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Hoxb3
Gene Detail
Symbol

Name
ID
Member of
Hoxb3
homeobox B3
MGI:96184
Hoxb cluster
Synonyms
Hox-2.7
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:96323326-96347930 bp, + strand
From VEGA annotation of GRCm38

  24605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B3
Gene Tree: Hoxb3

Human
homologs
Human Homolog HOXB3, homeobox B3
NCBI Gene ID 3213
neXtProt AC  NX_P14651
Human Synonyms  HOX2, Hox-2.7, HOX2G
Human Chr (Location)  17q21.3; chr17:48548870-48590272 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Hoxb3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display partial neonatal lethality and mild and low penetrance defects in the formation of the anterior arch of the atlas and the IXth cranial nerve.
 
Interactions
Hoxb3 interacts with 91 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process anterior/posterior pattern specification, cartilage development, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (303)    Tissues (153)    Images (89)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 292
RT-PCR 8
RNase protection 3
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(7) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001781 (Evidence)
Ensembl Gene ModelENSMUSG00000048763 (Evidence)
Entrez Gene15410 (Evidence)
UniGene342481
DFCITC1591291, TC1708740, TC1724156
DoTSDT.110523981, DT.94304415
NIA Mouse Gene IndexU111227
Consensus CDS ProjectCCDS25299.1
International Mouse Knockout Project StatusHoxb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001781 VEGA Gene Model | MGI Sequence Detail 24605 C57BL/6J ±  kb
transcript OTTMUST00000003950 VEGA | MGI Sequence Detail 3190 Not Applicable 
polypeptide OTTMUSP00000001912 VEGA | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(26) UniProt(5)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025281 Domain of unknown function DUF4074
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008700 homeobox protein Hox-B3
References
(Earliest) J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
(Latest) J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
All references(102)
Other
accession IDs
MGD-MRK-10835, MGD-MRK-10885

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory