Hmga1
Gene Detail

Symbol Name ID

Hmga1 high mobility group AT-hook 1 MGI:96160

Synonyms

Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY

Feature Type

protein coding gene

Genetic Map

Chromosome 17

14.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:27556620-27563674 bp, + strand From VEGA annotation of GRCm38   7055 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: nonhistone chromosomal protein HMG-I
Gene Tree: Hmga1

Alleles and phenotypes

All alleles(38) : Targeted(7) Gene trapped(31)
 

Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.

 
Human Diseases Modeled Using Mouse Hmga1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	spermatogenesis
Component	nucleus
Function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (427)    Tissues (103)    Images (45)
Theiler Stages: 2, 3, 4, 5, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	371
Northern blot	41
RT-PCR	15

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028935 (Evidence)
Ensembl Gene Model	ENSMUSG00000046711 (Evidence)
Entrez Gene	15361 (Evidence)
Consensus CDS Project	CCDS28564.1, CCDS50044.1
International Mouse Knockout Project Status	Hmga1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028935	VEGA Gene Model | MGI Sequence Detail	7055	C57BL/6J
transcript	OTTMUST00000071708	VEGA | MGI Sequence Detail	1635	Not Applicable
polypeptide	OTTMUSP00000036805	VEGA | MGI Sequence Detail	107	Not Applicable

All sequences(80) RefSeq(28)

Polymorphisms

RFLP(2) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000008628	high mobility group protein HMG-I/HMG-Y

References

(Earliest) J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
(Latest) J:192701 Bloch M, et al., High-mobility group A1 protein: a new coregulator of peroxisome proliferator-activated receptor-gamma-mediated transrepression in the vasculature. Circ Res. 2012 Feb 3;110(3):394-405
All references(71)

Other accession IDs

MGD-MRK-10796, MGI:2144347