Hoxa2
Gene Detail

Symbol Name ID

Hoxa2 homeobox A2 MGI:96174

STS

D6Mit93

Synonyms

Hox-1.11

Feature Type

protein coding gene

Genetic Map

Chromosome 6

25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:52162351-52165413 bp, - strand From VEGA annotation of GRCm38   3063 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B2
Gene Tree: Hoxa2

Human homologs

Human Homolog		HOXA2, homeobox A2
NCBI Gene ID		3199
neXtProt AC		NX_O43364
Human Synonyms		HOX1K
Human Chr (Location)		7p15.2; chr7:27139973-27142394 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HOXA2

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Mutant homozygotes lack skeletal elements normally derived from the second branchial arch and show duplication of elements derived from the first branchial arch, such as ossification centers of the middle ear. Mutants die perinatally with cleft palate.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	anterior/posterior pattern specification, brain segmentation, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (89 records)
Data Summary: Results (454)    Tissues (250)    Images (89)
Theiler Stages: 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	389
In situ reporter (knock in)	8
Northern blot	5
RT-PCR	52

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) Genomic(8) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037358 (Evidence)
Ensembl Gene Model	ENSMUSG00000014704 (Evidence)
Entrez Gene	15399 (Evidence)
UniGene	131
DFCI	TC1585146
DoTS	DT.488537
NIA Mouse Gene Index	U027301
Consensus CDS Project	CCDS20139.1
International Mouse Knockout Project Status	Hoxa2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037358	VEGA Gene Model | MGI Sequence Detail	3063	C57BL/6J
transcript	OTTMUST00000045381	VEGA | MGI Sequence Detail	2423	Not Applicable
polypeptide	OTTMUSP00000020418	VEGA | MGI Sequence Detail	372	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008690	homeobox protein Hox-A2

References

(Earliest) J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
(Latest) J:193058 Miguez A, et al., Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning. J Neurosci. 2012 Nov 28;32(48):17172-85
All references(142)

Other accession IDs

MGD-MRK-10817, MGD-MRK-10875, MGI:2141392