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Hoxb7
Gene Detail
Symbol

Name
ID
Member of
Hoxb7
homeobox B7
MGI:96188
Hoxb cluster
Synonyms
Hox-2.3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr11:96286623-96290162 bp, + strand
From VEGA annotation of GRCm38

  3540 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A7
Gene Tree: Hoxb7

Human
homologs
Human Homolog HOXB7, homeobox B7
NCBI Gene ID 3217
neXtProt AC  NX_P09629
Human Synonyms  HHO.C1, HOX2, Hox-2.3, HOX2C
Human Chr (Location)  17q21.3; chr17:48607232-48611021 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Hoxb7 (1)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit first and second rib defects.
 
Interactions
Hoxb7 interacts with 111 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process anterior/posterior pattern specification, embryonic skeletal system morphogenesis, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (214)    Tissues (154)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
Northern blot 8
RT-PCR 6
RNase protection 3
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(18) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000001989 (Evidence)
Ensembl Gene ModelENSMUSG00000038721 (Evidence)
Entrez Gene15415 (Evidence)
UniGene390366
DFCITC1585082
Consensus CDS ProjectCCDS25294.1
International Mouse Knockout Project StatusHoxb7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001989 VEGA Gene Model | MGI Sequence Detail 3540 C57BL/6J ±  kb
transcript OTTMUST00000003993 VEGA | MGI Sequence Detail 1291 Not Applicable 
polypeptide OTTMUSP00000001931 VEGA | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008704 homeobox protein Hox-B7
References
(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
All references(93)
Other
accession IDs
MGD-MRK-10831, MGD-MRK-10889, MGI:2144127

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory