Hoxb7
Gene Detail

Symbol Name ID

Hoxb7 homeobox B7 MGI:96188

Synonyms

Hox-2.3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr11:96284257-96290336 bp, + strand From VEGA annotation of GRCm38   6080 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A7
Gene Tree: Hoxb7

Human homologs

Human Homolog		HOXB7, homeobox B7
NCBI Gene ID		3217
neXtProt AC		NX_P09629
Human Synonyms		HHO.C1, HOX2, Hox-2.3, HOX2C
Human Chr (Location)		17q21.3; chr17:46684594-46688383 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a targeted null mutation exhibit first and second rib defects.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	anterior/posterior pattern specification, embryonic skeletal system morphogenesis, ...
Component	cytoplasm, nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (194)    Tissues (141)    Images (30)
Theiler Stages: 11, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	177
Northern blot	8
RT-PCR	6
RNase protection	3

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(18) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000001989 (Evidence)
Ensembl Gene Model	ENSMUSG00000038721 (Evidence)
Entrez Gene	15415 (Evidence)
UniGene	390366
DFCI	TC1585082
Consensus CDS Project	CCDS25294.1
International Mouse Knockout Project Status	Hoxb7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001989	VEGA Gene Model | MGI Sequence Detail	6080	C57BL/6J
transcript	OTTMUST00000003993	VEGA | MGI Sequence Detail	3831	Not Applicable
polypeptide	OTTMUSP00000001931	VEGA | MGI Sequence Detail	217	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR017995	Homeobox protein, antennapedia type
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008704	homeobox protein Hox-B7

References

(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:173614 Paul D, et al., HOX genes are expressed in bovine and mouse oocytes and early embryos. Mol Reprod Dev. 2011 Jun;78(6):436-49
All references(91)

Other accession IDs

MGD-MRK-10831, MGD-MRK-10889, MGI:2144127