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Hbb-y Gene Detail
Summary
  • Symbol
    Hbb-y
  • Name
    hemoglobin Y, beta-like embryonic chain
  • Synonyms
    epsilon Y globin, Ey, Hby
  • Feature Type
    protein coding gene
  • IDs
    MGI:96027
    NCBI Gene: 15135
  • Member of
    Hbb cluster
  • Gene Overview
    MyGene.info: HBE1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:103500961-103502414 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96027
protein coding gene Chr7:103500956-103502423 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032686
protein coding gene Chr7:107067646-107069145 (-)
A/J MGP_AJ_G0032659
protein coding gene Chr7:104281045-104282544 (-)
AKR/J MGP_AKRJ_G0032592
protein coding gene Chr7:106802033-106803532 (-)
BALB/cJ MGP_BALBcJ_G0032669
protein coding gene Chr7:104011527-104013026 (-)
C3H/HeJ MGP_C3HHeJ_G0032380
protein coding gene Chr7:107143986-107145485 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033165
protein coding gene Chr7:111054723-111056218 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030161
protein coding gene Chr7:106374170-106375695 (-)
CAST/EiJ MGP_CASTEiJ_G0031711
protein coding gene Chr7:98697686-98699182 (-)
CBA/J MGP_CBAJ_G0032348
protein coding gene Chr7:114983116-114984615 (-)
DBA/2J MGP_DBA2J_G0032502
protein coding gene Chr7:102598509-102600008 (-)
FVB/NJ MGP_FVBNJ_G0032455
protein coding gene Chr7:102321474-102322973 (-)
LP/J MGP_LPJ_G0032595
protein coding gene Chr7:108385976-108387475 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032491
protein coding gene Chr7:116308872-116310367 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033192
protein coding gene Chr7:105987846-105989341 (-)
PWK/PhJ MGP_PWKPhJ_G0031425
protein coding gene Chr7:95583488-95584987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031269
protein coding gene Chr7:93261704-93263199 (-)
WSB/EiJ MGP_WSBEiJ_G0031825
protein coding gene Chr7:106717369-106718868 (-)



Homology
more
  • Human Ortholog
    HBE1, hemoglobin subunit epsilon 1
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBE1, hemoglobin subunit epsilon 1
  • Synonyms
    HBE
  • Links
    NCBI Gene ID: 3046
    neXtProt AC: NX_P02100
    UniProt: P02100

  • Chr Location
    11p15.4; chr11:5268350-5270143 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from multigenic genotypes
    89 phenotype references
Mice with disruptions in this gene are grossly normal and viable through adulthood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15135 NCBI Gene Model | MGI Sequence Detail 1454 C57BL/6J ±  kb
transcript NM_008221 RefSeq | MGI Sequence Detail 619 C57BL/6  
polypeptide P02104 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 638
    Genomic 24
    cDNA 598
    Primer pair 14
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10639
References
more
  • Summaries
    All 214
    Developmental Gene Expression 87
    Diseases 1
    Gene Ontology 5
    Phenotypes 89
  • Earliest
    J:5065 Gilman JG, et al., Fetal hemoglobin variants in mice. Science. 1968 May 24;160(830):885-6
  • Latest
    J:315129 Buehler PW, et al., Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory