Hoxc10
Gene Detail

Symbol

Name
ID
Member of

Hoxc10
homeobox C10
MGI:96192
Hoxc cluster

Synonyms

Hox-3.6

Feature Type

protein coding gene

Genetic Map

Chromosome 15
58.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:102966796-102971893 bp, + strand From VEGA annotation of GRCm38   5098 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:9680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hoxc10

Human
homologs

Human Homolog		HOXC10, homeobox C10
NCBI Gene ID		3226
neXtProt AC		NX_Q9NYD6
Human Synonyms		HOX3I
Human Chr (Location)		12q13.3; chr12:53985162-53990279 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Hoxc10 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit skeletal transformations in thoracic, lumbar and sacral vertebrae, alterations in the pelvis and in the bones and ligaments of the hindlimb, femoral defects, decreased lumbar motor neuron and rib number, impaired coordination, muscle wasting, and obesity.

 
Phenotype Images(2)

Interactions

Hoxc10 interacts with 160 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (16 annotations)

Process	anterior/posterior pattern specification, embryonic limb morphogenesis, ...
Component	cyclin-dependent protein kinase activating kinase holoenzyme complex, nucleoplasm, ...
Function	DNA binding, sequence-specific DNA binding

External Resources: FuncBase

Expression

Literature Summary: (42 records)

Data Summary: Results (380)    Tissues (267)    Images (45)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	253
In situ reporter (knock in)	12
Northern blot	12
RT-PCR	101
RNase protection	2

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(28) Genomic(6) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000037394 (Evidence)
Ensembl Gene Model	ENSMUSG00000022484 (Evidence)
Entrez Gene	209448 (Evidence)
UniGene	31665
DFCI	TC1585706, TC1661934
DoTS	DT.40181383
NIA Mouse Gene Index	U016730
Consensus CDS Project	CCDS57014.1
International Mouse Knockout Project Status	Hoxc10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037394	VEGA Gene Model | MGI Sequence Detail	5098	C57BL/6J
transcript	OTTMUST00000096496	VEGA | MGI Sequence Detail	1909	Not Applicable
polypeptide	OTTMUSP00000053924	VEGA | MGI Sequence Detail	342	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(38 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008707	homeobox protein Hox-C10

References

(Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:211197 Nishimoto S, et al., A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. PLoS Genet. 2014 Mar;10(3):e1004245
All references(78)

Other
accession IDs

MGD-MRK-10844, MGD-MRK-10893, MGI:2146032