About   Help   FAQ
Asmt
Gene Detail
 Symbol
Name
ID
Asmt
acetylserotonin O-methyltransferase
MGI:96090
Synonyms Hiomt
Feature Type protein coding gene
Genetic Map
Chromosome X
Syntenic

Mapping data(1)
Sequence Map
ChrX:170672644-170678054 bp, + strand
From NCBI annotation of GRCm38

  5411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: O-mtase
Gene Tree: Asmt
Alleles
and
phenotypes
All alleles(2) : Gene trapped(2)
 
Pineal melatonin synthesis requires enzymes encoded by Asmt and Aanat. C57BL/6, BALB/c, AKR/J, NZB/Bl, IS/Cam, and CAST/Ei carry the a allele of Asmt and lack melatonin. SK/Cam, SF/Cam, PERU, and FDS carry the b allele and have normal melatonin levels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process melatonin biosynthetic process, methylation, ...
Component cellular_component
Function acetylserotonin O-methyltransferase activity, methyltransferase activity, ...
External Resources: FuncBase
Expression
External Resources: GEO   ArrayExpress
Other database
links
Ensembl Gene ModelENSMUSG00000093806 (Evidence)
Entrez Gene107626 (Evidence)
UniGene486144
EC2.1.1.4
International Mouse Knockout Project StatusAsmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107626 NCBI Gene Model | MGI Sequence Detail 5411 C57BL/6J ±  kb
transcript NM_001199212 RefSeq | MGI Sequence Detail 1273 C3H/He 
polypeptide D3KU66 UniProt | EBI | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(12) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016461 Caffeate O-methyltransferase (COMT) family
InterPro IPR001077 O-methyltransferase, family 2
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000004374 acetylserotonin O-methyltransferase
Graphical View of Protein Domain Structure
References (Earliest) J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
(Latest) J:159317 Kasahara T, et al., Genetic variation of melatonin productivity in laboratory mice under domestication. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6412-7
All references(14)
Other
accession IDs
MGD-MRK-10719

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory