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Hmgb2 Gene Detail
Summary
  • Symbol
    Hmgb2
  • Name
    high mobility group box 2
  • Synonyms
    Hmg2, HMG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96157
    NCBI Gene: 97165
  • Gene Overview
    MyGene.info: HMGB2
Location & Maps
more
  • Sequence Map
    Chr8:57511843-57515999 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4157 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.90 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    HMGB2, high mobility group box 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HMGB2, high mobility group box 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HMG2
  • Links
    NCBI Gene ID: 3148
    neXtProt AC: NX_P26583

  • Chr Location
    4q31; chr4:173331376-173334444 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Hmgb2
Male mice homozygous for disruptions in this gene display reduced fertility. Female fertility is normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 97165 NCBI Gene Model | MGI Sequence Detail 4157 C57BL/6J ±  kb
transcript NM_008252 RefSeq | MGI Sequence Detail 2692 C57BL/6  
polypeptide P30681 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    21 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008631 high mobility group protein B2
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR031075 High mobility group protein HMGB2
    IPR017967 HMG box A DNA-binding domain, conserved site
Molecular
Reagents
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  • All nucleic 27
    cDNA 24
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-10793, MGI:2140686
References
more
  • Summaries
    All 58
    Developmental Gene Expression 19
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:2642 Stolzenburg F, et al., Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2) [published erratum appears in Nucleic Acids Res 1992 Oct 11;20(19):5262]. Nucleic Acids Res. 1992 Sep 25;20(18):4927
  • Latest
    J:221515 Lee S, et al., A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat Chem Biol. 2014 Dec;10(12):1055-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory