Hc
Gene Detail

Symbol

Name
ID

Hc
hemolytic complement
MGI:96031

Synonyms

C5, C5a, He

Feature Type

protein coding gene

Genetic Map

Chromosome 2
23.22 cM, cytoband cen-C1
Detailed Genetic Map ± 1 cM


Mapping data(71)

Sequence Map

Chr2:34983331-35061438 bp, - strand From VEGA annotation of GRCm38   78108 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20412  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Hc

Human
homologs

Human Homolog		C5, complement component 5
NCBI Gene ID		727
neXtProt AC		NX_P01031
Human Synonyms		C5a, C5b, C5D, CPAMD4, ECLZB
Human Chr (Location)		9q33-q34; chr9:120952335-121050276 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human C5

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Macrophage from mice homozygous for disruptions of this gene do not secrete complement C5.

The 2 bp deletion found in A/J and AKR/J strains is associated with susceptibility to allergen-induced bronchial hyperresponsiveness and is a candidate for QTL Abhr2.

 

Interactions

Hc interacts with 101 markers (Mir17, Mir19a, Mir19b-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (17 annotations)

Process	complement activation, alternative pathway, complement activation, classical pathway, ...
Component	extracellular region, extracellular space, ...
Function	endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (41)    Tissues (34)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	41

cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(48) Genomic(10) cDNA(35) Primer pair(2) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000012274 (Evidence)
Ensembl Gene Model	ENSMUSG00000026874 (Evidence)
Entrez Gene	15139 (Evidence)
UniGene	2168
DFCI	TC1584853
DoTS	DT.491887
NIA Mouse Gene Index	U022536
PDB	4P3A, 4P3B
Consensus CDS Project	CCDS15957.1
International Mouse Knockout Project Status	Hc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012274	VEGA Gene Model | MGI Sequence Detail	78108	C57BL/6J
transcript	OTTMUST00000029212	VEGA | MGI Sequence Detail	5445	Not Applicable
polypeptide	OTTMUSP00000013195	VEGA | MGI Sequence Detail	1680	Not Applicable

All sequences(38) RefSeq(5) UniProt(5)

Polymorphisms

All PCR and RFLP(14) : PCR(1) RFLP(13) SNPs within 2kb(381 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR018081	Anaphylatoxin
InterPro	IPR000020	Anaphylatoxin/fibulin
InterPro	IPR001840	Complement C3a/C4a/C5a anaphylatoxin
InterPro	IPR001134	Netrin domain
InterPro	IPR018933	Netrin module, non-TIMP type
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000004904	complement C5

References

(Earliest) J:12959 HERZENBERG LA, et al., A gene locus concerned with hemolytic complement in Mus musculus. Genetics. 1963 May;48:711-5
(Latest) J:206648 Baudino L, et al., C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8
All references(209)

Other
accession IDs

MGD-MRK-10645, MGD-MRK-10689, MGD-MRK-1703