGI Sequence Detail 1909 Not Applicable 
polypeptide OTTMUSP00000053924 VEGA | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008707 homeobox protein Hox-C10
References (Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(76)
Other
accession IDs
MGD-MRK-10844, MGD-MRK-10893, MGI:2146032

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory