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Hdc
Gene Detail
Symbol

Name
ID
Hdc
histidine decarboxylase
MGI:96062
Synonyms
Hdc-a, Hdc-c, Hdc-e, Hdc-s, L-histidine decarboxylase
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.76 cM, cytoband E5-G
Detailed Genetic Map ± 1 cM


Mapping data(33)
Sequence Map
Chr2:126593667-126619299 bp, - strand
From VEGA annotation of GRCm38

  25633 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histidine decarboxylase
Gene Tree: Hdc

Human
homologs
Human Homolog HDC, histidine decarboxylase
NCBI Gene ID 3067
neXtProt AC  NX_P19113
Human Chr (Location)  15q21.2; chr15:50241947-50265965 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HDC
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal mast cells, altered anxiety-related and nociceptive behavior, altered cognitive function, increased weight gain, visceral adiposity, increased amount of brown adipose tissue, impaired glucose tolerance, hyperinsulinemia, and hyperleptinemia.
 
Interactions
Hdc interacts with 81 markers (Mir15a, Mir15b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process carboxylic acid metabolic process, catecholamine biosynthetic process, ...
Component cytosol, dendrite, ...
Function amino acid binding, carboxy-lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (324)    Tissues (214)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 317
RT-PCR 7
cDNA source data(54)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(1) cDNA(58) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015753 (Evidence)
Ensembl Gene ModelENSMUSG00000027360 (Evidence)
Entrez Gene15186 (Evidence)
UniGene18603
DFCITC1576172
DoTSDT.91365800, DT.94242525
NIA Mouse Gene IndexU023303
EC4.1.1.22
Consensus CDS ProjectCCDS16684.1
International Mouse Knockout Project StatusHdc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015753 VEGA Gene Model | MGI Sequence Detail 25633 C57BL/6J ±  kb
transcript OTTMUST00000037409 VEGA | MGI Sequence Detail 2392 Not Applicable 
polypeptide OTTMUSP00000016762 VEGA | MGI Sequence Detail 662 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(8) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010977 Aromatic-L-amino-acid decarboxylase
InterPro IPR021115 Pyridoxal-phosphate binding site
InterPro IPR002129 Pyridoxal phosphate-dependent decarboxylase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000008489 histidine decarboxylase
References
(Earliest) J:13778 Mortimer A, et al., Hdc - kidney histidine decarboxylase. Mouse News Lett. 1978;59:30
(Latest) J:212229 Provensi G, et al., Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11527-32
All references(156)
Other
accession IDs
MGD-MRK-10682, MGD-MRK-10683, MGD-MRK-10684, MGD-MRK-10685, MGD-MRK-10686, MGI:2139302, MGI:96063, MGI:96064, MGI:96065, MGI:96066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory