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Hmga1
Gene Detail
Symbol

Name
ID
Hmga1
high mobility group AT-hook 1
MGI:96160
Synonyms
Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:27556620-27563674 bp, + strand
From VEGA annotation of GRCm38

  7055 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128226  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: HMGA1
Protein SuperFamily: nonhistone chromosomal protein HMG-I
Gene Tree: Hmga1

Human
homologs
HMGA1, high mobility group AT-hook 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3159
neXtProt AC: NX_P17096

Human Synonyms: HMGA1A, HMGIY, HMG-R

Human Chr (Location): 6p21; chr6:34236800-34246231 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HMGA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(31) Radiation induced(1) Targeted(8)
Genomic Mutations involving Hmga1 (1)
Incidental mutations (data from CvDC )
 
Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
 
Human Diseases Modeled in Mice Using Hmga1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hmga1 interacts with 175 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process base-excision repair, DNA metabolic process, ...
Component focal adhesion, nucleus, ...
Function 5'-deoxyribose-5-phosphate lyase activity, DNA-(apurinic or apyrimidinic site) lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (448)    Tissues (134)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 399
Northern blot 41
RT-PCR 8
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hmga1a    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028935 (Evidence)
Ensembl Gene Model ENSMUSG00000046711 (Evidence)
Entrez Gene 15361 (Evidence)
Consensus CDS Project CCDS28564.1, CCDS50044.1
International Mouse Phenotyping Consortium Status Hmga1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028935 VEGA Gene Model | MGI Sequence Detail 7055 C57BL/6J ±  kb
transcript OTTMUST00000071713 VEGA | MGI Sequence Detail 1003 Not Applicable 
polypeptide OTTMUSP00000036810 VEGA | MGI Sequence Detail 107 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(28)
Polymorphisms
RFLP(2) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008628 high mobility group protein HMG-I/HMG-Y
References
(Earliest) J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
(Latest) J:211181 Federico A, et al., Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype. Biol Open. 2014;3(5):372-8
All references(80)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10796, MGI:2144347

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory