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Hmgb2
Gene Detail
Symbol

Name
ID
Hmgb2
high mobility group box 2
MGI:96157
Synonyms
Hmg2, HMG-2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
29.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:57511843-57515999 bp, + strand
From NCBI annotation of GRCm38

  4157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37582  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hmgb2

Human
homologs
Human Homolog HMGB2, high mobility group box 2
NCBI Gene ID 3148
neXtProt AC  NX_P26583
Human Synonyms  HMG2
Human Chr (Location)  4q31; chr4:173331376-173334444 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
 
Male mice homozygous for disruptions in this gene display reduced fertility. Female fertility is normal.
 
Interactions
Hmgb2 interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process base-excision repair, DNA ligation, cell chemotaxis, ...
Component chromosome, condensed chromosome, ...
Function chemoattractant activity, damaged DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (450)    Tissues (179)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 448
RT-PCR 1
cDNA source data(23)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000054717 (Evidence)
Entrez Gene97165 (Evidence)
DFCITC1573261, TC1657066, TC1713731
DoTSDT.101160132, DT.101400005, DT.110832594, DT.537187, DT.94349997
NIA Mouse Gene IndexU050792, U082436, U123995, U172450, U363397, U374780, U374992
Consensus CDS ProjectCCDS40343.1
International Mouse Knockout Project StatusHmgb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 97165 NCBI Gene Model | MGI Sequence Detail 4157 C57BL/6J ±  kb
transcript NM_008252 RefSeq | MGI Sequence Detail 2692 C57BL/6 
polypeptide P30681 UniProt | EBI | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR017967 HMG box A DNA-binding domain, conserved site
Protein Ontology PR:000008631 high mobility group protein B2
Graphical View of Protein Domain Structure
References
(Earliest) J:2642 Stolzenburg F, et al., Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2) [published erratum appears in Nucleic Acids Res 1992 Oct 11;20(19):5262]. Nucleic Acids Res. 1992 Sep 25;20(18):4927
(Latest) J:209829 Abraham AB, et al., Aberrant neural stem cell proliferation and increased adult neurogenesis in mice lacking chromatin protein HMGB2. PLoS One. 2013;8(12):e84838
All references(61)
Other
accession IDs
MGD-MRK-10793, MGI:2140686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory