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Hc
Gene Detail
 Symbol
Name
ID
Hc
hemolytic complement
MGI:96031
Synonyms C5, C5a, He
Feature Type protein coding gene
Genetic Map
Chromosome 2
23.22 cM, cytoband cen-C1
Detailed Genetic Map ± 1 cM


Mapping data(71)
Sequence Map
Chr2:34983331-35061438 bp, - strand
From VEGA annotation of GRCm38

  78108 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20412  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Hc

Human
homologs
Human Homolog C5, complement component 5
NCBI Gene ID 727
neXtProt AC  NX_P01031
Human Synonyms  C5a, C5b, C5D, CPAMD4, ECLZB
Human Chr (Location)  9q33-q34; chr9:120952335-121050276 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human C5
Alleles
and
phenotypes
All alleles(5) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Macrophage from mice homozygous for disruptions of this gene do not secrete complement C5.

The 2 bp deletion found in A/J and AKR/J strains is associated with susceptibility to allergen-induced bronchial hyperresponsiveness and is a candidate for QTL Abhr2.

 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process complement activation, alternative pathway, complement activation, classical pathway, ...
Component extracellular region, extracellular space, ...
Function endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (41)    Tissues (30)   
Theiler Stages: 16, 18, 20, 21, 23, 25, 28
Assay TypeResults
RT-PCR 41
cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(48) Genomic(10) cDNA(35) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012274 (Evidence)
Ensembl Gene ModelENSMUSG00000026874 (Evidence)
Entrez Gene15139 (Evidence)
UniGene2168
DFCITC1584853
DoTSDT.491887
NIA Mouse Gene IndexU022536
Consensus CDS ProjectCCDS15957.1
International Mouse Knockout Project StatusHc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012274 VEGA Gene Model | MGI Sequence Detail 78108 C57BL/6J ±  kb
transcript OTTMUST00000029212 VEGA | MGI Sequence Detail 5445 Not Applicable 
polypeptide OTTMUSP00000013195 VEGA | MGI Sequence Detail 1680 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(5) UniProt(3)
Polymorphisms All PCR and RFLP(14) : PCR(1) RFLP(13) SNPs within 2kb(381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR018081 Anaphylatoxin
InterPro IPR000020 Anaphylatoxin/fibulin
InterPro IPR001840 Complement C3a/C4a/C5a anaphylatoxin
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000004904 complement C5
References (Earliest) J:12959 HERZENBERG LA, et al., A gene locus concerned with hemolytic complement in Mus musculus. Genetics. 1963 May;48:711-5
(Latest) J:206648 Baudino L, et al., C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8
All references(208)
Other
accession IDs
MGD-MRK-10645, MGD-MRK-10689, MGD-MRK-1703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory