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Hmgb2
Gene Detail
Symbol

Name
ID
Hmgb2
high mobility group box 2
MGI:96157
Synonyms
Hmg2, HMG-2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:57511843-57515999 bp, + strand
From NCBI annotation of GRCm38

  4157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37582  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: HMGB2
Gene Tree: Hmgb2

Human
homologs
HMGB2, high mobility group box 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3148
neXtProt AC: NX_P26583

Human Synonyms: HMG2

Human Chr (Location): 4q31; chr4:173331376-173334444 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Male mice homozygous for disruptions in this gene display reduced fertility. Female fertility is normal.
 
Interactions
Hmgb2 interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process cell chemotaxis, chromatin remodeling, ...
Component cell, chromosome, ...
Function chemoattractant activity, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (449)    Tissues (178)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 447
RT-PCR 1
cDNA source data(23)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase hmgb2 ; ZFIN hmgb2a, hmgb2b    NEW 
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000054717 (Evidence)
Entrez Gene 97165 (Evidence)
DFCI TC1573261, TC1657066, TC1713731
DoTS DT.101160132, DT.101400005, DT.110832594, DT.537187, DT.94349997
NIA Mouse Gene Index U050792, U082436, U123995, U172450, U363397, U374780, U374992
Consensus CDS Project CCDS40343.1
International Mouse Phenotyping Consortium Status Hmgb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 97165 NCBI Gene Model | MGI Sequence Detail 4157 C57BL/6J ±  kb
transcript NM_008252 RefSeq | MGI Sequence Detail 2692 C57BL/6 
polypeptide P30681 UniProt | EBI | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR017967 HMG box A DNA-binding domain, conserved site
Protein Ontology PR:000008631 high mobility group protein B2
Graphical View of Protein Domain Structure
References
(Earliest) J:2642 Stolzenburg F, et al., Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2) [published erratum appears in Nucleic Acids Res 1992 Oct 11;20(19):5262]. Nucleic Acids Res. 1992 Sep 25;20(18):4927
(Latest) J:221515 Lee S, et al., A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat Chem Biol. 2014 Dec;10(12):1055-60
All references(60)
Other
accession IDs
MGD-MRK-10793, MGI:2140686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory