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Hoxb7 Gene Detail
Summary
  • Symbol
    Hoxb7
  • Name
    homeobox B7
  • Synonyms
    Hox-2.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96188
    NCBI Gene: 15415
  • Member of
    Hoxb cluster
Location & Maps
more
  • Sequence Map
    Chr11:96286623-96290162 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3540 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HOXB7, homeobox B7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HOXB7, homeobox B7
    Orthology source: HomoloGene
  • Synonyms
    HHO.C1, HOX2, Hox-2.3, HOX2C
  • Links
    NCBI Gene ID: 3217
    neXtProt AC: NX_P09629

  • Chr Location
    17q21.3; chr17:48607232-48611021 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    3 involving Hoxb7
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit first and second rib defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001989 VEGA Gene Model | MGI Sequence Detail 3540 C57BL/6J ±  kb
transcript OTTMUST00000003993 VEGA | MGI Sequence Detail 1291 Not Applicable  
polypeptide OTTMUSP00000001931 VEGA | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 42
    Genomic 18
    cDNA 21
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10831, MGD-MRK-10889, MGI:2144127
References
more
  • Summaries
    All 92
    Developmental Gene Expression 32
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
  • Latest
    J:226712 Wong SF, et al., Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4884-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory