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Hoxb2
Gene Detail
Symbol

Name
ID
Member of
Hoxb2
homeobox B2
MGI:96183
Hoxb cluster
Synonyms
Hox-2.8, Hoxbes2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:96350525-96354012 bp, + strand
From VEGA annotation of GRCm38

  3488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B2
Gene Tree: Hoxb2

Human
homologs
Human Homolog HOXB2, homeobox B2
NCBI Gene ID 3212
neXtProt AC  NX_P14652
Human Synonyms  HOX2, Hox-2.8, HOX2H, K8
Human Chr (Location)  17q21.32; chr17:48542655-48545031 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Hoxb2 (1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a reporter allele die neonatally with altered segmental identity and abnormal migration of motor neurons in the hindbrain. Mice homozygous for null alleles can exhibit partial postnatal lethality, narrow face, runting, absent facial motor nuclei, and facial nerve/muscle defects.
 
Interactions
Hoxb2 interacts with 231 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process anterior/posterior pattern specification, dorsal/ventral pattern formation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (216)    Tissues (121)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
Northern blot 10
RT-PCR 6
RNase protection 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001779 (Evidence)
Ensembl Gene ModelENSMUSG00000075588 (Evidence)
Entrez Gene103889 (Evidence)
DFCITC1585859, TC1667673
DoTSDT.40156075, DT.40157969, DT.94397623
NIA Mouse Gene IndexU013251, U082055
Consensus CDS ProjectCCDS36290.1
International Mouse Knockout Project StatusHoxb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001779 VEGA Gene Model | MGI Sequence Detail 3488 C57BL/6J ±  kb
transcript OTTMUST00000003569 VEGA | MGI Sequence Detail 1628 Not Applicable 
polypeptide OTTMUSP00000001717 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008699 homeobox protein Hox-B2
References
(Earliest) J:32270 Wilkinson DG, et al., Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature. 1989 Oct 5;341(6241):405-9
(Latest) J:208763 Ahn Y, et al., Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development. Dev Biol. 2014 Apr 1;388(1):134-44
All references(88)
Other
accession IDs
MGD-MRK-10836, MGD-MRK-10884, MGI:2144329

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory