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Asmt Gene Detail
Summary
  • Symbol
    Asmt
  • Name
    acetylserotonin O-methyltransferase
  • Synonyms
    Hiomt
  • Feature Type
    protein coding gene
  • IDs
    MGI:96090
    NCBI Gene: 107626
Location & Maps
more
  • Sequence Map
    ChrX:170672644-170678054 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, Syntenic
  • Mapping Data
    1 experiment
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
  • All Mutations and Alleles
    2
  • Gene trapped
    2
Pineal melatonin synthesis requires enzymes encoded by Asmt and Aanat. C57BL/6, BALB/c, AKR/J, NZB/Bl, IS/Cam, and CAST/Ei carry the a allele of Asmt and lack melatonin. SK/Cam, SF/Cam, PERU, and FDS carry the b allele and have normal melatonin levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 107626 NCBI Gene Model | MGI Sequence Detail 5411 C57BL/6J ±  kb
transcript NM_001199212 RefSeq | MGI Sequence Detail 1273 C3H/He  
polypeptide D3KU67 UniProt | EBI | MGI Sequence Detail 387 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR031725 Acetylserotonin O-methyltransferase, dimerisation domain
    IPR016461 O-methyltransferase COMT-type
    IPR001077 O-methyltransferase, family 2
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR011991 Winged helix-turn-helix DNA-binding domain
Other
Accession IDs
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MGD-MRK-10719
References
more
  • Summaries
    All 13
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
  • Latest
    J:159317 Kasahara T, et al., Genetic variation of melatonin productivity in laboratory mice under domestication. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6412-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory