About   Help   FAQ
Hmga1
Gene Detail
 Symbol
Name
ID
Hmga1
high mobility group AT-hook 1
MGI:96160
Synonyms Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY
Feature Type protein coding gene
Genetic Map
Chromosome 17
14.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:27556620-27563674 bp, + strand
From VEGA annotation of GRCm38

  7055 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128226  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: nonhistone chromosomal protein HMG-I
Gene Tree: Hmga1

Human
homologs
Human Homolog HMGA1, high mobility group AT-hook 1
NCBI Gene ID 3159
neXtProt AC  NX_P17096
Human Synonyms  HMGA1A, HMGIY, HMG-R
Human Chr (Location)  6p21; chr6:34236800-34246231 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HMGA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(31) Radiation induced(1) Targeted(8)
Genomic Mutations involving Hmga1 (1)
 
Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
 
Human Diseases Modeled Using Mouse Hmga1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hmga1 interacts with 175 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process DNA catabolic process, endonucleolytic, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus, senescence-associated heterochromatin focus
Function 5'-deoxyribose-5-phosphate lyase activity, DNA-(apurinic or apyrimidinic site) lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (448)    Tissues (126)    Images (47)
Theiler Stages: 2, 3, 4, 5, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 399
Northern blot 41
RT-PCR 8
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000028935 (Evidence)
Ensembl Gene ModelENSMUSG00000046711 (Evidence)
Entrez Gene15361 (Evidence)
Consensus CDS ProjectCCDS28564.1, CCDS50044.1
International Mouse Knockout Project StatusHmga1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028935 VEGA Gene Model | MGI Sequence Detail 7055 C57BL/6J ±  kb
transcript OTTMUST00000071708 VEGA | MGI Sequence Detail 1635 Not Applicable 
polypeptide OTTMUSP00000036805 VEGA | MGI Sequence Detail 107 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(28)
Polymorphisms RFLP(2) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000008628 high mobility group protein HMG-I/HMG-Y
References (Earliest) J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
(Latest) J:210588 Martins VC, et al., Cell competition is a tumour suppressor mechanism in the thymus. Nature. 2014 May 22;509(7501):465-70
All references(75)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10796, MGI:2144347

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory