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Hoxa2 Gene Detail
Summary
  • Symbol
    Hoxa2
  • Name
    homeobox A2
  • Synonyms
    Hox-1.11
  • Feature Type
    protein coding gene
  • IDs
    MGI:96174
    NCBI Gene: 15399
  • Member of
    Hoxa cluster
  • Gene Overview
    MyGene.info: HOXA2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52162417-52164831 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    6 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96174
protein coding gene Chr6:52162417-52164831 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030739
protein coding gene Chr6:51397827-51400241 (-)
A/J MGP_AJ_G0030709
protein coding gene Chr6:48997935-49000349 (-)
AKR/J MGP_AKRJ_G0030635
protein coding gene Chr6:50703399-50705813 (-)
BALB/cJ MGP_BALBcJ_G0030720
protein coding gene Chr6:49357299-49359713 (-)
C3H/HeJ MGP_C3HHeJ_G0030434
protein coding gene Chr6:50712131-50714545 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031175
protein coding gene Chr6:52535391-52537805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028382
protein coding gene Chr6:46646026-46648416 (-)
CAST/EiJ MGP_CASTEiJ_G0029836
protein coding gene Chr6:50524198-50526614 (-)
CBA/J MGP_CBAJ_G0030407
protein coding gene Chr6:54731149-54733563 (-)
DBA/2J MGP_DBA2J_G0030557
protein coding gene Chr6:48920904-48923318 (-)
FVB/NJ MGP_FVBNJ_G0030509
protein coding gene Chr6:48530974-48533388 (-)
LP/J MGP_LPJ_G0030642
protein coding gene Chr6:51382602-51385016 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030543
protein coding gene Chr6:57367167-57369581 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031205
protein coding gene Chr6:50627939-50630353 (-)
PWK/PhJ MGP_PWKPhJ_G0029549
protein coding gene Chr6:48542643-48545058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029384
protein coding gene Chr6:49965839-49968253 (-)
WSB/EiJ MGP_WSBEiJ_G0029913
protein coding gene Chr6:50645158-50647572 (-)



Homology
more
  • Human Ortholog
    HOXA2, homeobox A2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HOXA2, homeobox A2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX1K, MCOHI
  • Links
    NCBI Gene ID: 3199
    neXtProt AC: NX_O43364
    UniProt: O43364

  • Chr Location
    7p15.2; chr7:27100354-27102775 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    79 phenotypes from 11 alleles in 15 genetic backgrounds
    19 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant homozygotes lack skeletal elements normally derived from the second branchial arch and show duplication of elements derived from the first branchial arch, such as ossification centers of the middle ear. Mutants die perinatally with cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15399 NCBI Gene Model | MGI Sequence Detail 2415 C57BL/6J ±  kb
    transcript NM_010451 RefSeq | MGI Sequence Detail 1775 Not Specified  
    polypeptide P31245 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 8
      cDNA 26
      Primer pair 8
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10817, MGD-MRK-10875, MGI:2141392
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 113
      Gene Ontology 20
      Phenotypes 56
    • Earliest
      J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
    • Latest
      J:264530 Zaffran S, et al., Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations. Genesis. 2018 Jun;56(6-7):e23221

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory