About   Help   FAQ
Hhex
Gene Detail
 Symbol
Name
ID
Hhex
hematopoietically expressed homeobox
MGI:96086
Synonyms Hex, Hex1, Hhex-rs2, Prhx
Feature Type protein coding gene
Genetic Map
Chromosome 19
32.28 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:37434810-37440731 bp, + strand
From VEGA annotation of GRCm38

  5922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31110  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hhex

Human
homologs
Human Homolog HHEX, hematopoietically expressed homeobox
NCBI Gene ID 3087
neXtProt AC  NX_Q03014
Human Synonyms  HEX, HMPH, HOX11L-PEN, PRH, PRHX
Human Chr (Location)  10q23.33; chr10:92689924-92695651 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(9)
 
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis and cardiac development. Mice homozygous for another knock-out allele exhibit embryonic lethality, fetal lethality and abnormal nervous system development.
 
Interactions
Hhex interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process anterior/posterior pattern specification, B cell differentiation, ...
Component cytoplasm, nucleus, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (133 records)
Data Summary: Results (345)    Tissues (223)    Images (93)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 312
In situ reporter (knock in) 4
Northern blot 7
Western blot 1
RT-PCR 16
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(5) cDNA(27) Primer pair(5) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021162 (Evidence)
Ensembl Gene ModelENSMUSG00000024986 (Evidence)
Entrez Gene15242 (Evidence)
UniGene33896
DFCITC1582902, TC1595953
DoTSDT.60118175, DT.94261172
NIA Mouse Gene IndexU019413
Consensus CDS ProjectCCDS29778.1
International Mouse Knockout Project StatusHhex
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021162 VEGA Gene Model | MGI Sequence Detail 5922 C57BL/6J ±  kb
transcript OTTMUST00000050138 VEGA | MGI Sequence Detail 1802 Not Applicable 
polypeptide OTTMUSP00000023363 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008540 hematopoietically-expressed homeobox protein HHEX
References (Earliest) J:4210 Bedford FK, et al., HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 1993 Mar 11;21(5):1245-9
(Latest) J:209573 Zhang J, et al., The diabetes gene Hhex maintains delta-cell differentiation and islet function. Genes Dev. 2014 Apr 15;28(8):829-34
All references(189)
Other
accession IDs
MGD-MRK-10715, MGI:1201390, MGI:1277985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory