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Hc Gene Detail
Summary
  • Symbol
    Hc
  • Name
    hemolytic complement
  • Synonyms
    C5, C5a, He
  • Feature Type
    protein coding gene
  • IDs
    MGI:96031
    NCBI Gene: 15139
  • Gene Overview
    MyGene.info: C5
Location & Maps
more
  • Sequence Map
    Chr2:34983331-35061438 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      78108 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 23.22 cM, cytoband cen-C1
  • Mapping Data
    71 experiments
Homology
more
  • Human Ortholog
    C5, complement C5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C5, complement C5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C5a, C5b, C5D, CPAMD4, ECLZB
  • Links
    NCBI Gene ID: 727
    neXtProt AC: NX_P01031

  • Chr Location
    9q33-q34; chr9:120952335-121074925 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    2 with human C5 associations

Human Disease Mouse Models
       Complement Component 5 Deficiency; C5D   OMIM: 609536
Eculizumab, Poor Response to   OMIM: 615749
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    4
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Macrophage from mice homozygous for disruptions of this gene do not secrete complement C5.

The 2 bp deletion found in A/J and AKR/J strains is associated with susceptibility to allergen-induced bronchial hyperresponsiveness and is a candidate for QTL Abhr2.

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    66
  • Tissues
    48
  • cDNA Data
    35
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012274 VEGA Gene Model | MGI Sequence Detail 78108 C57BL/6J ±  kb
transcript OTTMUST00000029212 VEGA | MGI Sequence Detail 5445 Not Applicable  
polypeptide OTTMUSP00000013195 VEGA | MGI Sequence Detail 1680 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    379 from dbSNP Build 142
  • PCR
    1
  • RFLP
    13
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    Genomic 10
    cDNA 35
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10645, MGD-MRK-10689, MGD-MRK-1703
References
more
  • Summaries
    All 206
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 93
  • Earliest
    J:12959 HERZENBERG LA, et al., A gene locus concerned with hemolytic complement in Mus musculus. Genetics. 1963 May;48:711-5
  • Latest
    J:227541 Jackson HM, et al., DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. PLoS One. 2015;10(5):e0125897
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory