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Hc Gene Detail
Summary
  • Symbol
    Hc
  • Name
    hemolytic complement
  • Synonyms
    C5, C5a, He, Hfib2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96031
    NCBI Gene: 15139
  • Gene Overview
    MyGene.info: C5
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:34983331-35061438 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      78108 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 23.22 cM, cytoband cen-C1
  • Mapping Data
    72 experiments
Homology
more
  • Human Ortholog
    C5, complement C5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C5, complement C5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C5a, C5b, C5D, CPAMD4, ECLZB
  • Links
    NCBI Gene ID: 727
    neXtProt AC: NX_P01031
    UniProt: P01031

  • Chr Location
    9q33.2; chr9:120952335-121075174 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human C5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Macrophage from mice homozygous for disruptions of this gene do not secrete complement C5.

The 2 bp deletion found in A/J and AKR/J strains is associated with susceptibility to allergen-induced bronchial hyperresponsiveness and is a candidate for QTL Abhr2.

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    66
  • Tissues
    48
  • cDNA Data
    35
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012274 VEGA Gene Model | MGI Sequence Detail 78108 C57BL/6J ±  kb
    transcript OTTMUST00000029212 VEGA | MGI Sequence Detail 5445 Not Applicable  
    polypeptide OTTMUSP00000013195 VEGA | MGI Sequence Detail 1680 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      379 from dbSNP Build 142
    • PCR
      1
    • RFLP
      13
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 10
      cDNA 35
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10645, MGD-MRK-10689, MGD-MRK-1703, MGI:2181187
    References
    more
    • Summaries
      All 235
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 99
    • Earliest
      J:12959 HERZENBERG LA, et al., A gene locus concerned with hemolytic complement in Mus musculus. Genetics. 1963 May;48:711-5
    • Latest
      J:261609 Syed SN, et al., C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. Eur J Immunol. 2018 Apr;48(4):696-704
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory