About   Help   FAQ
Hmga1 Gene Detail
Summary
  • Symbol
    Hmga1
  • Name
    high mobility group AT-hook 1
  • Synonyms
    Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY
  • Feature Type
    protein coding gene
  • IDs
    MGI:96160
    NCBI Gene: 15361
  • Gene Overview
    MyGene.info: HMGA1
Location & Maps
more
  • Sequence Map
    Chr17:27556620-27563674 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7055 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.50 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    HMGA1, high mobility group AT-hook 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HMGA1, high mobility group AT-hook 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMGA1A, HMGIY, HMG-R
  • Links
    NCBI Gene ID: 3159
    neXtProt AC: NX_P17096

  • Chr Location
    6p21.31; chr6:34236800-34246231 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hmga1 mouse models; 1 with human HMGA1 associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Gene trapped
    31
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Hmga1
  • Incidental Mutations
Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028935 VEGA Gene Model | MGI Sequence Detail 7055 C57BL/6J ±  kb
transcript OTTMUST00000071708 VEGA | MGI Sequence Detail 1635 Not Applicable  
polypeptide OTTMUSP00000036805 VEGA | MGI Sequence Detail 107 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    46 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10796, MGI:2144347
References
more
  • Summaries
    All 85
    Developmental Gene Expression 17
    Diseases 1
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory