Hoxb2
Gene Detail

Symbol Name ID

Hoxb2 homeobox B2 MGI:96183

Synonyms

Hox-2.8, Hoxbes2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:96351632-96355689 bp, + strand From VEGA annotation of GRCm38   4058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B2
Gene Tree: Hoxb2

Human homologs

Human Homolog		HOXB2, homeobox B2
NCBI Gene ID		3212
neXtProt AC		NX_P14652
Human Synonyms		HOX2, Hox-2.8, HOX2H, K8
Human Chr (Location)		17q21.32; chr17:46620017-46622393 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)
 

Most homozygotes for targeted null mutations die at birth, usually with severe defects of the sternum. Mutants that survive to weaning show facial paralysis with defects of the somatic motor component of the seventh facial nerve, and later die.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	anterior/posterior pattern specification, dorsal/ventral pattern formation, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (46 records)
Data Summary: Results (216)    Tissues (117)    Images (49)
Theiler Stages: 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	192
Northern blot	10
RT-PCR	6
RNase protection	8

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(4) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001779 (Evidence)
Ensembl Gene Model	ENSMUSG00000075588 (Evidence)
Entrez Gene	103889 (Evidence)
DFCI	TC1585859, TC1667673
DoTS	DT.40156075, DT.40157969, DT.94397623
NIA Mouse Gene Index	U013251, U082055
Consensus CDS Project	CCDS36290.1
International Mouse Knockout Project Status	Hoxb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001779	VEGA Gene Model | MGI Sequence Detail	4058	C57BL/6J
transcript	OTTMUST00000003569	VEGA | MGI Sequence Detail	3304	Not Applicable
polypeptide	OTTMUSP00000001717	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008699	homeobox protein Hox-B2

References

(Earliest) J:32270 Wilkinson DG, et al., Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature. 1989 Oct 5;341(6241):405-9
(Latest) J:193058 Miguez A, et al., Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning. J Neurosci. 2012 Nov 28;32(48):17172-85
All references(87)

Other accession IDs

MGD-MRK-10836, MGD-MRK-10884, MGI:2144329