About   Help   FAQ
Hoxa2
Gene Detail
Symbol

Name
ID
Member of
Hoxa2
homeobox A2
MGI:96174
Hoxa cluster
STS
Synonyms
Hox-1.11
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:52162511-52164831 bp, - strand
From VEGA annotation of GRCm38

  2321 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4901  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXA2
Protein SuperFamily: homeotic protein Hox B2
Gene Tree: Hoxa2

Human
homologs
HOXA2, homeobox A2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3199
neXtProt AC: NX_O43364

Human Synonyms: HOX1K, MCOHI

Human Chr (Location): 7p15.2; chr7:27100354-27102775 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HOXA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Genomic Mutations involving Hoxa2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes lack skeletal elements normally derived from the second branchial arch and show duplication of elements derived from the first branchial arch, such as ossification centers of the middle ear. Mutants die perinatally with cleft palate.
 
Interactions
Hoxa2 interacts with 114 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (103 records)
Data Summary: Results (502)    Tissues (272)    Images (110)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
RNA in situ 393
In situ reporter (knock in) 8
Northern blot 5
Western blot 6
RT-PCR 58
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hoxa2 ; ZFIN hoxa2b    NEW 
Molecular
reagents
All nucleic(37) Genomic(8) cDNA(22) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037358 (Evidence)
Ensembl Gene Model ENSMUSG00000014704 (Evidence)
Entrez Gene 15399 (Evidence)
UniGene 131
DFCI TC1585146
DoTS DT.488537
NIA Mouse Gene Index U027301
Consensus CDS Project CCDS20139.1
International Mouse Phenotyping Consortium Status Hoxa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037358 VEGA Gene Model | MGI Sequence Detail 2321 C57BL/6J ±  kb
transcript OTTMUST00000045381 VEGA | MGI Sequence Detail 1681 Not Applicable 
polypeptide OTTMUSP00000020418 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008690 homeobox protein Hox-A2
References
(Earliest) J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
(Latest) J:222399 Kitazawa T, et al., Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015 Jun 15;402(2):162-74
All references(157)
Other
accession IDs
MGD-MRK-10817, MGD-MRK-10875, MGI:2141392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory