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Hoxb4 Gene Detail
Summary
  • Symbol
    Hoxb4
  • Name
    homeobox B4
  • Synonyms
    Hox-2.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96185
    NCBI Gene: 15412
  • Member of
    Hoxb cluster
  • Gene Overview
    MyGene.info: HOXB4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:96318267-96321638 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3372 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.83 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    HOXB4, homeobox B4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXB4, homeobox B4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX2, HOX-2.6, HOX2F
  • Links
    NCBI Gene ID: 3214
    neXtProt AC: NX_P17483
    UniProt: P17483

  • Chr Location
    17q21.32; chr17:48575507-48578381 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 8 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene causes cervical vertebral transformation and may lead to pre- or neonatal lethality, sternal defects, impaired ventral body wall formation, diaphragm hernias and heart anomalies. Homozygotes for a null allele show a proliferation defect in hematopoietic stem cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001777 VEGA Gene Model | MGI Sequence Detail 3372 C57BL/6J ±  kb
    transcript OTTMUST00000003562 VEGA | MGI Sequence Detail 2566 Not Applicable  
    polypeptide OTTMUSP00000001716 VEGA | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      4 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 56
      Genomic 20
      cDNA 32
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10834, MGD-MRK-10886
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 84
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
    • Latest
      J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory