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Serpind1
Gene Detail
 Symbol
Name
ID
Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
MGI:96051
Synonyms Hcf2, HCII, HC II, heparin cofactor II
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr16:17331371-17343575 bp, + strand
From VEGA annotation of GRCm38

  12205 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36018  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: serpin
Gene Tree: Serpind1

Human
homologs
Human Homolog SERPIND1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1
NCBI Gene ID 3053
neXtProt AC  NX_P05546
Human Synonyms  D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10
Human Chr (Location)  22q11.21; chr22:20774095-20787720 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SERPIND1
Alleles
and
phenotypes
All alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular space, extracellular vesicular exosome
Function heparin binding, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (19)    Tissues (1)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 19
cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(49) Genomic(8) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030882 (Evidence)
Ensembl Gene ModelENSMUSG00000022766 (Evidence)
Entrez Gene15160 (Evidence)
UniGene6609
DFCITC1580111
DoTSDT.110715561, DT.110715674, DT.60118461
NIA Mouse Gene IndexU016870
Consensus CDS ProjectCCDS28000.1
International Mouse Knockout Project StatusSerpind1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030882 VEGA Gene Model | MGI Sequence Detail 12205 C57BL/6J ±  kb
transcript OTTMUST00000076423 VEGA | MGI Sequence Detail 2191 Not Applicable 
polypeptide OTTMUSP00000040228 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(121 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014701 heparin cofactor 2
References (Earliest) J:17526 Zhang GS, et al., Murine heparin cofactor II: purification, cDNA sequence, expression, and gene structure [published erratum appears in Biochemistry 1994 Jun 21;33(24):7744]. Biochemistry. 1994 Mar 29;33(12):3632-42
(Latest) J:193573 Charles JF, et al., The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov;51(5):902-12
All references(47)
Other
accession IDs
MGD-MRK-10665, MGI:2146372, MGI:2146402

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory