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Hoxa2 Gene Detail
Summary
  • Symbol
    Hoxa2
  • Name
    homeobox A2
  • Synonyms
    Hox-1.11
  • Feature Type
    protein coding gene
  • IDs
    MGI:96174
    NCBI Gene: 15399
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA2
Location & Maps
more
  • Sequence Map
    Chr6:52162417-52164831 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2415 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    6 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    HOXA2, homeobox A2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HOXA2, homeobox A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX1K, MCOHI
  • Links
    NCBI Gene ID: 3199
    neXtProt AC: NX_O43364

  • Chr Location
    7p15.2; chr7:27100354-27102775 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HOXA2 associations

Human Disease Mouse Models
       Microtia, Hearing Impairment, and Cleft Palate   OMIM: 612290
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 11 alleles in 15 genetic backgrounds
    18 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Targeted
    16
  • Genomic Mutations
    1 involving Hoxa2
  • Incidental Mutations
Mutant homozygotes lack skeletal elements normally derived from the second branchial arch and show duplication of elements derived from the first branchial arch, such as ossification centers of the middle ear. Mutants die perinatally with cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037358 VEGA Gene Model | MGI Sequence Detail 2415 C57BL/6J ±  kb
transcript OTTMUST00000045381 VEGA | MGI Sequence Detail 1775 Not Applicable  
polypeptide OTTMUSP00000020418 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 38
    Genomic 8
    cDNA 23
    Primer pair 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10817, MGD-MRK-10875, MGI:2141392
References
more
  • Summaries
    All 159
    Developmental Gene Expression 108
    Gene Ontology 18
    Phenotypes 51
  • Earliest
    J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
  • Latest
    J:235740 Rosin JM, et al., A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex. Development. 2016 Jul 15;143(14):2582-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory