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Hbb-y Gene Detail
Summary
  • Symbol
    Hbb-y
  • Name
    hemoglobin Y, beta-like embryonic chain
  • Synonyms
    epsilon Y globin, Ey, Hby
  • Feature Type
    protein coding gene
  • IDs
    MGI:96027
    NCBI Gene: 15135
  • Member of
    Hbb cluster
Location & Maps
more
  • Sequence Map
    Chr7:103851745-103853240 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1496 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HBG2, hemoglobin subunit gamma 2
  • Vertebrate Orthologs
    14
  • Human Ortholog
    HBG2, hemoglobin subunit gamma 2
    Orthology source: HomoloGene
  • Synonyms
    HBG-T1, TNCY
  • Links
    NCBI Gene ID: 3048
    neXtProt AC: NX_P69892

  • Chr Location
    11p15.5; chr11:5253191-5254781 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HBG2 associations

Human Disease Mouse Models
       Cyanosis, Transient Neonatal; TNCY   OMIM: 613977
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from multigenic genotypes
    61 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    3 involving Hbb-y
  • Incidental Mutations
Mice with disruptions in this gene are grossly normal and viable through adulthood.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019058 VEGA Gene Model | MGI Sequence Detail 1496 C57BL/6J ±  kb
transcript OTTMUST00000045676 VEGA | MGI Sequence Detail 661 Not Applicable  
polypeptide OTTMUSP00000020553 VEGA | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    99 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 633
    Genomic 24
    cDNA 596
    Primer pair 11
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10639
References
more
  • Summaries
    All 112
    Developmental Gene Expression 72
    Diseases 7
    Gene Ontology 5
    Phenotypes 61
  • Earliest
    J:5065 Gilman JG, et al., Fetal hemoglobin variants in mice. Science. 1968 May 24;160(830):885-6
  • Latest
    J:224837 Dutchak PA, et al., Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory