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Hoxa2
Gene Detail
 Symbol
Name
ID
Member of
Hoxa2
homeobox A2
MGI:96174
Hoxa cluster
STS D6Mit93
Synonyms Hox-1.11
Feature Type protein coding gene
Genetic Map
Chromosome 6
25.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:52162511-52164831 bp, - strand
From VEGA annotation of GRCm38

  2321 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4901  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox B2
Gene Tree: Hoxa2

Human
homologs
Human Homolog HOXA2, homeobox A2
NCBI Gene ID 3199
neXtProt AC  NX_O43364
Human Synonyms  HOX1K, MCOHI
Human Chr (Location)  7p15.2; chr7:27100354-27102775 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HOXA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes lack skeletal elements normally derived from the second branchial arch and show duplication of elements derived from the first branchial arch, such as ossification centers of the middle ear. Mutants die perinatally with cleft palate.
 
Interactions
Hoxa2 interacts with 113 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process anterior/posterior pattern specification, brain segmentation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (96 records)
Data Summary: Results (458)    Tissues (252)    Images (91)
Theiler Stages: 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 393
In situ reporter (knock in) 8
Northern blot 5
RT-PCR 52
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(8) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037358 (Evidence)
Ensembl Gene ModelENSMUSG00000014704 (Evidence)
Entrez Gene15399 (Evidence)
UniGene131
DFCITC1585146
DoTSDT.488537
NIA Mouse Gene IndexU027301
Consensus CDS ProjectCCDS20139.1
International Mouse Knockout Project StatusHoxa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037358 VEGA Gene Model | MGI Sequence Detail 2321 C57BL/6J ±  kb
transcript OTTMUST00000045381 VEGA | MGI Sequence Detail 1681 Not Applicable 
polypeptide OTTMUSP00000020418 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008690 homeobox protein Hox-A2
References (Earliest) J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
(Latest) J:208432 Schwarz D, et al., Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77
All references(151)
Other
accession IDs
MGD-MRK-10817, MGD-MRK-10875, MGI:2141392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory