About   Help   FAQ
Hck
Gene Detail
 Symbol
Name
ID
Hck
hemopoietic cell kinase
MGI:96052
Synonyms Bmk, Hck-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
75.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr2:153108468-153151441 bp, + strand
From VEGA annotation of GRCm38

  42974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Hck

Human
homologs
Human Homolog HCK, HCK proto-oncogene, Src family tyrosine kinase
NCBI Gene ID 3055
neXtProt AC  NX_P08631
Human Synonyms  JTK9, p59Hck, p61Hck
Human Chr (Location)  20q11-q12; chr20:32052188-32101856 (+)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Macrophages from mice homozygous for a targeted null mutation exhibit impaired phagocytosis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process defense response to Gram-positive bacterium, exocytosis, ...
Component actin filament, caveola, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (75)    Tissues (14)    Images (24)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 73
RT-PCR 2
cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) Genomic(2) cDNA(32) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015777 (Evidence)
Ensembl Gene ModelENSMUSG00000003283 (Evidence)
Entrez Gene15162 (Evidence)
UniGene715
DFCITC1576965, TC1721292
DoTSDT.101302592, DT.94305133
NIA Mouse Gene IndexU002661
EC2.7.10.2
Consensus CDS ProjectCCDS38284.1, CCDS50756.1
International Mouse Knockout Project StatusHck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015777 VEGA Gene Model | MGI Sequence Detail 42974 C57BL/6J ±  kb
transcript OTTMUST00000089454 VEGA | MGI Sequence Detail 2092 Not Applicable 
polypeptide OTTMUSP00000048885 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(2)
Polymorphisms RFLP(6) : SNPs within 2kb(556 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000008473 tyrosine-protein kinase HCK
References (Earliest) J:8946 Holtzman DA, et al., Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8325-9
(Latest) J:201086 Verollet C, et al., Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J. 2013 Sep;27(9):3608-18
All references(106)
Other
accession IDs
MGD-MRK-10666, MGD-MRK-10667, MGD-MRK-1590, MGI:2139076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory