Serpind1
Gene Detail

Symbol Name ID

Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 MGI:96051

Synonyms

Hcf2, HCII, HC II, heparin cofactor II

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr16:17331371-17343575 bp, + strand From VEGA annotation of GRCm38   12205 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36018  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpind1

Human homologs

Human Homolog		SERPIND1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1
NCBI Gene ID		3053
neXtProt AC		NX_P05546
Human Synonyms		D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10
Human Chr (Location)		22q11.21; chr22:21128383-21142008 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SERPIND1

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	blood coagulation, hemostasis, ...
Function	heparin binding, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (19)    Tissues (1)    Images (19)
Theiler Stages: 23

Assay Type	Results
RNA in situ	19

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(8) cDNA(41)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030882 (Evidence)
Ensembl Gene Model	ENSMUSG00000022766 (Evidence)
Entrez Gene	15160 (Evidence)
UniGene	6609
DFCI	TC1580111
DoTS	DT.110715561, DT.110715674, DT.60118461
NIA Mouse Gene Index	U016870
Consensus CDS Project	CCDS28000.1
International Mouse Knockout Project Status	Serpind1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030882	VEGA Gene Model | MGI Sequence Detail	12205	C57BL/6J
transcript	OTTMUST00000076424	VEGA | MGI Sequence Detail	2051	Not Applicable
polypeptide	OTTMUSP00000042278	VEGA | MGI Sequence Detail	478	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(113 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR000295	Proteinase inhibitor I4, leuserpin 2
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014701	heparin cofactor 2

References

(Earliest) J:17526 Zhang GS, et al., Murine heparin cofactor II: purification, cDNA sequence, expression, and gene structure [published erratum appears in Biochemistry 1994 Jun 21;33(24):7744]. Biochemistry. 1994 Mar 29;33(12):3632-42
(Latest) J:193573 Charles JF, et al., The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov;51(5):902-12
All references(45)

Other accession IDs

MGD-MRK-10665, MGI:2146372, MGI:2146402