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Hhex
Gene Detail
Symbol

Name
ID
Hhex
hematopoietically expressed homeobox
MGI:96086
Synonyms
Hex, Hex1, Hhex-rs2, Prhx
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.28 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:37434810-37440731 bp, + strand
From VEGA annotation of GRCm38

  5922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31110  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HHEX
Gene Tree: Hhex

Human
homologs
HHEX, hematopoietically expressed homeobox
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3087
neXtProt AC: NX_Q03014

Human Synonyms: HEX, HMPH, HOX11L-PEN, PRH, PRHX

Human Chr (Location): 10q23.33; chr10:92689924-92695651 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
 
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis and cardiac development. Mice homozygous for another knock-out allele exhibit embryonic lethality, fetal lethality and abnormal nervous system development.
 
Interactions
Hhex interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process anterior/posterior pattern specification, B cell differentiation, ...
Component cytoplasm, nucleus, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (137 records)
Data Summary: Results (349)    Tissues (223)    Images (107)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 316
In situ reporter (knock in) 4
Northern blot 7
Western blot 1
RT-PCR 16
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HHEX ; Xenbase hhex ; ZFIN hhex    NEW 
Molecular
reagents
All nucleic(44) Genomic(5) cDNA(28) Primer pair(5) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021162 (Evidence)
Ensembl Gene Model ENSMUSG00000024986 (Evidence)
Entrez Gene 15242 (Evidence)
UniGene 33896
DFCI TC1582902, TC1595953
DoTS DT.60118175, DT.94261172
NIA Mouse Gene Index U019413
Consensus CDS Project CCDS29778.1
International Mouse Phenotyping Consortium Status Hhex
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021162 VEGA Gene Model | MGI Sequence Detail 5922 C57BL/6J ±  kb
transcript OTTMUST00000050138 VEGA | MGI Sequence Detail 1802 Not Applicable 
polypeptide OTTMUSP00000023363 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008540 hematopoietically-expressed homeobox protein HHEX
References
(Earliest) J:4210 Bedford FK, et al., HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 1993 Mar 11;21(5):1245-9
(Latest) J:221385 Jackson JT, et al., A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis. Blood. 2015 Jan 29;125(5):803-14
All references(194)
Other
accession IDs
MGD-MRK-10715, MGI:1201390, MGI:1277985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory