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Hoxb4
Gene Detail
Symbol

Name
ID
Member of
Hoxb4
homeobox B4
MGI:96185
Hoxb cluster
Synonyms
Hox-2.6
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:96318267-96321638 bp, + strand
From VEGA annotation of GRCm38

  3372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXB4
Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxb4

Human
homologs
HOXB4, homeobox B4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3214
neXtProt AC: NX_P17483

Human Synonyms: HOX2, HOX-2.6, HOX2F

Human Chr (Location): 17q21.32; chr17:48575507-48578381 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Genomic Mutations involving Hoxb4 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene causes cervical vertebral transformation and may lead to pre- or neonatal lethality, sternal defects, impaired ventral body wall formation, diaphragm hernias and heart anomalies. Homozygotes for a null allele show a proliferation defect in hematopoietic stem cells.
 
Interactions
Hoxb4 interacts with 199 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process anterior/posterior pattern specification, bone marrow development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (79 records)
Data Summary: Results (408)    Tissues (244)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 357
RT-PCR 10
RNase protection 13
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXB4 ; Xenbase hoxb4 ; ZFIN hoxb4a    NEW 
Molecular
reagents
All nucleic(55) Genomic(20) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000001777 (Evidence)
Ensembl Gene Model ENSMUSG00000038692 (Evidence)
Entrez Gene 15412 (Evidence)
UniGene 3546
DFCI TC1591214, TC1638091
DoTS DT.486598, DT.94156876, DT.97390227
NIA Mouse Gene Index U013247
Consensus CDS Project CCDS25297.1
International Mouse Phenotyping Consortium Status Hoxb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001777 VEGA Gene Model | MGI Sequence Detail 3372 C57BL/6J ±  kb
transcript OTTMUST00000003562 VEGA | MGI Sequence Detail 2566 Not Applicable 
polypeptide OTTMUSP00000001716 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008701 homeobox protein Hox-B4
References
(Earliest) J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
(Latest) J:221396 Sheikh BN, et al., MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5437-42
All references(135)
Other
accession IDs
MGD-MRK-10834, MGD-MRK-10886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory