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Hc Gene Detail
Summary
  • Symbol
    Hc
  • Name
    hemolytic complement
  • Synonyms
    C5, C5a, He, Hfib2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96031
    NCBI Gene: 15139
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34873343-34951450 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 23.22 cM, cytoband cen-C1
  • Mapping Data
    72 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96031
 protein coding gene Chr2:34873341-34958518 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025647
 protein coding gene Chr2:33596255-33678815 (-)
A/J MGP_AJ_G0025624
 protein coding gene Chr2:32173812-32258165 (-)
AKR/J MGP_AKRJ_G0025594
 protein coding gene Chr2:33308803-33393875 (-)
BALB/cJ MGP_BALBcJ_G0025621
 protein coding gene Chr2:32282866-32364934 (-)
C3H/HeJ MGP_C3HHeJ_G0025381
 protein coding gene Chr2:33203574-33286741 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026065
 protein coding gene Chr2:34573162-34694662 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023474
 protein coding gene Chr2:30863172-30940553 (-)
CAST/EiJ MGP_CASTEiJ_G0024843
 protein coding gene Chr2:33186600-33270602 (-)
CBA/J MGP_CBAJ_G0025359
 protein coding gene Chr2:35904169-35990666 (-)
DBA/2J MGP_DBA2J_G0025492
 protein coding gene Chr2:31941726-32021495 (-)
FVB/NJ MGP_FVBNJ_G0025454
 protein coding gene Chr2:31843813-31921216 (-)
LP/J MGP_LPJ_G0025578
 protein coding gene Chr2:33524461-33607961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025485
 protein coding gene Chr2:35429016-35512609 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026123
 protein coding gene Chr2:33195081-33273077 (-)
PWK/PhJ MGP_PWKPhJ_G0024591
 protein coding gene Chr2:31854593-31933792 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024391
 protein coding gene Chr2:33362101-33444047 (-)
WSB/EiJ MGP_WSBEiJ_G0024912
 protein coding gene Chr2:33374685-33458337 (-)



Homology
more
  • Human Ortholog
    C5, complement C5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C5, complement C5
  • Synonyms
    C5a, C5b, C5D, CPAMD4, ECLZB
  • Links
    NCBI Gene ID: 727
    neXtProt AC: NX_P01031
    UniProt: P01031

  • Chr Location
    9q33.2; chr9:120952335-121075174 (-)  GRCh38.p7
  • Alliance of Genome Resources
    Hc stringent orthology
    1 human;1 mouse;1 zebrafish
  • HCOP
    vertebrate homology predictions: C5
  • Gene Tree
    Hc
Human Diseases
more
  • Diseases
    6 with human C5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Macrophage from mice homozygous for disruptions of this gene do not secrete complement C5.

The 2 bp deletion found in A/J and AKR/J strains is associated with susceptibility to allergen-induced bronchial hyperresponsiveness and is a candidate for QTL Abhr2.

Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    55
  • cDNA Data
    36
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026874 Ensembl Gene Model | MGI Sequence Detail 78108 C57BL/6J ±  kb
    transcript ENSMUST00000028233 Ensembl | MGI Sequence Detail 5445 Not Applicable  
    polypeptide ENSMUSP00000028233 Ensembl | MGI Sequence Detail 1680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 10
      cDNA 36
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10645, MGD-MRK-10689, MGD-MRK-1703, MGI:2181187
    References
    more
    • Summaries
      All 279
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 128
    • Earliest
      J:12959 HERZENBERG LA, et al., A gene locus concerned with hemolytic complement in Mus musculus. Genetics. 1963 May;48:711-5
    • Latest
      J:316687 Walbaum S, et al., Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms. J Biol Chem. 2021 Jan-Jun;296:100256
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/03/2022
    MGI 6.21     		The Jackson Laboratory