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Hoxb4 Gene Detail
Summary
  • Symbol
    Hoxb4
  • Name
    homeobox B4
  • Synonyms
    Hox-2.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96185
    NCBI Gene: 15412
  • Member of
    Hoxb cluster
  • Gene Overview
    MyGene.info: HOXB4
Location & Maps
more
  • Sequence Map
    Chr11:96318267-96321638 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3372 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HOXB4, homeobox B4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXB4, homeobox B4
    Orthology source: HomoloGene
  • Synonyms
    HOX2, HOX-2.6, HOX2F
  • Links
    NCBI Gene ID: 3214
    neXtProt AC: NX_P17483

  • Chr Location
    17q21.32; chr17:48575507-48578381 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 8 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Targeted
    14
  • Genomic Mutations
    4 involving Hoxb4
  • Incidental Mutations
Homozygous disruption of this gene causes cervical vertebral transformation and may lead to pre- or neonatal lethality, sternal defects, impaired ventral body wall formation, diaphragm hernias and heart anomalies. Homozygotes for a null allele show a proliferation defect in hematopoietic stem cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001777 VEGA Gene Model | MGI Sequence Detail 3372 C57BL/6J ±  kb
transcript OTTMUST00000003562 VEGA | MGI Sequence Detail 2566 Not Applicable  
polypeptide OTTMUSP00000001716 VEGA | MGI Sequence Detail 250 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 55
    Genomic 20
    cDNA 31
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10834, MGD-MRK-10886
References
more
  • Summaries
    All 134
    Developmental Gene Expression 81
    Gene Ontology 12
    Phenotypes 22
  • Earliest
    J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory