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Hoxa4
Gene Detail
Symbol

Name
ID
Member of
Hoxa4
homeobox A4
MGI:96176
Hoxa cluster
Synonyms
Hox-1.4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:52189671-52191753 bp, - strand
From VEGA annotation of GRCm38

  2083 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37583  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 3 chicken; 1 western clawed frog

HCOP human homology predictions: HOXA4
Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxa4

Human
homologs
HOXA4, homeobox A4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3201
neXtProt AC: NX_Q00056

Human Synonyms: HOX1, HOX1D

Human Chr (Location): 7p15.2; chr7:27128507-27130780 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Hoxa4 (1)
Incidental mutations (data from APF )
 
Homozygous inactivation of this gene leads to homeotic transformation of cervical vertebrae. Mice homozygous for a knock-out allele also exhibit a hunched appearance of the pectoral girdle. Mice homozygous for a different knock-out allele show additional sternal defects.
 
Phenotype Images(3)
Interactions
Hoxa4 interacts with 141 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process anterior/posterior pattern specification, embryonic skeletal system morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (258)    Tissues (142)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 201
Northern blot 31
RT-PCR 17
RNase protection 4
Nuclease S1 5
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXA4 ZFIN hoxa4a    NEW 
Molecular
reagents
All nucleic(44) Genomic(12) cDNA(23) Primer pair(5) Other(4)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000018878 (Evidence)
Ensembl Gene Model ENSMUSG00000000942 (Evidence)
Entrez Gene 15401 (Evidence)
DFCI TC1587292, TC1672010
DoTS DT.482326, DT.91564171, DT.94244305, DT.97396941
NIA Mouse Gene Index U027305
Consensus CDS Project CCDS20142.1
International Mouse Phenotyping Consortium Status Hoxa4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018878 VEGA Gene Model | MGI Sequence Detail 2083 C57BL/6J ±  kb
transcript OTTMUST00000045407 VEGA | MGI Sequence Detail 1594 Not Applicable 
polypeptide OTTMUSP00000020423 VEGA | MGI Sequence Detail 285 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008692 homeobox protein Hox-A4
References
(Earliest) J:8339 Rubin MR, et al., A mouse homeo box gene is expressed in spermatocytes and embryos. Science. 1986 Aug 8;233(4764):663-7
(Latest) J:218555 Sheikh BN, et al., Excessive versus physiologically relevant levels of retinoic acid in embryonic stem cell differentiation. Stem Cells. 2014 Jun;32(6):1451-8
All references(104)
Other
accession IDs
MGD-MRK-10820, MGD-MRK-10877, MGI:2141624

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory